FR2394521A1 - Nouveaux polypeptides, produits intermediaires pour leur preparation et composition et procedes utilisant ces polypeptides - Google Patents

Nouveaux polypeptides, produits intermediaires pour leur preparation et composition et procedes utilisant ces polypeptides

Info

Publication number
FR2394521A1
FR2394521A1 FR7817761A FR7817761A FR2394521A1 FR 2394521 A1 FR2394521 A1 FR 2394521A1 FR 7817761 A FR7817761 A FR 7817761A FR 7817761 A FR7817761 A FR 7817761A FR 2394521 A1 FR2394521 A1 FR 2394521A1
Authority
FR
France
Prior art keywords
polypeptides
amino
preparation
chiral
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7817761A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of FR2394521A1 publication Critical patent/FR2394521A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/675—Beta-endorphins
    • C07K14/6755—Beta-endorphins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne de nouveaux polypeptides et un procédé pour leur préparation. Ces polypeptides répondent à la formule : H-Tyr-X-Z-Y dans laquelle X est un résidu chiral d'un D-amino-acide choisi parmi la D'alanine, la D-leucine, la D'isoleucine, la D-valine, la D-phénylalanine, la D-tyrosine, le D-tryptophane, la D-sérine, la D-histidine, la D-proline, la D-thréonine, la D-méthionine, l'acide D-glutamique, la D-glutamine, l'acide D-aspartique, la D-asparagine, la D-lysine et la D-arginine; Y est choisi parmi les groupes hydroxy, amino, (alcoyl inférieur)amino, di(alcoyl inférieur)amino et alcoxy inférieur; Z est un segment d'une chaîne de bêta-lipotropine de mammifère, commençant au fragment chiral 63 et contenant de 1 à 29 fragments chiraux; et leurs sels pharmaceutiquement acceptables, avec la limitation que Z n'est pas le fragment 63-65 de bêta-lipotropine. Ils sont utiles en tant que médicaments.
FR7817761A 1977-06-16 1978-06-14 Nouveaux polypeptides, produits intermediaires pour leur preparation et composition et procedes utilisant ces polypeptides Pending FR2394521A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80712777A 1977-06-16 1977-06-16

Publications (1)

Publication Number Publication Date
FR2394521A1 true FR2394521A1 (fr) 1979-01-12

Family

ID=25195641

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7817761A Pending FR2394521A1 (fr) 1977-06-16 1978-06-14 Nouveaux polypeptides, produits intermediaires pour leur preparation et composition et procedes utilisant ces polypeptides

Country Status (11)

Country Link
JP (1) JPS5470216A (fr)
AU (1) AU3710778A (fr)
BE (1) BE868218A (fr)
DE (1) DE2826533A1 (fr)
FR (1) FR2394521A1 (fr)
GB (1) GB2000151B (fr)
IL (1) IL54920A0 (fr)
IT (1) IT1099555B (fr)
MX (1) MX5770E (fr)
NL (1) NL7806540A (fr)
ZA (1) ZA783287B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2418787A1 (fr) * 1978-03-02 1979-09-28 Hoffmann La Roche Nouveaux analogues des b-endorphines et leur application en tant que medicaments

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2960258D1 (en) * 1978-03-02 1981-05-07 Akzo Nv Psychopharmacological peptides, process for their preparation and their pharmaceutical formulations
AU530062B2 (en) * 1979-02-21 1983-06-30 Akzo N.V. Psycho-pharmacological peptides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038222A (en) * 1976-03-17 1977-07-26 Hoffman-La Roche Inc. Untriakontapeptide with opiate activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038222A (en) * 1976-03-17 1977-07-26 Hoffman-La Roche Inc. Untriakontapeptide with opiate activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/77 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2418787A1 (fr) * 1978-03-02 1979-09-28 Hoffmann La Roche Nouveaux analogues des b-endorphines et leur application en tant que medicaments

Also Published As

Publication number Publication date
IT1099555B (it) 1985-09-18
JPS5470216A (en) 1979-06-05
BE868218A (fr) 1978-10-16
IT7824664A0 (it) 1978-06-16
NL7806540A (nl) 1978-12-19
MX5770E (es) 1984-07-06
ZA783287B (en) 1980-01-30
IL54920A0 (en) 1978-08-31
DE2826533A1 (de) 1979-01-11
GB2000151B (en) 1982-03-17
AU3710778A (en) 1979-12-20
GB2000151A (en) 1979-01-04

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