FR2392967A1 - NEW ACETAMIDOXIME DERIVATIVES USEFUL PARTICULARLY IN THERAPEUTICS - Google Patents
NEW ACETAMIDOXIME DERIVATIVES USEFUL PARTICULARLY IN THERAPEUTICSInfo
- Publication number
- FR2392967A1 FR2392967A1 FR7810109A FR7810109A FR2392967A1 FR 2392967 A1 FR2392967 A1 FR 2392967A1 FR 7810109 A FR7810109 A FR 7810109A FR 7810109 A FR7810109 A FR 7810109A FR 2392967 A1 FR2392967 A1 FR 2392967A1
- Authority
- FR
- France
- Prior art keywords
- group
- alkyl
- acetamidoxime
- new
- therapeutics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- AEXITZJSLGALNH-UHFFFAOYSA-N n'-hydroxyethanimidamide Chemical class CC(N)=NO AEXITZJSLGALNH-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- -1 3-hydantoinyl Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000006168 tricyclic group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/58—Amidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne en tant que produits industriels nouveaux des dérivés acétamidoximes de formule générale : CR1 R2 R3 -C(= NH)NHOH dans laquelle R 2 est H, alkyle en C1 -C6 , pyridyle; R3 est H, alkyle en C1 -C6 ; et R1 est alkyle en C1 -C6 carbamoyle N,N-disubstitué, 3-hydantoïnyle, benzhydrylcarboxamido, arylsulfinyle, benzimidazolyle, un groupe tricyclique ou un groupe Z4 -A Øou Z4 est un groupe phényle, un groupe alpha -naphtyle, un groupe beta -naphtyle ( chaque noyau phényle de ces groupes pouvant être notamment substitué par un ou plusieurs groupes alkyles en C 1 -C4 , alkoxy en C1 -C4 , méthylènedioxy, halogène, CF3 , NH2, NO2 ) ou un groupe adamantyle; et A représente CONH-, -CON(alkyle en C1 -C4 )-, -CON(cycloalkyle enThe present invention relates as new industrial products to acetamidoxime derivatives of general formula: CR1 R2 R3 -C (= NH) NHOH in which R 2 is H, C1 -C6 alkyl, pyridyl; R3 is H, C1 -C6 alkyl; and R1 is C1 -C6 alkylcarbamoyl N, N-disubstituted, 3-hydantoinyl, benzhydrylcarboxamido, arylsulfinyl, benzimidazolyl, a tricyclic group or a group Z4 -A Øor Z4 is a phenyl group, an alpha -naphthyl group, a beta group -naphthyl (each phenyl ring of these groups possibly being substituted by one or more C 1 -C4 alkyl, C1 -C4 alkoxy, methylenedioxy, halogen, CF3, NH2, NO2) or an adamantyl group; and A represents CONH-, -CON (C1 -C4 alkyl) -, -CON (cycloalkyl in
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1670377A GB1602110A (en) | 1977-04-21 | 1977-04-21 | Acetamidoxime derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2392967A1 true FR2392967A1 (en) | 1978-12-29 |
FR2392967B1 FR2392967B1 (en) | 1981-12-11 |
Family
ID=10082146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7810109A Granted FR2392967A1 (en) | 1977-04-21 | 1978-04-05 | NEW ACETAMIDOXIME DERIVATIVES USEFUL PARTICULARLY IN THERAPEUTICS |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE866163A (en) |
FR (1) | FR2392967A1 (en) |
GB (1) | GB1602110A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2506767A1 (en) * | 1981-05-26 | 1982-12-03 | Synthelabo | HETEROCYCLIC DERIVATIVES OF AMIDOXIMES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005117847A2 (en) * | 2004-06-02 | 2005-12-15 | Combinatorx, Incorporated | Methods and compounds for the treatment of neoplasms |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR8293M (en) * | 1967-06-01 | 1970-11-16 |
-
1977
- 1977-04-21 GB GB1670377A patent/GB1602110A/en not_active Expired
-
1978
- 1978-04-05 FR FR7810109A patent/FR2392967A1/en active Granted
- 1978-04-20 BE BE2056890A patent/BE866163A/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR8293M (en) * | 1967-06-01 | 1970-11-16 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2506767A1 (en) * | 1981-05-26 | 1982-12-03 | Synthelabo | HETEROCYCLIC DERIVATIVES OF AMIDOXIMES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
EP0067094A1 (en) * | 1981-05-26 | 1982-12-15 | Synthelabo | Heterocyclic derivatives of amidoximes, their preparation and therapeutic uses |
Also Published As
Publication number | Publication date |
---|---|
FR2392967B1 (en) | 1981-12-11 |
BE866163A (en) | 1978-10-20 |
GB1602110A (en) | 1981-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |