FR2392967A1 - NEW ACETAMIDOXIME DERIVATIVES USEFUL PARTICULARLY IN THERAPEUTICS - Google Patents

NEW ACETAMIDOXIME DERIVATIVES USEFUL PARTICULARLY IN THERAPEUTICS

Info

Publication number
FR2392967A1
FR2392967A1 FR7810109A FR7810109A FR2392967A1 FR 2392967 A1 FR2392967 A1 FR 2392967A1 FR 7810109 A FR7810109 A FR 7810109A FR 7810109 A FR7810109 A FR 7810109A FR 2392967 A1 FR2392967 A1 FR 2392967A1
Authority
FR
France
Prior art keywords
group
alkyl
acetamidoxime
new
therapeutics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7810109A
Other languages
French (fr)
Other versions
FR2392967B1 (en
Inventor
Louis Lafon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of FR2392967A1 publication Critical patent/FR2392967A1/en
Application granted granted Critical
Publication of FR2392967B1 publication Critical patent/FR2392967B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/58—Amidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne en tant que produits industriels nouveaux des dérivés acétamidoximes de formule générale : CR1 R2 R3 -C(= NH)NHOH dans laquelle R 2 est H, alkyle en C1 -C6 , pyridyle; R3 est H, alkyle en C1 -C6 ; et R1 est alkyle en C1 -C6 carbamoyle N,N-disubstitué, 3-hydantoïnyle, benzhydrylcarboxamido, arylsulfinyle, benzimidazolyle, un groupe tricyclique ou un groupe Z4 -A Øou Z4 est un groupe phényle, un groupe alpha -naphtyle, un groupe beta -naphtyle ( chaque noyau phényle de ces groupes pouvant être notamment substitué par un ou plusieurs groupes alkyles en C 1 -C4 , alkoxy en C1 -C4 , méthylènedioxy, halogène, CF3 , NH2, NO2 ) ou un groupe adamantyle; et A représente CONH-, -CON(alkyle en C1 -C4 )-, -CON(cycloalkyle enThe present invention relates as new industrial products to acetamidoxime derivatives of general formula: CR1 R2 R3 -C (= NH) NHOH in which R 2 is H, C1 -C6 alkyl, pyridyl; R3 is H, C1 -C6 alkyl; and R1 is C1 -C6 alkylcarbamoyl N, N-disubstituted, 3-hydantoinyl, benzhydrylcarboxamido, arylsulfinyl, benzimidazolyl, a tricyclic group or a group Z4 -A Øor Z4 is a phenyl group, an alpha -naphthyl group, a beta group -naphthyl (each phenyl ring of these groups possibly being substituted by one or more C 1 -C4 alkyl, C1 -C4 alkoxy, methylenedioxy, halogen, CF3, NH2, NO2) or an adamantyl group; and A represents CONH-, -CON (C1 -C4 alkyl) -, -CON (cycloalkyl in

FR7810109A 1977-04-21 1978-04-05 NEW ACETAMIDOXIME DERIVATIVES USEFUL PARTICULARLY IN THERAPEUTICS Granted FR2392967A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1670377A GB1602110A (en) 1977-04-21 1977-04-21 Acetamidoxime derivatives

Publications (2)

Publication Number Publication Date
FR2392967A1 true FR2392967A1 (en) 1978-12-29
FR2392967B1 FR2392967B1 (en) 1981-12-11

Family

ID=10082146

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7810109A Granted FR2392967A1 (en) 1977-04-21 1978-04-05 NEW ACETAMIDOXIME DERIVATIVES USEFUL PARTICULARLY IN THERAPEUTICS

Country Status (3)

Country Link
BE (1) BE866163A (en)
FR (1) FR2392967A1 (en)
GB (1) GB1602110A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2506767A1 (en) * 1981-05-26 1982-12-03 Synthelabo HETEROCYCLIC DERIVATIVES OF AMIDOXIMES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117847A2 (en) * 2004-06-02 2005-12-15 Combinatorx, Incorporated Methods and compounds for the treatment of neoplasms

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR8293M (en) * 1967-06-01 1970-11-16

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR8293M (en) * 1967-06-01 1970-11-16

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2506767A1 (en) * 1981-05-26 1982-12-03 Synthelabo HETEROCYCLIC DERIVATIVES OF AMIDOXIMES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP0067094A1 (en) * 1981-05-26 1982-12-15 Synthelabo Heterocyclic derivatives of amidoximes, their preparation and therapeutic uses

Also Published As

Publication number Publication date
FR2392967B1 (en) 1981-12-11
BE866163A (en) 1978-10-20
GB1602110A (en) 1981-11-04

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