FR2391212A1 - 4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate - Google Patents

4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate

Info

Publication number
FR2391212A1
FR2391212A1 FR7715072A FR7715072A FR2391212A1 FR 2391212 A1 FR2391212 A1 FR 2391212A1 FR 7715072 A FR7715072 A FR 7715072A FR 7715072 A FR7715072 A FR 7715072A FR 2391212 A1 FR2391212 A1 FR 2391212A1
Authority
FR
France
Prior art keywords
pyridyl
cpds
alkyl
thiazolidine
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7715072A
Other languages
French (fr)
Other versions
FR2391212B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7715072A priority Critical patent/FR2391212A1/en
Priority to OA56480BISA priority patent/OA05950A/en
Priority to NL7804977A priority patent/NL7804977A/en
Priority to NL7804971A priority patent/NL7804971A/en
Priority to GR56236A priority patent/GR63587B/en
Priority to ZA00782800A priority patent/ZA782800B/en
Priority to JP5816478A priority patent/JPS5416475A/en
Priority to JP5816578A priority patent/JPS5416476A/en
Priority to NZ187289A priority patent/NZ187289A/en
Priority to ES469896A priority patent/ES469896A1/en
Priority to IE982/78A priority patent/IE46828B1/en
Priority to IT23470/78A priority patent/IT1096218B/en
Priority to GB19927/78A priority patent/GB1575274A/en
Priority to LU79662A priority patent/LU79662A1/en
Priority to IL54735A priority patent/IL54735A0/en
Priority to SE7805588A priority patent/SE7805588L/en
Priority to GB19926/78A priority patent/GB1586917A/en
Priority to SE7805589A priority patent/SE7805589L/en
Priority to ZA00782799A priority patent/ZA782799B/en
Priority to LU79663A priority patent/LU79663A1/en
Priority to IE983/78A priority patent/IE46829B1/en
Priority to DK214278A priority patent/DK214278A/en
Priority to BE187745A priority patent/BE867129A/en
Priority to IL54736A priority patent/IL54736A/en
Priority to PT197868047A priority patent/PT68047B/en
Priority to AU36137/78A priority patent/AU3613778A/en
Priority to ES469883A priority patent/ES469883A1/en
Priority to US05/906,599 priority patent/US4164579A/en
Priority to IT23473/78A priority patent/IT1096219B/en
Priority to BE187744A priority patent/BE867128A/en
Priority to HU78RO982A priority patent/HU175030B/en
Priority to NO78781712A priority patent/NO781712L/en
Priority to PT68048A priority patent/PT68048B/en
Priority to NZ187290A priority patent/NZ187290A/en
Priority to DK214078A priority patent/DK214078A/en
Priority to AU36138/78A priority patent/AU514150B2/en
Priority to AT356778A priority patent/ATA356778A/en
Priority to CA303,554A priority patent/CA1093078A/en
Priority to DE19782821566 priority patent/DE2821566A1/en
Priority to FI781567A priority patent/FI781567A/en
Priority to AT0356878A priority patent/AT363473B/en
Priority to CA303,572A priority patent/CA1092120A/en
Priority to SU782615706A priority patent/SU852171A3/en
Priority to DE19782821555 priority patent/DE2821555A1/en
Priority to SU782616146A priority patent/SU799659A3/en
Publication of FR2391212A1 publication Critical patent/FR2391212A1/en
Application granted granted Critical
Publication of FR2391212B1 publication Critical patent/FR2391212B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

4-Hydroxy-3-pyridyl-thiazolidine-2-thiones of formula (I) are new: In the formulae, R1 is opt. branched, 1-4C alkyl in position 4,5, or 6 and R2 is H or opt. branched 1-4C alkyl. The cpds. may be administered orally, rectally or parenterally e.g. orally to adults in daily doses of 50-1000 mg. Typical cpds. are (I) where R1 = 6-methyl. Cpds. where R2 = H or 1-4C primary or secondary alkyl have predominantly structure (A) whilst R2 = t-butyl has predominantly structure (B).
FR7715072A 1977-05-17 1977-05-17 4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate Granted FR2391212A1 (en)

Priority Applications (45)

Application Number Priority Date Filing Date Title
FR7715072A FR2391212A1 (en) 1977-05-17 1977-05-17 4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate
OA56480BISA OA05950A (en) 1977-05-17 1978-04-27 New derivatives of 4-hydroxy thiazolidinethione-2 and their preparation.
NL7804977A NL7804977A (en) 1977-05-17 1978-05-09 NEW 4-HYDROXYTHIAZOLIDINETHION-2 DERIVATIVES, ITS PREPARATIONS AND PREPARATIONS CONTAINING THE NEW DERIVATIVES.
NL7804971A NL7804971A (en) 1977-05-17 1978-05-09 NEW 4-HYDROXYTHIAZOLIDINETHION-2 DERIVATIVES, ITS PREPARATIONS AND PREPARATIONS CONTAINING THE NEW DERIVATIVES.
GR56236A GR63587B (en) 1977-05-17 1978-05-15 Method for preparation of new derivations of hydroxy-4-thiazolidinethione-2
ZA00782800A ZA782800B (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thiones
JP5816478A JPS5416475A (en) 1977-05-17 1978-05-16 44hydroxythiazolidinee22 thione derivative and production thereof
JP5816578A JPS5416476A (en) 1977-05-17 1978-05-16 44hydroxythiazolidinee22 thione
NZ187289A NZ187289A (en) 1977-05-17 1978-05-16 4-hydroxy-3-(pyrid-2-yl)-thiazolidine-2-thione derivatives and pharmaceutical compositions
ES469896A ES469896A1 (en) 1977-05-17 1978-05-16 Hydroxythiazolidine-2-thiones
IE982/78A IE46828B1 (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thiones
IT23470/78A IT1096218B (en) 1977-05-17 1978-05-16 DERIVATIVES OF HYDROXY-4 THIAZOLIDINTION-2, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
GB19927/78A GB1575274A (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thiones
LU79662A LU79662A1 (en) 1977-05-17 1978-05-16 NEW DERIVATIVES OF HYDROXY-4 THIAZOLIDINE THIONE-2, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
IL54735A IL54735A0 (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thione derivatives, a process for their preparation and pharmaceutical compositions containing them
SE7805588A SE7805588L (en) 1977-05-17 1978-05-16 PROCEDURE FOR THE PREPARATION OF NEW 4-HYDROXITIAZOLIDIN-2-THION DERIVATIVES
GB19926/78A GB1586917A (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thione derivatives
SE7805589A SE7805589L (en) 1977-05-17 1978-05-16 PROCEDURE FOR THE PREPARATION OF NEW 4-HYDROXITIAZOLIDIN-2-THION DERIVATIVES
ZA00782799A ZA782799B (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thione derivatives
LU79663A LU79663A1 (en) 1977-05-17 1978-05-16 NEW DERIVATIVES OF HYDROXY-4 THIAZOLIDINETHIONE-2, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
IE983/78A IE46829B1 (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thione derivatives
DK214278A DK214278A (en) 1977-05-17 1978-05-16 METHOD OF PREPARING 4-HYDROXYTHIAZOLIDIN-2-THION DERIVATIVES
BE187745A BE867129A (en) 1977-05-17 1978-05-16 NEW DERIVATIVES OF HYDROXY-4 THIAZOLIDINETHIONE-2, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
IL54736A IL54736A (en) 1977-05-17 1978-05-16 3-(substituted pyridinyl)-4-hydroxythiazolidine-2-thione derivatives, a process for their preparation and pharmaceutical compositions containing them
PT197868047A PT68047B (en) 1977-05-17 1978-05-16 NOVEL DERIVATIVES OF HYDROXY-4 THIAZOLIDINETHIONE-2 PREPARATION THEREOF AND THE COMPOSITIONS CONTAINING THEM
AU36137/78A AU3613778A (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thione derivatives
ES469883A ES469883A1 (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thione derivatives
US05/906,599 US4164579A (en) 1977-05-17 1978-05-16 Hydroxythiazolidine-2-thiones
IT23473/78A IT1096219B (en) 1977-05-17 1978-05-16 DERIVATIVES OF HYDROXY-4 THIAZOLIDINTION-2, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
BE187744A BE867128A (en) 1977-05-17 1978-05-16 NEW DERIVATIVES OF HYDROXY-4 THIAZOLIDINETHIONE-2, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
HU78RO982A HU175030B (en) 1977-05-17 1978-05-16 Process for preparing new 3-pyridyl-4-hydroxy-2-thiazolidine-thione derivatives
NO78781712A NO781712L (en) 1977-05-17 1978-05-16 PROCEDURE FOR PREPARING NEW DERIVATIVES OF 4-HYDROXYTIAZOLIDIN-2-THION
PT68048A PT68048B (en) 1977-05-17 1978-05-16 NOVEL HYDROXY-THIAZOLIDINE THIONE-2 DERIVATIVES AND THE COMPOSITIONS CONTAINING THEM
NZ187290A NZ187290A (en) 1977-05-17 1978-05-16 4-hydroxy-3-(pyrid-2-yl)-thiazolidine-2-thione derivatives and pharmaceutical or veterinary compositions
DK214078A DK214078A (en) 1977-05-17 1978-05-16 PROCEDURE FOR THE PREPARATION OF 4-HYDROXYTHIAZOLIDIN-2-THION DERIVATIVES
AU36138/78A AU514150B2 (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2 thiones
AT356778A ATA356778A (en) 1977-05-17 1978-05-17 METHOD FOR PRODUCING NEW 4-HYDROXY-THIAZOLIDIN-2-THION DERIVATIVES AND THEIR SALTS
CA303,554A CA1093078A (en) 1977-05-17 1978-05-17 No translation available
DE19782821566 DE2821566A1 (en) 1977-05-17 1978-05-17 4-HYDROXY-THIAZOLIDINE-2-THIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS OF THESE
FI781567A FI781567A (en) 1977-05-17 1978-05-17 NYA 4-HYDROXY-THIAZOLIDINE-2-THIONER FOR FAR OVERFLOWING
AT0356878A AT363473B (en) 1977-05-17 1978-05-17 METHOD FOR PRODUCING NEW 4-HYDROXY-THIAZOLIDIN-2-THION DERIVATIVES
CA303,572A CA1092120A (en) 1977-05-17 1978-05-17 Pas de traduction disponible
SU782615706A SU852171A3 (en) 1977-05-17 1978-05-17 Method of preparing derivatives of 4-oxythiazolidinthioketene-2 and their salts
DE19782821555 DE2821555A1 (en) 1977-05-17 1978-05-17 4-HYDROXI-THIAZOLIDINE-2-THIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS OF THESE
SU782616146A SU799659A3 (en) 1977-05-17 1978-05-17 Method of preparing 5-(4'-dimethylaminobenzoyl)-2-indancarboxylic acid, its salts or esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7715072A FR2391212A1 (en) 1977-05-17 1977-05-17 4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate

Publications (2)

Publication Number Publication Date
FR2391212A1 true FR2391212A1 (en) 1978-12-15
FR2391212B1 FR2391212B1 (en) 1980-05-09

Family

ID=9190912

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7715072A Granted FR2391212A1 (en) 1977-05-17 1977-05-17 4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate

Country Status (7)

Country Link
JP (1) JPS5416475A (en)
AT (1) AT363473B (en)
DK (1) DK214278A (en)
FR (1) FR2391212A1 (en)
HU (1) HU175030B (en)
SU (1) SU799659A3 (en)
ZA (2) ZA782800B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2441613A1 (en) * 1978-11-16 1980-06-13 Rhone Poulenc Ind NEW DITHIOCARBAMATES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2441613A1 (en) * 1978-11-16 1980-06-13 Rhone Poulenc Ind NEW DITHIOCARBAMATES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM

Also Published As

Publication number Publication date
ZA782800B (en) 1979-05-30
SU799659A3 (en) 1981-01-23
ZA782799B (en) 1979-02-28
JPS5416475A (en) 1979-02-07
FR2391212B1 (en) 1980-05-09
ATA356878A (en) 1981-01-15
HU175030B (en) 1980-04-28
DK214278A (en) 1978-11-18
AT363473B (en) 1981-08-10

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