FR2385714A1 - NEW ANTIBIOTIC NAMED C-15003, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT - Google Patents
NEW ANTIBIOTIC NAMED C-15003, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCTInfo
- Publication number
- FR2385714A1 FR2385714A1 FR7730339A FR7730339A FR2385714A1 FR 2385714 A1 FR2385714 A1 FR 2385714A1 FR 7730339 A FR7730339 A FR 7730339A FR 7730339 A FR7730339 A FR 7730339A FR 2385714 A1 FR2385714 A1 FR 2385714A1
- Authority
- FR
- France
- Prior art keywords
- application
- preparation process
- medicinal product
- new antibiotic
- antibiotic named
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The antibiotic C-15003 is a valuable fungicidal agent, antiprotozoal agent and cytostatic. It corresponds to the formula: in which R represents the radical -COCH(CH3)2, -COCH2CH2CH3 or -COCH2CH(CH3)2. The preparation is effected by cultivating a microorganism of the genus Nocardia. The radical R can be eliminated by reductive hydrolysis, thus giving rise to Maytansinol.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52037166A JPS6034556B2 (en) | 1977-03-31 | 1977-03-31 | Antibiotic C-15003 |
US81144977A | 1977-06-29 | 1977-06-29 | |
US05/811,448 US4162940A (en) | 1977-03-31 | 1977-06-29 | Method for producing Antibiotic C-15003 by culturing nocardia |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2385714A1 true FR2385714A1 (en) | 1978-10-27 |
FR2385714B1 FR2385714B1 (en) | 1982-05-14 |
Family
ID=27289347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7730339A Granted FR2385714A1 (en) | 1977-03-31 | 1977-10-07 | NEW ANTIBIOTIC NAMED C-15003, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT |
Country Status (2)
Country | Link |
---|---|
CH (1) | CH637137A5 (en) |
FR (1) | FR2385714A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2409307A1 (en) * | 1977-11-18 | 1979-06-15 | Takeda Chemical Industries Ltd | PROCESS FOR THE PRODUCTION OF ANTIBIOTIC C-15003 P-3 BY CULTURE OF A MICRO-ORGANISM |
FR2409306A1 (en) * | 1977-11-18 | 1979-06-15 | Takeda Chemical Industries Ltd | PROCESS FOR THE PRODUCTION OF THE ANTIBIOTIC C-15003 P-4 BY CULTURE OF A MICRO-ORGANISM OF THE GENUS NOCARDIA |
EP0011302A1 (en) * | 1978-11-20 | 1980-05-28 | Takeda Chemical Industries, Ltd. | Maytansinoids, their production and use |
EP0019934A1 (en) * | 1979-06-05 | 1980-12-10 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PND and process for their preparation |
-
1977
- 1977-10-07 FR FR7730339A patent/FR2385714A1/en active Granted
-
1978
- 1978-01-01 CH CH1260577A patent/CH637137A5/en not_active IP Right Cessation
Non-Patent Citations (2)
Title |
---|
EXBK/75 * |
EXBK/77 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2409307A1 (en) * | 1977-11-18 | 1979-06-15 | Takeda Chemical Industries Ltd | PROCESS FOR THE PRODUCTION OF ANTIBIOTIC C-15003 P-3 BY CULTURE OF A MICRO-ORGANISM |
FR2409306A1 (en) * | 1977-11-18 | 1979-06-15 | Takeda Chemical Industries Ltd | PROCESS FOR THE PRODUCTION OF THE ANTIBIOTIC C-15003 P-4 BY CULTURE OF A MICRO-ORGANISM OF THE GENUS NOCARDIA |
EP0011302A1 (en) * | 1978-11-20 | 1980-05-28 | Takeda Chemical Industries, Ltd. | Maytansinoids, their production and use |
EP0019934A1 (en) * | 1979-06-05 | 1980-12-10 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PND and process for their preparation |
Also Published As
Publication number | Publication date |
---|---|
CH637137A5 (en) | 1983-07-15 |
FR2385714B1 (en) | 1982-05-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |