FR2378094A2 - Biological reagent for diagnosis of specific illnesses - having an oxidised gluco-protein antibody on an insoluble support - Google Patents

Biological reagent for diagnosis of specific illnesses - having an oxidised gluco-protein antibody on an insoluble support

Info

Publication number
FR2378094A2
FR2378094A2 FR7701889A FR7701889A FR2378094A2 FR 2378094 A2 FR2378094 A2 FR 2378094A2 FR 7701889 A FR7701889 A FR 7701889A FR 7701889 A FR7701889 A FR 7701889A FR 2378094 A2 FR2378094 A2 FR 2378094A2
Authority
FR
France
Prior art keywords
opt
antibody
diagnosis
support
insoluble support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7701889A
Other languages
French (fr)
Other versions
FR2378094B2 (en
Inventor
Docteur Gerard Quash
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to FR7701889A priority Critical patent/FR2378094A2/en
Publication of FR2378094A2 publication Critical patent/FR2378094A2/en
Application granted granted Critical
Publication of FR2378094B2 publication Critical patent/FR2378094B2/fr
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Biological reagents for the diagnosis of specific illnesses and pathological states, have a specific antibody contg. a glucoprotein on an insoluble support which may be a polymer esp. a latex, a dextran or agar gel, or activated glass, pref. in the form of balls or micro-balls. The support carries a side chain on which is covalently fixed an amine, polyamine, diacid, aminoacid, or an aromatic or aliphatic hydrazine, opt. with an acid function and opt. themselves coupled through-NH2 to an aliphatic or aromatic amine or hydrazine, an amino acid, and opt. carrying an -SH or -NH2 gp. and capable of forming a heterocycle in the presence of an aldehyde gp. on the antibody fixed on the support. Reagent has good stability and sensitivity. typically it is used to test for measles, German measles, influenza, cytomegalic virus, Carres disease. The antibody may be a fibrinogen degradation gammaglobulin byproduct, or a hormone esp. human chlorionic gonadotrophin.
FR7701889A 1977-01-24 1977-01-24 Biological reagent for diagnosis of specific illnesses - having an oxidised gluco-protein antibody on an insoluble support Granted FR2378094A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7701889A FR2378094A2 (en) 1977-01-24 1977-01-24 Biological reagent for diagnosis of specific illnesses - having an oxidised gluco-protein antibody on an insoluble support

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7701889A FR2378094A2 (en) 1977-01-24 1977-01-24 Biological reagent for diagnosis of specific illnesses - having an oxidised gluco-protein antibody on an insoluble support

Publications (2)

Publication Number Publication Date
FR2378094A2 true FR2378094A2 (en) 1978-08-18
FR2378094B2 FR2378094B2 (en) 1980-06-20

Family

ID=9185823

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7701889A Granted FR2378094A2 (en) 1977-01-24 1977-01-24 Biological reagent for diagnosis of specific illnesses - having an oxidised gluco-protein antibody on an insoluble support

Country Status (1)

Country Link
FR (1) FR2378094A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987003206A1 (en) * 1985-11-25 1987-06-04 Quash Gerard A Modified viral glycoproteins, diagnostic and therapeutic uses therefore
US4965069A (en) * 1985-11-25 1990-10-23 Quash Gerard A Oxidized viruses or viral antigens and utilization for diagnostic prophylactic and/or therapeutic applications
EP1762250A1 (en) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine
US7538092B2 (en) 2002-10-08 2009-05-26 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
US7541328B2 (en) 2002-03-06 2009-06-02 Fresenius Kabi Deutschland Gmbh Coupling proteins to a modified polysaccharide

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2450877A1 (en) 1979-03-06 1980-10-03 Inst Nat Sante Rech Med NEW AGGLUTINATION TESTS FOR THE DETECTION OF INFLUENZA VIRUSES, AND REAGENTS FOR PERFORMING THESE TESTS
DE10112825A1 (en) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylation of active ingredients in aqueous solution
DE10209822A1 (en) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Coupling of low molecular weight substances to a modified polysaccharide
CA2496317C (en) 2002-09-11 2014-02-18 Fresenius Kabi Deutschland Gmbh Method of producing hydroxyalkyl starch derivatives
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
SG151261A1 (en) 2004-03-11 2009-04-30 Fresenius Kabi De Gmbh Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
EP2070950A1 (en) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987003206A1 (en) * 1985-11-25 1987-06-04 Quash Gerard A Modified viral glycoproteins, diagnostic and therapeutic uses therefore
US4965069A (en) * 1985-11-25 1990-10-23 Quash Gerard A Oxidized viruses or viral antigens and utilization for diagnostic prophylactic and/or therapeutic applications
US7541328B2 (en) 2002-03-06 2009-06-02 Fresenius Kabi Deutschland Gmbh Coupling proteins to a modified polysaccharide
US7538092B2 (en) 2002-10-08 2009-05-26 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
EP1762250A1 (en) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine
WO2007031266A3 (en) * 2005-09-12 2007-09-20 Fresenius Kabi De Gmbh Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine
JP2009507973A (en) * 2005-09-12 2009-02-26 フレゼニウス・カビ・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Conjugates of hydroxyalkyl starch and active substance prepared by chemical coupling via thiazolidine
EA013910B1 (en) * 2005-09-12 2010-08-30 Фрезениус Каби Дойчланд Гмбх Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine
AU2006291527B2 (en) * 2005-09-12 2012-03-22 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine

Also Published As

Publication number Publication date
FR2378094B2 (en) 1980-06-20

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