FR2374293A2 - Pharmaceutical halobenzene prepn. - by reacting halo-aniline with alcohol and nitrating agent in presence of aq. acid - Google Patents
Pharmaceutical halobenzene prepn. - by reacting halo-aniline with alcohol and nitrating agent in presence of aq. acidInfo
- Publication number
- FR2374293A2 FR2374293A2 FR7737474A FR7737474A FR2374293A2 FR 2374293 A2 FR2374293 A2 FR 2374293A2 FR 7737474 A FR7737474 A FR 7737474A FR 7737474 A FR7737474 A FR 7737474A FR 2374293 A2 FR2374293 A2 FR 2374293A2
- Authority
- FR
- France
- Prior art keywords
- acid
- prepn
- formula
- reacting
- aniline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
- C07C63/70—Monocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Prepn. of halobenzenes of formula (I) is described. In the formula, R1 and R4 are each halo; R3 is NO2 or COOR5 (where R5 is H, or a (cyclo)aliphatic, araliphatic or aromatic gp.), R4 can also be H, or when R3 is COOR5, R4 can be NO2. Process comprises (i) reacting an aniline of formula (III) with a halogenating agent in the presence of H2O and an acid, giving a haloaniline of formula (II); and (ii) without isolating the reaction mixt., reacting cpd. (II) with (cyclo)aliphatic or araliphatic alcohols and nitrating agents in the presence of an acid, and with addn. of H2O, at 35 degrees C. Cpd. (I) can also be prepd. by reacting a haloaminobenzoic acid or deriv., of formula (IV), with (cyclo)aliphatic or araliphatic alcohols and nitrating agents, in the presence of an acid and with addn. of H2O, at >=35 degrees C. (I) are used e.g. in the prepn. of medicines, dyes and pesticides. High yields and purity are obtd.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19762657234 DE2657234C3 (en) | 1976-12-17 | 1976-12-17 | Process for the production of halonitrobenzenes |
DE19762659149 DE2659149A1 (en) | 1976-12-28 | 1976-12-28 | Ester(s) of crotonic or butyric acid - contg. cyclic or poly-cyclic rings, have useful odoriferous properties |
DE19772721133 DE2721133C2 (en) | 1977-05-11 | 1977-05-11 | Process for the preparation of halobenzoic acid compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2374293A2 true FR2374293A2 (en) | 1978-07-13 |
FR2374293B2 FR2374293B2 (en) | 1984-09-21 |
Family
ID=27187061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7737474A Granted FR2374293A2 (en) | 1976-12-17 | 1977-12-13 | Pharmaceutical halobenzene prepn. - by reacting halo-aniline with alcohol and nitrating agent in presence of aq. acid |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2374293A2 (en) |
-
1977
- 1977-12-13 FR FR7737474A patent/FR2374293A2/en active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2374293B2 (en) | 1984-09-21 |
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