FR2371198A2 - (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc. - Google Patents
(6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc.Info
- Publication number
- FR2371198A2 FR2371198A2 FR7635096A FR7635096A FR2371198A2 FR 2371198 A2 FR2371198 A2 FR 2371198A2 FR 7635096 A FR7635096 A FR 7635096A FR 7635096 A FR7635096 A FR 7635096A FR 2371198 A2 FR2371198 A2 FR 2371198A2
- Authority
- FR
- France
- Prior art keywords
- tranquillisers
- hypnotics
- carbonyloxy
- dithiepino
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
Abstract
Dithiepino-pyrrole derivs. of formula (I) and their acids addn. salts are new: (A=phenyl, 2-pyridyl, 2-quinolyl, or 1,8-naphthyridin-2-yl; all opt. substd. by a halo, 1-4C alkyl or alkoxy, CN or NO2. R=H, 1-4C alkl or alkanoyl, or 2-4C alkenyl) They are prepd. e.g. by reacting a 4-(chlorocarbonyl)-1-R-piperazine with the corresp. 6-hydroxy dithiepino-pyrrole. (I) are useful as tranquillisers, anti-convulsants, hypnotics and muscle relaxants, generally given at 10-500 mg/day (oral adult dose). Their LD50 (orally in mice) is generally >0.9g/kg. A typical cpd. is 6-(4-methylpiperazino)carbonyloxy-7-(4-nitrophenyl).8-Oxo-3,4,7,8- -tetrahydro-2H, 6H-dithiepino (1,4) (2,3-c) pyrrole.
Priority Applications (33)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7635096A FR2371198A2 (en) | 1976-11-22 | 1976-11-22 | (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc. |
CA271,424A CA1072557A (en) | 1976-02-20 | 1977-02-09 | Dithiepinno (1,4)(2,3-c) pyrrol; methods of preparation, compositions thereof |
NL7701487A NL7701487A (en) | 1976-02-20 | 1977-02-11 | NEW DITHIEPINO (1.4) (2.3-C) PYRROOL DERIVES, METHODS FOR PREPARING THEM AND PREPARATIONS CONTAINING THE NEW PREPARATIONS. |
JP1664577A JPS52100495A (en) | 1976-02-20 | 1977-02-17 | Dithiepino*1*4**2*33c*pyrrole process for preparing same and medical composition |
AU22401/77A AU503745B2 (en) | 1976-02-20 | 1977-02-17 | Derivatives of dithiepino (1, 4) (2, 3-c) pyrrole |
IE335/77A IE44564B1 (en) | 1976-02-20 | 1977-02-17 | Derivatives of dithiepino (1,4) (2,3-c)pyrrole |
PH19463A PH12628A (en) | 1976-02-20 | 1977-02-17 | Derivatives of dithxepino(1,4)(2,3c)pyrrole and pharmaceutical composition containing same |
NZ183366A NZ183366A (en) | 1976-02-20 | 1977-02-17 | 6-piperazine-1'-ylcarbonyl-oxy-7-substituted-8-oxo-3,4,7,8-tetrahydro-2h,6h-dithiepino (1,4) (38-c) pyrroles |
US05/769,737 US4124711A (en) | 1976-02-20 | 1977-02-17 | Derivatives of dithiepino[1,4][2,3-C]pyrrole |
GB6758/77A GB1512620A (en) | 1976-02-20 | 1977-02-17 | Derivatives of dithiepino(1,4)(2,3-c)pyrrole |
SU772453398A SU869559A3 (en) | 1976-02-20 | 1977-02-18 | Method of preparing (1,4)-dithiepino (2,3-c)-pyrrole or its salts |
CH208377A CH620443A5 (en) | 1976-02-20 | 1977-02-18 | |
AT109977A AT350577B (en) | 1976-02-20 | 1977-02-18 | PROCESS FOR THE PREPARATION OF NEW PIPERAZINE DERIVATIVES OF DITHIEPINO (1,4) (2,3-C) PYRROLS AND THEIR ACID ADDITION SALTS |
YU458/77A YU39990B (en) | 1976-02-20 | 1977-02-18 | Process for obtaining new ditiepino(1,4)(2,3-c)-pyrrol derivatives |
PT66203A PT66203B (en) | 1976-02-20 | 1977-02-18 | PROCESS FOR THE PREPARATION OF DITIEPINO / 1,4 / 2,3-C / PIRROLE DERIVATIVES AND COMPOSITIONS CONTAINING THEM |
FI770530A FI61190C (en) | 1976-02-20 | 1977-02-18 | REFERENCE FOR THERAPEUTIC ADMINISTRATION OF THERAPEUTIC ANVAENDBARA 6- (PIPERAZIN-1-YL) CARBONYLOXY-8-OXO-3,4,7,8-TETRAHYDRO-2H 6H- (1,4) -DITIEPINO (2,3-C) -PYRRODE DERIVATIVES |
ES456041A ES456041A1 (en) | 1976-02-20 | 1977-02-18 | Derivatives of dithiepino{8 1,4{9 {8 2,3-C{9 pyrrole |
HU77RO00000916A HU172292B (en) | 1976-02-20 | 1977-02-18 | Process for preparing new derivatives of the dithiepino/1,4/2,3-c/pyrrole |
DE2707072A DE2707072C2 (en) | 1976-02-20 | 1977-02-18 | Derivatives of dithiepino [1,4] [2,3-c] pyrrole, their preparation and compositions containing them |
LU76799A LU76799A1 (en) | 1976-02-20 | 1977-02-18 | |
DK71877A DK146069C (en) | 1976-02-20 | 1977-02-18 | ANALOGY PROCEDURE FOR PREPARING DERIVATIVES OF DITHIEPINO- (1,4) (2,3-C) -PYRROL |
SE7701843A SE427353B (en) | 1976-02-20 | 1977-02-18 | PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE DERIVATIVES OF DITIEPINO- (1,4) (2,3-C) -PYRROL |
NO770552A NO145539C (en) | 1976-02-20 | 1977-02-18 | ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTIC ACTIVE DERIVATIVES OF DITIEPINO (1,4) (2,3-C) PYRROL |
ES457262A ES457262A1 (en) | 1976-11-22 | 1977-03-28 | (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc. |
ES77457261A ES457261A1 (en) | 1976-11-22 | 1977-03-28 | (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc. |
ES457260A ES457260A1 (en) | 1976-02-20 | 1977-03-28 | Derivatives of dithiepino{8 1,4{9 {8 2,3-C{9 pyrrole |
AR268663A AR218261A1 (en) | 1976-02-20 | 1977-08-02 | PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF PIPERAZINYL CARBONILOXI-6 OXO-8 DIHIDRO-6,7, DITIEPINO (1,4) (2,3-C) PIRROL AND ITS SALTS |
AR26866477A AR214085A1 (en) | 1976-11-22 | 1977-08-02 | PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF PIPERAZINYL CARBONYLOXY-6 OXO-8 DIHYDRO-6,7 DITIEPINE (1,4) (2,3-C) PIRROL AND ITS SALTS |
SU782567451D SU674672A3 (en) | 1976-02-20 | 1978-01-17 | Method of obtaining /1,4/-dithiepino(2,3-c)-pyrrole derivatives or salts thereof |
SU782569898A SU856386A3 (en) | 1976-11-22 | 1978-01-17 | Method of preparing derivatives of 1,4-dithiepino-/2,3-c/-pyrrol or their salts |
AT586278A AT353800B (en) | 1976-02-20 | 1978-08-11 | PROCESS FOR THE PREPARATION OF NEW PIPERAZINE DERIVATIVES OF DITHIEPINO (1,4) (2,3-C) PYRROLS AND THEIR ACID ADDITION SALTS |
YU1627/82A YU40082B (en) | 1976-02-20 | 1982-07-23 | Procss for obtaining new dithiepino (,4)(2,3-c)-pyrrol derivatives |
YU162882A YU40083B (en) | 1976-11-22 | 1982-07-23 | Process for obtaining new ditiepino (1,4)(2,3-c)-pyrrol derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7635096A FR2371198A2 (en) | 1976-11-22 | 1976-11-22 | (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2371198A2 true FR2371198A2 (en) | 1978-06-16 |
FR2371198B2 FR2371198B2 (en) | 1979-09-28 |
Family
ID=9180144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7635096A Granted FR2371198A2 (en) | 1976-02-20 | 1976-11-22 | (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc. |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR214085A1 (en) |
ES (2) | ES457262A1 (en) |
FR (1) | FR2371198A2 (en) |
SU (1) | SU856386A3 (en) |
YU (1) | YU40083B (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2550111A1 (en) * | 1974-11-07 | 1976-05-13 | Rhone Poulenc Ind | NEW HETEROCYCLIC COMPOUNDS, PROCEDURES FOR THEIR PRODUCTION AND COMPOSITIONS THEREOF |
-
1976
- 1976-11-22 FR FR7635096A patent/FR2371198A2/en active Granted
-
1977
- 1977-03-28 ES ES457262A patent/ES457262A1/en not_active Expired
- 1977-03-28 ES ES77457261A patent/ES457261A1/en not_active Expired
- 1977-08-02 AR AR26866477A patent/AR214085A1/en active
-
1978
- 1978-01-17 SU SU782569898A patent/SU856386A3/en active
-
1982
- 1982-07-23 YU YU162882A patent/YU40083B/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2550111A1 (en) * | 1974-11-07 | 1976-05-13 | Rhone Poulenc Ind | NEW HETEROCYCLIC COMPOUNDS, PROCEDURES FOR THEIR PRODUCTION AND COMPOSITIONS THEREOF |
Also Published As
Publication number | Publication date |
---|---|
ES457262A1 (en) | 1978-02-01 |
AR214085A1 (en) | 1979-04-30 |
FR2371198B2 (en) | 1979-09-28 |
SU856386A3 (en) | 1981-08-15 |
YU162882A (en) | 1982-10-31 |
ES457261A1 (en) | 1978-02-01 |
YU40083B (en) | 1985-06-30 |
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