FR2341312A1 - (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc. - Google Patents

(6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc.

Info

Publication number
FR2341312A1
FR2341312A1 FR7604713A FR7604713A FR2341312A1 FR 2341312 A1 FR2341312 A1 FR 2341312A1 FR 7604713 A FR7604713 A FR 7604713A FR 7604713 A FR7604713 A FR 7604713A FR 2341312 A1 FR2341312 A1 FR 2341312A1
Authority
FR
France
Prior art keywords
tranquillisers
hypnotics
carbonyloxy
dithiepino
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7604713A
Other languages
French (fr)
Other versions
FR2341312B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7604713A priority Critical patent/FR2341312A1/en
Priority to CA271,424A priority patent/CA1072557A/en
Priority to NL7701487A priority patent/NL7701487A/en
Priority to PH19463A priority patent/PH12628A/en
Priority to IE335/77A priority patent/IE44564B1/en
Priority to JP1664577A priority patent/JPS52100495A/en
Priority to NZ183366A priority patent/NZ183366A/en
Priority to US05/769,737 priority patent/US4124711A/en
Priority to GB6758/77A priority patent/GB1512620A/en
Priority to AU22401/77A priority patent/AU503745B2/en
Priority to ZA00770972A priority patent/ZA77972B/en
Priority to SU772453398A priority patent/SU869559A3/en
Priority to NO770552A priority patent/NO145539C/en
Priority to DK71877A priority patent/DK146069C/en
Priority to PT66203A priority patent/PT66203B/en
Priority to LU76799A priority patent/LU76799A1/xx
Priority to ES456041A priority patent/ES456041A1/en
Priority to DE2707072A priority patent/DE2707072C2/en
Priority to AT109977A priority patent/AT350577B/en
Priority to SE7701843A priority patent/SE427353B/en
Priority to YU458/77A priority patent/YU39990B/en
Priority to CH208377A priority patent/CH620443A5/fr
Priority to BE175095A priority patent/BE851621A/en
Priority to FI770530A priority patent/FI61190C/en
Priority to HU77RO00000916A priority patent/HU172292B/en
Priority to ES457260A priority patent/ES457260A1/en
Priority to AR268663A priority patent/AR218261A1/en
Publication of FR2341312A1 publication Critical patent/FR2341312A1/en
Priority to SU782567451D priority patent/SU674672A3/en
Priority to AT586278A priority patent/AT353800B/en
Application granted granted Critical
Publication of FR2341312B1 publication Critical patent/FR2341312B1/fr
Priority to YU1627/82A priority patent/YU40082B/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dithiepino-pyrrole derivs. of formula (I) and their acids addn. salts are new: (A=phenyl, 2-pyridyl, 2-quinolyl, or 1,8-naphthyridin-2-yl; all opt. substd. by a halo, 1-4C alkyl or alkoxy, CN or NO2. R=H, 1-4C alkl or alkanoyl, or 2-4C alkenyl) They are prepd. e.g. by reacting a 4-(chlorocarbonyl)-1-R-piperazine with the corresp. 6-hydroxy dithiepino-pyrrole. (I) are useful as tranquillisers, anti-convulsants, hypnotics and muscle relaxants, generally given at 10-500 mg/day (oral adult dose). Their LD50 (orally in mice) is generally >0.9g/kg. A typical cpd. is 6-(4-methylpiperazino)carbonyloxy-7-(4-nitrophenyl).8-Oxo-3,4,7,8- -tetrahydro-2H, 6H-dithiepino (1,4) (2,3-c) pyrrole.
FR7604713A 1976-02-20 1976-02-20 (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc. Granted FR2341312A1 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
FR7604713A FR2341312A1 (en) 1976-02-20 1976-02-20 (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc.
CA271,424A CA1072557A (en) 1976-02-20 1977-02-09 Dithiepinno (1,4)(2,3-c) pyrrol; methods of preparation, compositions thereof
NL7701487A NL7701487A (en) 1976-02-20 1977-02-11 NEW DITHIEPINO (1.4) (2.3-C) PYRROOL DERIVES, METHODS FOR PREPARING THEM AND PREPARATIONS CONTAINING THE NEW PREPARATIONS.
IE335/77A IE44564B1 (en) 1976-02-20 1977-02-17 Derivatives of dithiepino (1,4) (2,3-c)pyrrole
JP1664577A JPS52100495A (en) 1976-02-20 1977-02-17 Dithiepino*1*4**2*33c*pyrrole process for preparing same and medical composition
NZ183366A NZ183366A (en) 1976-02-20 1977-02-17 6-piperazine-1'-ylcarbonyl-oxy-7-substituted-8-oxo-3,4,7,8-tetrahydro-2h,6h-dithiepino (1,4) (38-c) pyrroles
US05/769,737 US4124711A (en) 1976-02-20 1977-02-17 Derivatives of dithiepino[1,4][2,3-C]pyrrole
GB6758/77A GB1512620A (en) 1976-02-20 1977-02-17 Derivatives of dithiepino(1,4)(2,3-c)pyrrole
AU22401/77A AU503745B2 (en) 1976-02-20 1977-02-17 Derivatives of dithiepino (1, 4) (2, 3-c) pyrrole
ZA00770972A ZA77972B (en) 1976-02-20 1977-02-17 Derivatives of dithiepino(1,4)(2,3-c)pyrrole
PH19463A PH12628A (en) 1976-02-20 1977-02-17 Derivatives of dithxepino(1,4)(2,3c)pyrrole and pharmaceutical composition containing same
BE175095A BE851621A (en) 1976-02-20 1977-02-18 NEW DITHIEPINNO (1,4) (2,3, -C) PYRROLE DERIVATIVES
DK71877A DK146069C (en) 1976-02-20 1977-02-18 ANALOGY PROCEDURE FOR PREPARING DERIVATIVES OF DITHIEPINO- (1,4) (2,3-C) -PYRROL
PT66203A PT66203B (en) 1976-02-20 1977-02-18 PROCESS FOR THE PREPARATION OF DITIEPINO / 1,4 / 2,3-C / PIRROLE DERIVATIVES AND COMPOSITIONS CONTAINING THEM
SU772453398A SU869559A3 (en) 1976-02-20 1977-02-18 Method of preparing (1,4)-dithiepino (2,3-c)-pyrrole or its salts
ES456041A ES456041A1 (en) 1976-02-20 1977-02-18 Derivatives of dithiepino{8 1,4{9 {8 2,3-C{9 pyrrole
DE2707072A DE2707072C2 (en) 1976-02-20 1977-02-18 Derivatives of dithiepino [1,4] [2,3-c] pyrrole, their preparation and compositions containing them
AT109977A AT350577B (en) 1976-02-20 1977-02-18 PROCESS FOR THE PREPARATION OF NEW PIPERAZINE DERIVATIVES OF DITHIEPINO (1,4) (2,3-C) PYRROLS AND THEIR ACID ADDITION SALTS
SE7701843A SE427353B (en) 1976-02-20 1977-02-18 PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE DERIVATIVES OF DITIEPINO- (1,4) (2,3-C) -PYRROL
YU458/77A YU39990B (en) 1976-02-20 1977-02-18 Process for obtaining new ditiepino(1,4)(2,3-c)-pyrrol derivatives
CH208377A CH620443A5 (en) 1976-02-20 1977-02-18
NO770552A NO145539C (en) 1976-02-20 1977-02-18 ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTIC ACTIVE DERIVATIVES OF DITIEPINO (1,4) (2,3-C) PYRROL
FI770530A FI61190C (en) 1976-02-20 1977-02-18 REFERENCE FOR THERAPEUTIC ADMINISTRATION OF THERAPEUTIC ANVAENDBARA 6- (PIPERAZIN-1-YL) CARBONYLOXY-8-OXO-3,4,7,8-TETRAHYDRO-2H 6H- (1,4) -DITIEPINO (2,3-C) -PYRRODE DERIVATIVES
HU77RO00000916A HU172292B (en) 1976-02-20 1977-02-18 Process for preparing new derivatives of the dithiepino/1,4/2,3-c/pyrrole
LU76799A LU76799A1 (en) 1976-02-20 1977-02-18
ES457260A ES457260A1 (en) 1976-02-20 1977-03-28 Derivatives of dithiepino{8 1,4{9 {8 2,3-C{9 pyrrole
AR268663A AR218261A1 (en) 1976-02-20 1977-08-02 PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF PIPERAZINYL CARBONILOXI-6 OXO-8 DIHIDRO-6,7, DITIEPINO (1,4) (2,3-C) PIRROL AND ITS SALTS
SU782567451D SU674672A3 (en) 1976-02-20 1978-01-17 Method of obtaining /1,4/-dithiepino(2,3-c)-pyrrole derivatives or salts thereof
AT586278A AT353800B (en) 1976-02-20 1978-08-11 PROCESS FOR THE PREPARATION OF NEW PIPERAZINE DERIVATIVES OF DITHIEPINO (1,4) (2,3-C) PYRROLS AND THEIR ACID ADDITION SALTS
YU1627/82A YU40082B (en) 1976-02-20 1982-07-23 Procss for obtaining new dithiepino (,4)(2,3-c)-pyrrol derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7604713A FR2341312A1 (en) 1976-02-20 1976-02-20 (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc.

Publications (2)

Publication Number Publication Date
FR2341312A1 true FR2341312A1 (en) 1977-09-16
FR2341312B1 FR2341312B1 (en) 1979-07-20

Family

ID=9169385

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7604713A Granted FR2341312A1 (en) 1976-02-20 1976-02-20 (6)-Piperazino-carbonyloxy-dithiepinopyrroles - useful as tranquillisers, anticonvulsants, hypnotics etc.

Country Status (3)

Country Link
BE (1) BE851621A (en)
FR (1) FR2341312A1 (en)
ZA (1) ZA77972B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327095A (en) * 1979-03-15 1982-04-27 Rhone-Poulenc Industries Methoxy derivatives of 1,4-dithiepino-[2,3-c]-pyrrole

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327095A (en) * 1979-03-15 1982-04-27 Rhone-Poulenc Industries Methoxy derivatives of 1,4-dithiepino-[2,3-c]-pyrrole

Also Published As

Publication number Publication date
ZA77972B (en) 1978-01-25
BE851621A (en) 1977-08-18
FR2341312B1 (en) 1979-07-20

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