FR2368280A1 - Nouvelle composition therapeutique presentant une activite anti-agregante plaquettaire, et son procede de preparation - Google Patents
Nouvelle composition therapeutique presentant une activite anti-agregante plaquettaire, et son procede de preparationInfo
- Publication number
- FR2368280A1 FR2368280A1 FR7631561A FR7631561A FR2368280A1 FR 2368280 A1 FR2368280 A1 FR 2368280A1 FR 7631561 A FR7631561 A FR 7631561A FR 7631561 A FR7631561 A FR 7631561A FR 2368280 A1 FR2368280 A1 FR 2368280A1
- Authority
- FR
- France
- Prior art keywords
- dipyridamole
- platelet aggregation
- blood platelet
- aspirin
- inhibitory activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 title abstract 3
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical class C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001138 acetylsalicylic acid Drugs 0.000 title 1
- 210000001772 blood platelet Anatomy 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 title 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 2
- 229960002768 dipyridamole Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7631561A FR2368280A1 (fr) | 1976-10-20 | 1976-10-20 | Nouvelle composition therapeutique presentant une activite anti-agregante plaquettaire, et son procede de preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7631561A FR2368280A1 (fr) | 1976-10-20 | 1976-10-20 | Nouvelle composition therapeutique presentant une activite anti-agregante plaquettaire, et son procede de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2368280A1 true FR2368280A1 (fr) | 1978-05-19 |
| FR2368280B1 FR2368280B1 (OSRAM) | 1980-10-03 |
Family
ID=9178998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7631561A Granted FR2368280A1 (fr) | 1976-10-20 | 1976-10-20 | Nouvelle composition therapeutique presentant une activite anti-agregante plaquettaire, et son procede de preparation |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2368280A1 (OSRAM) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2513118A1 (fr) * | 1981-09-18 | 1983-03-25 | Rocador Sa | Composition pharmaceutique a base de dipyridamol et de sel d'aluminium de l'acide acetylsalicylique pour combattre l'agregation plaquettaire |
| DE3623331A1 (de) * | 1986-07-11 | 1988-01-21 | Hoechst Ag | Konfektionspackungen, enthaltend arzneimittelkombinationen fuer zeitlich abgestufte anwendung |
| EP0257344A1 (de) * | 1986-08-13 | 1988-03-02 | Dr. Karl Thomae GmbH | Arzneimittel enthaltend Dipyridamol oder Mopidamol und O-Acetylsalicylsäure bzw. deren physiologisch verträgliche Salze, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung der Thrombusbildung |
| WO1998057643A1 (en) * | 1997-06-16 | 1998-12-23 | Janssen Pharmaceutica N.V. | Use of draflazine-analogues for treating pain |
-
1976
- 1976-10-20 FR FR7631561A patent/FR2368280A1/fr active Granted
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2513118A1 (fr) * | 1981-09-18 | 1983-03-25 | Rocador Sa | Composition pharmaceutique a base de dipyridamol et de sel d'aluminium de l'acide acetylsalicylique pour combattre l'agregation plaquettaire |
| DE3623331A1 (de) * | 1986-07-11 | 1988-01-21 | Hoechst Ag | Konfektionspackungen, enthaltend arzneimittelkombinationen fuer zeitlich abgestufte anwendung |
| US4850489A (en) * | 1986-07-11 | 1989-07-25 | Hoechst Aktiengesellschaft | Dispensing packs containing pharmaceutical combinations for sequential administration |
| EP0257344A1 (de) * | 1986-08-13 | 1988-03-02 | Dr. Karl Thomae GmbH | Arzneimittel enthaltend Dipyridamol oder Mopidamol und O-Acetylsalicylsäure bzw. deren physiologisch verträgliche Salze, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung der Thrombusbildung |
| US6015577A (en) * | 1986-08-13 | 2000-01-18 | Dr. Karl Thomae GmbH | Pharmaceutical compositions containing dipyridamole or mopidamol and acetylsalicylic acid or the physiologically acceptable salts thereof, processes for preparing them and their use in treating clot formation |
| WO1998057643A1 (en) * | 1997-06-16 | 1998-12-23 | Janssen Pharmaceutica N.V. | Use of draflazine-analogues for treating pain |
| US6403589B1 (en) | 1997-06-16 | 2002-06-11 | Janssen Pharmaceutica N.V. | Method of treating pain with draflazine-analogues |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2368280B1 (OSRAM) | 1980-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| ST | Notification of lapse |