FR2368278A1 - Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periods - Google Patents

Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periods

Info

Publication number
FR2368278A1
FR2368278A1 FR7632162A FR7632162A FR2368278A1 FR 2368278 A1 FR2368278 A1 FR 2368278A1 FR 7632162 A FR7632162 A FR 7632162A FR 7632162 A FR7632162 A FR 7632162A FR 2368278 A1 FR2368278 A1 FR 2368278A1
Authority
FR
France
Prior art keywords
triazine
cpds
analgesic
treatment
long periods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7632162A
Other languages
French (fr)
Other versions
FR2368278B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7632162A priority Critical patent/FR2368278A1/en
Publication of FR2368278A1 publication Critical patent/FR2368278A1/en
Application granted granted Critical
Publication of FR2368278B1 publication Critical patent/FR2368278B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Analgesic compsns. contain as active constituents, a cpd. of formula (I) (where X and Y are H, halo, alkyl, alkenyl, NO2, OH or methylenedioxy, n is 1,2 or 3, A is O or S, when the double bond is in the 3,3' R is H, aryl, alkyl or alkenyl, when the double bond is in the 2,3 position, R1 is H or alkyl, provided that when -AR1 is OH or -Oalkyl X and Y are not both H). Some cpds. (I) are claimed per se, including 3-oxo-2-methyl-5,6-di-(4-methoxyphenyl)-1,2,4-triazine, to 3-thioanalogue and 3-hydroxy-5-(4-methoxyphenyl)-6-(2-chlorophenyl)-1,2,4-triazine. Used for treatment of severe pain for long periods because of low toxicity and side-effect incidence.
FR7632162A 1976-10-25 1976-10-25 Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periods Granted FR2368278A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7632162A FR2368278A1 (en) 1976-10-25 1976-10-25 Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periods

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7632162A FR2368278A1 (en) 1976-10-25 1976-10-25 Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periods

Publications (2)

Publication Number Publication Date
FR2368278A1 true FR2368278A1 (en) 1978-05-19
FR2368278B1 FR2368278B1 (en) 1980-09-19

Family

ID=9179183

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7632162A Granted FR2368278A1 (en) 1976-10-25 1976-10-25 Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periods

Country Status (1)

Country Link
FR (1) FR2368278A1 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2391202A1 (en) * 1977-05-17 1978-12-15 Diamond Shamrock Corp SUBSTITUTED, PHARMACOLOGICALLY ACTIVE TRIAZINES-1,2,4 AND MEDICINAL PRODUCTS CONTAINING THESE TRIAZINES
FR2477873A1 (en) * 1980-03-17 1981-09-18 Fabre Sa Pierre 5,6-Di:aryl 1,2,4-triazine cpds. used as solar filters - prepd. from di:aryl di:ketone(s) and semicarbazide cpds.
FR2478095A1 (en) * 1980-03-14 1981-09-18 Fabre Sa Pierre CETONIC DERIVATIVES OF DIARYL 5-6 1-2-4 ANTALGIC AND ANTIAGRANT TRIAZINES FOR THE TREATMENT OF MIGRAINE BACKGROUND
FR2500830A1 (en) * 1981-03-02 1982-09-03 Fabre Sa Pierre 2-Substd. 1,2,4-triazin-3-one(s) - having analgesic properties, prepd. by alkylating 2-unsubstituted triazinone
EP0099438A1 (en) * 1982-07-20 1984-02-01 Pierre Fabre S.A. 2-Functionalised diaryl as-triazines useful in therapy
FR2544313A1 (en) * 1983-04-14 1984-10-19 Fabre Sa Pierre N-CYCLOALCOYL METHYL-2-OXO-3-DIARYL 5-6 AS TRIAZINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS A MEDICINAL PRODUCT
EP0194572A1 (en) * 1985-03-12 1986-09-17 Hoechst Aktiengesellschaft Heterocyclic sulfides, process for their preparation and Medicaments containing them
US4677105A (en) * 1985-02-04 1987-06-30 Pf Medicament 2-alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-triazines having utility as therapeutics
US5728698A (en) * 1990-09-21 1998-03-17 Rohm And Haas Company Dihydropyridazinones, pyridazinones and related compounds as fungicides
WO2008141013A1 (en) * 2007-05-08 2008-11-20 Allergan, Inc. S1p3 receptor inhibitors for treating pain
AU2006202334B2 (en) * 2005-06-01 2010-01-21 Schneider Electric New Zealand Holdings Limited An Electric Fitting
CN113134005A (en) * 2020-01-16 2021-07-20 中国药科大学 Application of TRPV1 channel targeting small molecule

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2391202A1 (en) * 1977-05-17 1978-12-15 Diamond Shamrock Corp SUBSTITUTED, PHARMACOLOGICALLY ACTIVE TRIAZINES-1,2,4 AND MEDICINAL PRODUCTS CONTAINING THESE TRIAZINES
FR2478095A1 (en) * 1980-03-14 1981-09-18 Fabre Sa Pierre CETONIC DERIVATIVES OF DIARYL 5-6 1-2-4 ANTALGIC AND ANTIAGRANT TRIAZINES FOR THE TREATMENT OF MIGRAINE BACKGROUND
EP0036357A1 (en) * 1980-03-14 1981-09-23 Pierre Fabre S.A. Antalgic and antiagregant cetonic derivatives of 5,6-diaryl-1,2,4-triazines, usable in the treatment of migraine
FR2477873A1 (en) * 1980-03-17 1981-09-18 Fabre Sa Pierre 5,6-Di:aryl 1,2,4-triazine cpds. used as solar filters - prepd. from di:aryl di:ketone(s) and semicarbazide cpds.
FR2500830A1 (en) * 1981-03-02 1982-09-03 Fabre Sa Pierre 2-Substd. 1,2,4-triazin-3-one(s) - having analgesic properties, prepd. by alkylating 2-unsubstituted triazinone
EP0099438A1 (en) * 1982-07-20 1984-02-01 Pierre Fabre S.A. 2-Functionalised diaryl as-triazines useful in therapy
US4511566A (en) * 1983-04-14 1985-04-16 Pierre Fabre S.A. 2-N-Cycloalkylmethyl 3-oxo 5,6-diaryl-as-triazines
EP0123605A1 (en) * 1983-04-14 1984-10-31 Pierre Fabre S.A. N-Cyclopropylmethyl-2-oxo-3-diparamethoxyphenyl-5,6-triazines, process for its preparation and their use as pharmaceutical preparations
FR2544313A1 (en) * 1983-04-14 1984-10-19 Fabre Sa Pierre N-CYCLOALCOYL METHYL-2-OXO-3-DIARYL 5-6 AS TRIAZINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS A MEDICINAL PRODUCT
US4677105A (en) * 1985-02-04 1987-06-30 Pf Medicament 2-alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-triazines having utility as therapeutics
EP0194572A1 (en) * 1985-03-12 1986-09-17 Hoechst Aktiengesellschaft Heterocyclic sulfides, process for their preparation and Medicaments containing them
US4762848A (en) * 1985-03-12 1988-08-09 Hoechst Aktiengesellschaft 1,3-thiazoles and their use as immunomodulators
US5728698A (en) * 1990-09-21 1998-03-17 Rohm And Haas Company Dihydropyridazinones, pyridazinones and related compounds as fungicides
AU2006202334B2 (en) * 2005-06-01 2010-01-21 Schneider Electric New Zealand Holdings Limited An Electric Fitting
WO2008141013A1 (en) * 2007-05-08 2008-11-20 Allergan, Inc. S1p3 receptor inhibitors for treating pain
CN113134005A (en) * 2020-01-16 2021-07-20 中国药科大学 Application of TRPV1 channel targeting small molecule

Also Published As

Publication number Publication date
FR2368278B1 (en) 1980-09-19

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