FR2368278A1 - Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periods - Google Patents
Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periodsInfo
- Publication number
- FR2368278A1 FR2368278A1 FR7632162A FR7632162A FR2368278A1 FR 2368278 A1 FR2368278 A1 FR 2368278A1 FR 7632162 A FR7632162 A FR 7632162A FR 7632162 A FR7632162 A FR 7632162A FR 2368278 A1 FR2368278 A1 FR 2368278A1
- Authority
- FR
- France
- Prior art keywords
- triazine
- cpds
- analgesic
- treatment
- long periods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Analgesic compsns. contain as active constituents, a cpd. of formula (I) (where X and Y are H, halo, alkyl, alkenyl, NO2, OH or methylenedioxy, n is 1,2 or 3, A is O or S, when the double bond is in the 3,3' R is H, aryl, alkyl or alkenyl, when the double bond is in the 2,3 position, R1 is H or alkyl, provided that when -AR1 is OH or -Oalkyl X and Y are not both H). Some cpds. (I) are claimed per se, including 3-oxo-2-methyl-5,6-di-(4-methoxyphenyl)-1,2,4-triazine, to 3-thioanalogue and 3-hydroxy-5-(4-methoxyphenyl)-6-(2-chlorophenyl)-1,2,4-triazine. Used for treatment of severe pain for long periods because of low toxicity and side-effect incidence.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7632162A FR2368278A1 (en) | 1976-10-25 | 1976-10-25 | Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periods |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7632162A FR2368278A1 (en) | 1976-10-25 | 1976-10-25 | Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periods |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2368278A1 true FR2368278A1 (en) | 1978-05-19 |
FR2368278B1 FR2368278B1 (en) | 1980-09-19 |
Family
ID=9179183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7632162A Granted FR2368278A1 (en) | 1976-10-25 | 1976-10-25 | Analgesic 5,6-di:phenyl 1,2,4-triazine cpds. - used in treatment of acute pain over long periods |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2368278A1 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2391202A1 (en) * | 1977-05-17 | 1978-12-15 | Diamond Shamrock Corp | SUBSTITUTED, PHARMACOLOGICALLY ACTIVE TRIAZINES-1,2,4 AND MEDICINAL PRODUCTS CONTAINING THESE TRIAZINES |
FR2477873A1 (en) * | 1980-03-17 | 1981-09-18 | Fabre Sa Pierre | 5,6-Di:aryl 1,2,4-triazine cpds. used as solar filters - prepd. from di:aryl di:ketone(s) and semicarbazide cpds. |
FR2478095A1 (en) * | 1980-03-14 | 1981-09-18 | Fabre Sa Pierre | CETONIC DERIVATIVES OF DIARYL 5-6 1-2-4 ANTALGIC AND ANTIAGRANT TRIAZINES FOR THE TREATMENT OF MIGRAINE BACKGROUND |
FR2500830A1 (en) * | 1981-03-02 | 1982-09-03 | Fabre Sa Pierre | 2-Substd. 1,2,4-triazin-3-one(s) - having analgesic properties, prepd. by alkylating 2-unsubstituted triazinone |
EP0099438A1 (en) * | 1982-07-20 | 1984-02-01 | Pierre Fabre S.A. | 2-Functionalised diaryl as-triazines useful in therapy |
FR2544313A1 (en) * | 1983-04-14 | 1984-10-19 | Fabre Sa Pierre | N-CYCLOALCOYL METHYL-2-OXO-3-DIARYL 5-6 AS TRIAZINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS A MEDICINAL PRODUCT |
EP0194572A1 (en) * | 1985-03-12 | 1986-09-17 | Hoechst Aktiengesellschaft | Heterocyclic sulfides, process for their preparation and Medicaments containing them |
US4677105A (en) * | 1985-02-04 | 1987-06-30 | Pf Medicament | 2-alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-triazines having utility as therapeutics |
US5728698A (en) * | 1990-09-21 | 1998-03-17 | Rohm And Haas Company | Dihydropyridazinones, pyridazinones and related compounds as fungicides |
WO2008141013A1 (en) * | 2007-05-08 | 2008-11-20 | Allergan, Inc. | S1p3 receptor inhibitors for treating pain |
AU2006202334B2 (en) * | 2005-06-01 | 2010-01-21 | Schneider Electric New Zealand Holdings Limited | An Electric Fitting |
CN113134005A (en) * | 2020-01-16 | 2021-07-20 | 中国药科大学 | Application of TRPV1 channel targeting small molecule |
-
1976
- 1976-10-25 FR FR7632162A patent/FR2368278A1/en active Granted
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2391202A1 (en) * | 1977-05-17 | 1978-12-15 | Diamond Shamrock Corp | SUBSTITUTED, PHARMACOLOGICALLY ACTIVE TRIAZINES-1,2,4 AND MEDICINAL PRODUCTS CONTAINING THESE TRIAZINES |
FR2478095A1 (en) * | 1980-03-14 | 1981-09-18 | Fabre Sa Pierre | CETONIC DERIVATIVES OF DIARYL 5-6 1-2-4 ANTALGIC AND ANTIAGRANT TRIAZINES FOR THE TREATMENT OF MIGRAINE BACKGROUND |
EP0036357A1 (en) * | 1980-03-14 | 1981-09-23 | Pierre Fabre S.A. | Antalgic and antiagregant cetonic derivatives of 5,6-diaryl-1,2,4-triazines, usable in the treatment of migraine |
FR2477873A1 (en) * | 1980-03-17 | 1981-09-18 | Fabre Sa Pierre | 5,6-Di:aryl 1,2,4-triazine cpds. used as solar filters - prepd. from di:aryl di:ketone(s) and semicarbazide cpds. |
FR2500830A1 (en) * | 1981-03-02 | 1982-09-03 | Fabre Sa Pierre | 2-Substd. 1,2,4-triazin-3-one(s) - having analgesic properties, prepd. by alkylating 2-unsubstituted triazinone |
EP0099438A1 (en) * | 1982-07-20 | 1984-02-01 | Pierre Fabre S.A. | 2-Functionalised diaryl as-triazines useful in therapy |
US4511566A (en) * | 1983-04-14 | 1985-04-16 | Pierre Fabre S.A. | 2-N-Cycloalkylmethyl 3-oxo 5,6-diaryl-as-triazines |
EP0123605A1 (en) * | 1983-04-14 | 1984-10-31 | Pierre Fabre S.A. | N-Cyclopropylmethyl-2-oxo-3-diparamethoxyphenyl-5,6-triazines, process for its preparation and their use as pharmaceutical preparations |
FR2544313A1 (en) * | 1983-04-14 | 1984-10-19 | Fabre Sa Pierre | N-CYCLOALCOYL METHYL-2-OXO-3-DIARYL 5-6 AS TRIAZINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS A MEDICINAL PRODUCT |
US4677105A (en) * | 1985-02-04 | 1987-06-30 | Pf Medicament | 2-alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-triazines having utility as therapeutics |
EP0194572A1 (en) * | 1985-03-12 | 1986-09-17 | Hoechst Aktiengesellschaft | Heterocyclic sulfides, process for their preparation and Medicaments containing them |
US4762848A (en) * | 1985-03-12 | 1988-08-09 | Hoechst Aktiengesellschaft | 1,3-thiazoles and their use as immunomodulators |
US5728698A (en) * | 1990-09-21 | 1998-03-17 | Rohm And Haas Company | Dihydropyridazinones, pyridazinones and related compounds as fungicides |
AU2006202334B2 (en) * | 2005-06-01 | 2010-01-21 | Schneider Electric New Zealand Holdings Limited | An Electric Fitting |
WO2008141013A1 (en) * | 2007-05-08 | 2008-11-20 | Allergan, Inc. | S1p3 receptor inhibitors for treating pain |
CN113134005A (en) * | 2020-01-16 | 2021-07-20 | 中国药科大学 | Application of TRPV1 channel targeting small molecule |
Also Published As
Publication number | Publication date |
---|---|
FR2368278B1 (en) | 1980-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |