FR2363327A1 - Bicyclic-substd. amino-alcohols and their esters - for treatment of hypertension and cardiovascular disorders - Google Patents

Bicyclic-substd. amino-alcohols and their esters - for treatment of hypertension and cardiovascular disorders

Info

Publication number
FR2363327A1
FR2363327A1 FR7626281A FR7626281A FR2363327A1 FR 2363327 A1 FR2363327 A1 FR 2363327A1 FR 7626281 A FR7626281 A FR 7626281A FR 7626281 A FR7626281 A FR 7626281A FR 2363327 A1 FR2363327 A1 FR 2363327A1
Authority
FR
France
Prior art keywords
substd
alkyl
phenyl
alkanoyl
bicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7626281A
Other languages
French (fr)
Other versions
FR2363327B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Continental Pharma Inc
Original Assignee
Continental Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma Inc filed Critical Continental Pharma Inc
Priority to FR7626281A priority Critical patent/FR2363327A1/en
Priority to NO763917A priority patent/NO147748C/en
Priority to OA56080A priority patent/OA05578A/en
Publication of FR2363327A1 publication Critical patent/FR2363327A1/en
Application granted granted Critical
Publication of FR2363327B1 publication Critical patent/FR2363327B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. of formula (I) and their salts are new R1 is H, phenyl, CO2H or one or two 1-3C alkyl groups; R2 is 1-3C alkyl; R3 is 3-18C alkenyl (one or more double bonds); 3-12C alkenyl (one or more double bonds) substd. by O, S or phenyl; 3-18C alkynyl (one or more triple bonds); 3-12C alkynyl (one or more triple bonds) substd. by O, S or phenyl; 3-10C cycloalkyl; 2-20C alkyl; 2-18C alkyl substd. by one or more O, S, 1-3C alkoxycarbonyl, pyrrolidine, pyrrolidinone, imidazolidone, phenyl, phenoxy, phenylthio, benzoyl, indanyloxy, naphthyloxy, or substd. by phenyl, phenoxy, phenylthio, or benzoyl themselves substd. by one or two halo or 1-4C alkyl or alkoxy or by a CN, OH, NH2, 2-6C alkanoyl, 2-4C acylamino, 1-4C alkoxycarbonyl or 1-4C alkylsulphonamido; R4 is H; or R4 + R3 and the attached N-atom form a morpholine, pyrrolidine, piperidine; piperidine substd. by one or two 1-4C alkyl, phenyl or phenyl-(1-4C alkyl); piperazine substd. in 4-position by phenyl opt. substd. by one or two 1-4C alkyl, 1-4C alkoxy or halo, or by a CF3 group; R5 is H or 1-3C alkyl; R6 is H, 1-10C alkanoyl or 3-8C cycloalkanoyl; n is 1,2 or 3; X is S, O, -CH2- or -NH-; Y is -CH2- or S; provided that when, simultaneously X is O; Y is -CH2-; n is 2; R1 and R5 are H; R2 is Me; and R6 is H or alkanoyl, R4 + R3 and the attached N atom do not form a substd. piperazine gp.
FR7626281A 1975-11-18 1976-08-31 Bicyclic-substd. amino-alcohols and their esters - for treatment of hypertension and cardiovascular disorders Granted FR2363327A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR7626281A FR2363327A1 (en) 1976-08-31 1976-08-31 Bicyclic-substd. amino-alcohols and their esters - for treatment of hypertension and cardiovascular disorders
NO763917A NO147748C (en) 1975-11-18 1976-11-17 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE AMINOAL ALCOHOL DERIVATIVES
OA56080A OA05578A (en) 1976-08-31 1977-02-19 Amino-alcohol derivatives, pharmaceutical composition based on these derivatives as well as their preparation process and their use.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7626281A FR2363327A1 (en) 1976-08-31 1976-08-31 Bicyclic-substd. amino-alcohols and their esters - for treatment of hypertension and cardiovascular disorders

Publications (2)

Publication Number Publication Date
FR2363327A1 true FR2363327A1 (en) 1978-03-31
FR2363327B1 FR2363327B1 (en) 1979-01-12

Family

ID=9177282

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7626281A Granted FR2363327A1 (en) 1975-11-18 1976-08-31 Bicyclic-substd. amino-alcohols and their esters - for treatment of hypertension and cardiovascular disorders

Country Status (1)

Country Link
FR (1) FR2363327A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000825A1 (en) * 1977-08-05 1979-02-21 Kabi AB Geminally disubstituted indene derivatives, processes for their preparation and pharmaceutical compositions containing them

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2138488A1 (en) * 1971-05-27 1973-01-05 Lipha 1-(5-indanyl)-omega-aminoalkanes - with tranquillizing activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2138488A1 (en) * 1971-05-27 1973-01-05 Lipha 1-(5-indanyl)-omega-aminoalkanes - with tranquillizing activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000825A1 (en) * 1977-08-05 1979-02-21 Kabi AB Geminally disubstituted indene derivatives, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2363327B1 (en) 1979-01-12

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse