FR2357564A1 - PROCESS FOR THE PREPARATION OF (L'3) D-LACTONE FROM 5B-HALOGENO-2B-HYDROXYMETHYLCYCLOPENTANE-3A-HYDROXY-1A-ACETIC RACEMIC OR OPTICALLY ACTIVE - Google Patents

PROCESS FOR THE PREPARATION OF (L'3) D-LACTONE FROM 5B-HALOGENO-2B-HYDROXYMETHYLCYCLOPENTANE-3A-HYDROXY-1A-ACETIC RACEMIC OR OPTICALLY ACTIVE

Info

Publication number
FR2357564A1
FR2357564A1 FR7702912A FR7702912A FR2357564A1 FR 2357564 A1 FR2357564 A1 FR 2357564A1 FR 7702912 A FR7702912 A FR 7702912A FR 7702912 A FR7702912 A FR 7702912A FR 2357564 A1 FR2357564 A1 FR 2357564A1
Authority
FR
France
Prior art keywords
hydroxymethylcyclopentane
halogeno
lactone
hydroxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7702912A
Other languages
French (fr)
Other versions
FR2357564B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlo Erba SpA filed Critical Carlo Erba SpA
Publication of FR2357564A1 publication Critical patent/FR2357564A1/en
Application granted granted Critical
Publication of FR2357564B1 publication Critical patent/FR2357564B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

L'invention concerne un procédé pour la préparation d'une (1' --> 3) delta -lactone d'acide 5 beta -halogéno-2 beta -hydroxyméthylcyclopentane-3 alpha -hydroxy-1 alpha -acétique de formule générale I, dans laquelle X est un atome de chlore ou de brome Le procédé selon l'invention comprend les étapes suivantes : a. acétalisation d'un composé de formule générale Il, dans laquelle X est le chlore ou le brome et Y est un groupe carboxy ou un de ses dérivés fonctionnels, pour donner un composé de formule III, dans laquelle X et Y sont tels queThe invention relates to a process for the preparation of a (1 '-> 3) delta -lactone of 5 beta -halogeno-2 beta -hydroxymethylcyclopentane-3 alpha -hydroxy-1 alpha -acetic acid of general formula I, in which X is a chlorine or bromine atom. The process according to the invention comprises the following steps: a. acetalization of a compound of general formula II, in which X is chlorine or bromine and Y is a carboxy group or a functional derivative thereof, to give a compound of formula III, in which X and Y are such that

FR7702912A 1976-02-03 1977-02-02 PROCESS FOR THE PREPARATION OF (L'3) D-LACTONE FROM 5B-HALOGENO-2B-HYDROXYMETHYLCYCLOPENTANE-3A-HYDROXY-1A-ACETIC RACEMIC OR OPTICALLY ACTIVE Granted FR2357564A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1982376A IT1063095B (en) 1976-02-03 1976-02-03 RESOLUTION OF 6 ALO BICYCLE 2.Z.I. EPTAN 3 ONE 3.3 ETHYLENDIOXIS 7 ACID CARBOSYLIC AND SYNTHESIS OF 5 BETA ALO 2 BETA HYDROXYMETHYL CYCLOPENTAN 3 ALPHA HYDROXY I ALPHA ACETIC ACID 1.3 DELTA LATTONE

Publications (2)

Publication Number Publication Date
FR2357564A1 true FR2357564A1 (en) 1978-02-03
FR2357564B1 FR2357564B1 (en) 1981-10-30

Family

ID=11161574

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7702912A Granted FR2357564A1 (en) 1976-02-03 1977-02-02 PROCESS FOR THE PREPARATION OF (L'3) D-LACTONE FROM 5B-HALOGENO-2B-HYDROXYMETHYLCYCLOPENTANE-3A-HYDROXY-1A-ACETIC RACEMIC OR OPTICALLY ACTIVE
FR7718526A Granted FR2346347A1 (en) 1976-02-03 1977-06-16 METHOD OF OPTICAL RESOLUTION OF A DIACETAL OF A 6-HALOGENOBICYCLO (2.2.1) HEPTANE-3-ONE-7-CARBOXYLIC ACID

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7718526A Granted FR2346347A1 (en) 1976-02-03 1977-06-16 METHOD OF OPTICAL RESOLUTION OF A DIACETAL OF A 6-HALOGENOBICYCLO (2.2.1) HEPTANE-3-ONE-7-CARBOXYLIC ACID

Country Status (6)

Country Link
JP (1) JPS5295671A (en)
DE (1) DE2702807A1 (en)
FR (2) FR2357564A1 (en)
GB (2) GB1533207A (en)
IT (1) IT1063095B (en)
SE (1) SE431209B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3242433A1 (en) * 1982-11-16 1984-05-17 Vysoká škola chemicko-technologická Praha, Praha Process for the preparation of hexahydro-5-hydroxy- 4-hydroxymethyl-2H-cyclopenta[b]furan-2-one derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7413915A (en) * 1973-10-24 1975-04-28 Pfizer PROCESS FOR PREPARING NEW ORGANIC COMPOUNDS.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7413915A (en) * 1973-10-24 1975-04-28 Pfizer PROCESS FOR PREPARING NEW ORGANIC COMPOUNDS.

Also Published As

Publication number Publication date
SE7701019L (en) 1977-08-04
FR2346347B1 (en) 1981-10-02
IT1063095B (en) 1985-02-11
JPS6133029B2 (en) 1986-07-31
FR2346347A1 (en) 1977-10-28
GB1533208A (en) 1978-11-22
SE431209B (en) 1984-01-23
GB1533207A (en) 1978-11-22
FR2357564B1 (en) 1981-10-30
DE2702807A1 (en) 1977-08-04
JPS5295671A (en) 1977-08-11

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