FR2343483A1 - L'ester methylique de la 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-isoglutamine et le diester methylique de l'acide 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-glutamique et medicaments les contenant - Google Patents

L'ester methylique de la 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-isoglutamine et le diester methylique de l'acide 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-glutamique et medicaments les contenant

Info

Publication number
FR2343483A1
FR2343483A1 FR7606820A FR7606820A FR2343483A1 FR 2343483 A1 FR2343483 A1 FR 2343483A1 FR 7606820 A FR7606820 A FR 7606820A FR 7606820 A FR7606820 A FR 7606820A FR 2343483 A1 FR2343483 A1 FR 2343483A1
Authority
FR
France
Prior art keywords
glucopyranosyl
alanyl
acetamido
deoxy
propionyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7606820A
Other languages
English (en)
French (fr)
Other versions
FR2343483B1 (cg-RX-API-DMAC10.html
Inventor
Francoise Audibert
Louis Chedid
Pierre Lefrancier
Jean Choay
Egar Lederer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR7606820A priority Critical patent/FR2343483A1/fr
Priority to US05/775,215 priority patent/US4153684A/en
Priority to CA273,417A priority patent/CA1098515A/en
Priority to AU22992/77A priority patent/AU516843B2/en
Priority to JP2552977A priority patent/JPS52139018A/ja
Priority to BE175701A priority patent/BE852349A/xx
Priority to DE2710454A priority patent/DE2710454C2/de
Priority to CH305277A priority patent/CH619469A5/fr
Priority to DK105477A priority patent/DK151813C/da
Priority to GB10110/77A priority patent/GB1573126A/en
Priority to NL7702579A priority patent/NL7702579A/xx
Publication of FR2343483A1 publication Critical patent/FR2343483A1/fr
Application granted granted Critical
Publication of FR2343483B1 publication Critical patent/FR2343483B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
FR7606820A 1976-03-10 1976-03-10 L'ester methylique de la 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-isoglutamine et le diester methylique de l'acide 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-glutamique et medicaments les contenant Granted FR2343483A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR7606820A FR2343483A1 (fr) 1976-03-10 1976-03-10 L'ester methylique de la 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-isoglutamine et le diester methylique de l'acide 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-glutamique et medicaments les contenant
US05/775,215 US4153684A (en) 1976-03-10 1977-03-07 Immunizing and anti-infectious adjuvant agents constituted by N-acetyl-muramyl-L-alanyl-D-glutamic acid derivatives
AU22992/77A AU516843B2 (en) 1976-03-10 1977-03-08 Anti-infectious agent and -methyl esters
CA273,417A CA1098515A (en) 1976-03-10 1977-03-08 Immunising and anti-infectious adjuvant agents constituted by esters of the n-acetyl-muramyl-l- alanyl-d-isoglutamine
BE175701A BE852349A (fr) 1976-03-10 1977-03-10 Agents adjuvants immunitaires et anti-infectieux
DE2710454A DE2710454C2 (de) 1976-03-10 1977-03-10 Ester von N-Acetylmuramyl-L-alanyl-D-isoglutamin sowie Mono- und Diester von N-Acetylmuramyl-L-alanyl-D-glutaminsäure, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
JP2552977A JPS52139018A (en) 1976-03-10 1977-03-10 Immuno adjuvant and antiinfection adjuvant composed of mainly nnacetyll muramiccllalanyllddglutamic ester or nnacetyllmuramiccllalanylldd isoglutamic ester
CH305277A CH619469A5 (en) 1976-03-10 1977-03-10 Process for the preparation of the esters of N-acetyl-muramyl-L-alanyl-D-glutamic acid and of N-acetyl-muramyl-L-alanyl-D-isoglutamine
DK105477A DK151813C (da) 1976-03-10 1977-03-10 Analogifremgangsmaade til fremstilling af estere af n-acetyl-muramyl-l-alanyl-d-glutaminsyre og af n-acetyl-muramyl-l-alanyl-d-isoglutamin
GB10110/77A GB1573126A (en) 1976-03-10 1977-03-10 Immunising and anti-infectious adjuvant agents comprising peptide derivatives of muramic acid
NL7702579A NL7702579A (nl) 1976-03-10 1977-03-10 Werkwijze ter bereiding van immuniserende en anti- infectieuze middelen.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7606820A FR2343483A1 (fr) 1976-03-10 1976-03-10 L'ester methylique de la 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-isoglutamine et le diester methylique de l'acide 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-glutamique et medicaments les contenant

Publications (2)

Publication Number Publication Date
FR2343483A1 true FR2343483A1 (fr) 1977-10-07
FR2343483B1 FR2343483B1 (cg-RX-API-DMAC10.html) 1979-06-29

Family

ID=9170213

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7606820A Granted FR2343483A1 (fr) 1976-03-10 1976-03-10 L'ester methylique de la 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-isoglutamine et le diester methylique de l'acide 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d-glutamique et medicaments les contenant

Country Status (4)

Country Link
AU (1) AU516843B2 (cg-RX-API-DMAC10.html)
BE (1) BE852349A (cg-RX-API-DMAC10.html)
CA (1) CA1098515A (cg-RX-API-DMAC10.html)
FR (1) FR2343483A1 (cg-RX-API-DMAC10.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2533827A1 (fr) * 1982-09-30 1984-04-06 Anvar Composition possedant des proprietes immunoregulatrices, notamment d'adjuvants immunologiques non specifiques, a base de muramylpeptide et d'un derive d'aluminium
US4652449A (en) * 1982-07-05 1987-03-24 Centre National De La Recherche Scientifique (Cnrs) Encapsulating biological active substances into erythrocytes
WO1996031533A1 (fr) * 1995-04-07 1996-10-10 Vacsyn S.A. Derives et conjugues du mdp presentant une activite stimulatrice de la fonction hematopoietique et composition les contenant

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2428050A1 (fr) * 1978-06-05 1980-01-04 Anvar Oligomeres de composes du type muramyl-peptide et medicaments les contenant
US4256735A (en) 1979-01-29 1981-03-17 Merck & Co., Inc. Immunologically active dipeptidyl saccharides and methods of preparation
US4391800A (en) 1979-04-27 1983-07-05 Merck & Co., Inc. Immunologically active peptidyl disaccharides and methods of preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH83A (fr) * 1888-11-17 1889-01-10 Fontainemelon Horlogerie Perfectionnements apportés à la construction des montres de tous calibres

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH83A (fr) * 1888-11-17 1889-01-10 Fontainemelon Horlogerie Perfectionnements apportés à la construction des montres de tous calibres

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1975 161 981Z CITE BIKEN J., 1975, 18, 105-111 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652449A (en) * 1982-07-05 1987-03-24 Centre National De La Recherche Scientifique (Cnrs) Encapsulating biological active substances into erythrocytes
US4752586A (en) * 1982-07-05 1988-06-21 Centre National De La Recherche Scientifique Apparatus for encapsulating biological active substances into erythrocytes
FR2533827A1 (fr) * 1982-09-30 1984-04-06 Anvar Composition possedant des proprietes immunoregulatrices, notamment d'adjuvants immunologiques non specifiques, a base de muramylpeptide et d'un derive d'aluminium
WO1996031533A1 (fr) * 1995-04-07 1996-10-10 Vacsyn S.A. Derives et conjugues du mdp presentant une activite stimulatrice de la fonction hematopoietique et composition les contenant
FR2732604A1 (fr) * 1995-04-07 1996-10-11 Vacsyn Sa Derives et conjugues du mdp presentant une activite stimulatrice de la fonction hematopoietique et compositions les contenant

Also Published As

Publication number Publication date
BE852349A (fr) 1977-09-12
AU2299277A (en) 1978-09-14
CA1098515A (en) 1981-03-31
FR2343483B1 (cg-RX-API-DMAC10.html) 1979-06-29
AU516843B2 (en) 1981-06-25

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