FR2335207A1 - Derives de n-oxyde de 9,10-dihydro-9,10-methanoanthracene et leur utilisation, notamment comme tranquillisants et comme agents anti-epilepsie - Google Patents

Derives de n-oxyde de 9,10-dihydro-9,10-methanoanthracene et leur utilisation, notamment comme tranquillisants et comme agents anti-epilepsie

Info

Publication number
FR2335207A1
FR2335207A1 FR7637505A FR7637505A FR2335207A1 FR 2335207 A1 FR2335207 A1 FR 2335207A1 FR 7637505 A FR7637505 A FR 7637505A FR 7637505 A FR7637505 A FR 7637505A FR 2335207 A1 FR2335207 A1 FR 2335207A1
Authority
FR
France
Prior art keywords
methanoanthracene
tranquilizers
dihydro
oxide derivatives
epilepsy agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7637505A
Other languages
English (en)
French (fr)
Other versions
FR2335207B1 (cg-RX-API-DMAC10.html
Inventor
Hiroshi Tanida
Tadashi Irie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of FR2335207A1 publication Critical patent/FR2335207A1/fr
Application granted granted Critical
Publication of FR2335207B1 publication Critical patent/FR2335207B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7637505A 1975-12-15 1976-12-13 Derives de n-oxyde de 9,10-dihydro-9,10-methanoanthracene et leur utilisation, notamment comme tranquillisants et comme agents anti-epilepsie Granted FR2335207A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB51318/75A GB1531278A (en) 1975-12-15 1975-12-15 9,10-dihydro-9,10-methanoanthracene n-oxide derivatives and the production thereof

Publications (2)

Publication Number Publication Date
FR2335207A1 true FR2335207A1 (fr) 1977-07-15
FR2335207B1 FR2335207B1 (cg-RX-API-DMAC10.html) 1979-06-22

Family

ID=10459524

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7637505A Granted FR2335207A1 (fr) 1975-12-15 1976-12-13 Derives de n-oxyde de 9,10-dihydro-9,10-methanoanthracene et leur utilisation, notamment comme tranquillisants et comme agents anti-epilepsie

Country Status (8)

Country Link
US (2) US4153629A (cg-RX-API-DMAC10.html)
JP (1) JPS6054302B2 (cg-RX-API-DMAC10.html)
AU (1) AU504589B2 (cg-RX-API-DMAC10.html)
CA (1) CA1079282A (cg-RX-API-DMAC10.html)
DE (1) DE2656078A1 (cg-RX-API-DMAC10.html)
FR (1) FR2335207A1 (cg-RX-API-DMAC10.html)
GB (1) GB1531278A (cg-RX-API-DMAC10.html)
NL (1) NL7613937A (cg-RX-API-DMAC10.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1531278A (en) * 1975-12-15 1978-11-08 Shionogi & Co 9,10-dihydro-9,10-methanoanthracene n-oxide derivatives and the production thereof
CA2014201A1 (en) * 1989-04-26 1990-10-26 Albemarle Corporation Solid non-hygroscopic trialkylamine oxides
KR960008230B1 (ko) * 1989-10-17 1996-06-21 윌리엄 쥐.씨먼 중추신경계의 산화적 손상에 관련된 질병들을 억제하기 위한 조성물들
US20050107366A1 (en) * 1991-06-18 2005-05-19 Carney John M. Spin trapping pharmaceutical compositions and methods for use thereof
US6002001A (en) * 1991-06-18 1999-12-14 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
US5512575A (en) * 1991-08-15 1996-04-30 Zeneca Limited Methanoanthraceneyl methyl piperidinyl compounds
GB9216297D0 (en) * 1991-08-15 1992-09-16 Ici Plc Therapeutic agents
GB9117639D0 (en) * 1991-08-15 1991-10-02 Ici Plc Therapeutic compounds
GB9216298D0 (en) * 1991-08-15 1992-09-16 Ici Plc Piperidine derivatives
US6693064B2 (en) 1996-04-16 2004-02-17 Unichema Chemie B.V. Hydraulic fluids
US5900227A (en) * 1996-06-17 1999-05-04 Oklahoma Medical Research Foundation Multicyclic nitrone spin trapping compositions
KR20080065704A (ko) 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB618034A (en) * 1946-10-16 1949-02-15 Geigy Ag J R Manufacture of basically substituted 9:10-dihydroanthracene derivatives, and their salts and amino-oxides
NL127069C (cg-RX-API-DMAC10.html) * 1961-10-10
GB991651A (en) * 1963-02-20 1965-05-12 Dumex Ltd As Dibenzocycloheptadiene derivatives
US3579582A (en) * 1967-02-16 1971-05-18 Universal Oil Prod Co Hydroxy and/or hydrocarbyloxy and amino substituted tetrahydronaphthalenes
US3493616A (en) * 1967-02-27 1970-02-03 Universal Oil Prod Co Hydroxy and/or hydrocarbyloxy and amino-alkano-tetrahydronaphthalenes
US3952017A (en) * 1968-05-03 1976-04-20 Hoffmann-La Roche Inc. Tricyclic compounds
US3622630A (en) * 1968-07-03 1971-11-23 Smith Kline French Lab 10-aminoalkyl-9,10-dihydroanthracenes
GB1531278A (en) * 1975-12-15 1978-11-08 Shionogi & Co 9,10-dihydro-9,10-methanoanthracene n-oxide derivatives and the production thereof

Also Published As

Publication number Publication date
CA1079282A (en) 1980-06-10
JPS6054302B2 (ja) 1985-11-29
JPS5273853A (en) 1977-06-21
US4216231A (en) 1980-08-05
AU2059376A (en) 1978-06-22
GB1531278A (en) 1978-11-08
FR2335207B1 (cg-RX-API-DMAC10.html) 1979-06-22
AU504589B2 (en) 1979-10-18
NL7613937A (nl) 1977-06-17
US4153629A (en) 1979-05-08
DE2656078A1 (de) 1977-06-23

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Legal Events

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ST Notification of lapse