FR2334355A2 - Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876) - Google Patents

Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876)

Info

Publication number
FR2334355A2
FR2334355A2 FR7538063A FR7538063A FR2334355A2 FR 2334355 A2 FR2334355 A2 FR 2334355A2 FR 7538063 A FR7538063 A FR 7538063A FR 7538063 A FR7538063 A FR 7538063A FR 2334355 A2 FR2334355 A2 FR 2334355A2
Authority
FR
France
Prior art keywords
thiazolyl
alkyl
derivs
isocyantaates
carbmate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7538063A
Other languages
French (fr)
Other versions
FR2334355B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7538063A priority Critical patent/FR2334355A2/en
Priority to AR262223A priority patent/AR208020A1/en
Priority to US05/654,630 priority patent/US4032643A/en
Priority to IL48970A priority patent/IL48970A/en
Priority to HU76RO00000876A priority patent/HU171952B/en
Priority to AT99576A priority patent/AT350557B/en
Priority to LU74340A priority patent/LU74340A1/xx
Priority to DD191211A priority patent/DD124980A5/xx
Priority to SE7601591A priority patent/SE7601591L/en
Priority to BE164264A priority patent/BE838490A/en
Priority to PT64803A priority patent/PT64803B/en
Priority to DE19762605840 priority patent/DE2605840A1/en
Priority to GB5820/76A priority patent/GB1535267A/en
Priority to IE295/76A priority patent/IE42775B1/en
Priority to ES445150A priority patent/ES445150A1/en
Priority to AU11107/76A priority patent/AU498500B2/en
Priority to CH180976A priority patent/CH610314A5/xx
Priority to DK58676*#A priority patent/DK58676A/en
Priority to JP51014120A priority patent/JPS51105058A/ja
Priority to NL7601563A priority patent/NL7601563A/en
Publication of FR2334355A2 publication Critical patent/FR2334355A2/en
Application granted granted Critical
Publication of FR2334355B2 publication Critical patent/FR2334355B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Carbamate derivs. of formula (I) (where R1 is 1-5C alkyl; R2 is NH2, 1-4C alkylamino, di(1-4C alkyl) amino, anilino or diphenylamino; and n is 1-6), e.g. 2-methyl-5-(N-methylcarbamoyloxymethyl)thiazole, and their addition salts with mineral acids or organic sulphonic acids are new cpds. (I) have antiliopolytic properties, reducing plasma free fatty acid levels Certain cpds. (I) have peripheral vasodilatory and anti-bradykinin activity. (I) are useful for the treatment of acute or chronic hyperlipaemia, coronary insufficiency or atheromatous origin, chronic angina and functional hypertensive disorders.
FR7538063A 1975-02-14 1975-12-12 Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876) Granted FR2334355A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR7538063A FR2334355A2 (en) 1975-12-12 1975-12-12 Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876)
AR262223A AR208020A1 (en) 1975-02-14 1976-01-01 PROCEDURE FOR THE PREPARATION OF 2-ALKYL-5 - ((N-SUBSTITUTED CARBAMOYLOXY) ALKYL) -THAZOLE
US05/654,630 US4032643A (en) 1975-02-14 1976-02-02 Novel thiazole derivatives
IL48970A IL48970A (en) 1975-02-14 1976-02-04 2alkyl-5-thiazolylakyl carbamates, process for preparing them and pharmaceutical compositions containing them
HU76RO00000876A HU171952B (en) 1975-02-14 1976-02-05 Process for producing thiazole derivatives
LU74340A LU74340A1 (en) 1975-02-14 1976-02-12
DD191211A DD124980A5 (en) 1975-02-14 1976-02-12
SE7601591A SE7601591L (en) 1975-02-14 1976-02-12 WAY TO PRODUCE NEW TIAZOLE DERIVATIVES
BE164264A BE838490A (en) 1975-02-14 1976-02-12 NEW THIAZOLIC DERIVATIVES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION
AT99576A AT350557B (en) 1975-02-14 1976-02-12 PROCESS FOR PRODUCING NEW THIAZOLE DERIVATIVES AND THEIR SALTS
PT64803A PT64803B (en) 1975-02-14 1976-02-13 PROCESS FOR THE PREPARATION OF NEW THIAZOLIC DERIVATIVES
GB5820/76A GB1535267A (en) 1975-02-14 1976-02-13 Thiazole derivatives
IE295/76A IE42775B1 (en) 1975-02-14 1976-02-13 Thiazole derivatives
ES445150A ES445150A1 (en) 1975-02-14 1976-02-13 Novel thiazole derivatives
AU11107/76A AU498500B2 (en) 1975-02-14 1976-02-13 Thiazoles
CH180976A CH610314A5 (en) 1975-02-14 1976-02-13
DE19762605840 DE2605840A1 (en) 1975-02-14 1976-02-13 NEW THIAZOLE DERIVATIVES, PROCEDURES FOR THEIR MANUFACTURING AND PHARMACEUTICAL COMPOSITIONS
JP51014120A JPS51105058A (en) 1975-02-14 1976-02-13
DK58676*#A DK58676A (en) 1975-02-14 1976-02-13 PROCEDURE FOR THE PREPARATION OF THIAZOLE DERIVATIVES
NL7601563A NL7601563A (en) 1975-02-14 1976-02-16 PROCESS FOR PREPARING NEW THIAZOLE COMPOUNDS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7538063A FR2334355A2 (en) 1975-12-12 1975-12-12 Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876)

Publications (2)

Publication Number Publication Date
FR2334355A2 true FR2334355A2 (en) 1977-07-08
FR2334355B2 FR2334355B2 (en) 1978-08-25

Family

ID=9163664

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7538063A Granted FR2334355A2 (en) 1975-02-14 1975-12-12 Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876)

Country Status (1)

Country Link
FR (1) FR2334355A2 (en)

Also Published As

Publication number Publication date
FR2334355B2 (en) 1978-08-25

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