FR2323378A1 - Nouvelles amidines ayant des proprietes antiarythmiques - Google Patents
Nouvelles amidines ayant des proprietes antiarythmiquesInfo
- Publication number
- FR2323378A1 FR2323378A1 FR7527638A FR7527638A FR2323378A1 FR 2323378 A1 FR2323378 A1 FR 2323378A1 FR 7527638 A FR7527638 A FR 7527638A FR 7527638 A FR7527638 A FR 7527638A FR 2323378 A1 FR2323378 A1 FR 2323378A1
- Authority
- FR
- France
- Prior art keywords
- benzamidine
- prepd
- benzamidines
- antiarrhythmic
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 dialkyl amino alkyl benzamidines Chemical class 0.000 title abstract 3
- 125000005263 alkylenediamine group Chemical group 0.000 title 1
- 230000003288 anthiarrhythmic effect Effects 0.000 title 1
- 239000003416 antiarrhythmic agent Substances 0.000 title 1
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- VFXZSOGEOVNLFF-UHFFFAOYSA-N N'-[2-(diethylamino)ethyl]-4-nitrobenzenecarboximidamide dihydrochloride Chemical compound Cl.Cl.[N+](=O)([O-])C1=CC=C(C(=N)NCCN(CC)CC)C=C1 VFXZSOGEOVNLFF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 229940124326 anaesthetic agent Drugs 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- CJXJAUKCHHAJQN-UHFFFAOYSA-N hydron;4-nitrobenzenecarboximidamide;chloride Chemical compound Cl.NC(=N)C1=CC=C([N+]([O-])=O)C=C1 CJXJAUKCHHAJQN-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- UDGSVBYJWHOHNN-UHFFFAOYSA-N n',n'-diethylethane-1,2-diamine Chemical compound CCN(CC)CCN UDGSVBYJWHOHNN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 abstract 1
- 229960000244 procainamide Drugs 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 231100001274 therapeutic index Toxicity 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7527638A FR2323378A1 (fr) | 1975-09-09 | 1975-09-09 | Nouvelles amidines ayant des proprietes antiarythmiques |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7527638A FR2323378A1 (fr) | 1975-09-09 | 1975-09-09 | Nouvelles amidines ayant des proprietes antiarythmiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2323378A1 true FR2323378A1 (fr) | 1977-04-08 |
| FR2323378B1 FR2323378B1 (OSRAM) | 1979-09-14 |
Family
ID=9159774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7527638A Granted FR2323378A1 (fr) | 1975-09-09 | 1975-09-09 | Nouvelles amidines ayant des proprietes antiarythmiques |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2323378A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0093443A1 (de) * | 1982-05-05 | 1983-11-09 | Hoechst Aktiengesellschaft | 4-Halomethylbenzoesäure-alkylester-imine und Verfahren zu deren Herstellung |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1576553A (OSRAM) * | 1967-05-30 | 1969-08-01 |
-
1975
- 1975-09-09 FR FR7527638A patent/FR2323378A1/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1576553A (OSRAM) * | 1967-05-30 | 1969-08-01 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0093443A1 (de) * | 1982-05-05 | 1983-11-09 | Hoechst Aktiengesellschaft | 4-Halomethylbenzoesäure-alkylester-imine und Verfahren zu deren Herstellung |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2323378B1 (OSRAM) | 1979-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |