FR2320752A1 - (4)-Hydroxy-(3)-nitro-pyrido(2,3b)-pyridinones - antiallergics, antihistamines used for asthma prepd. from nitroacetate, base and a pyrido(2,3d)oxazinedione - Google Patents

(4)-Hydroxy-(3)-nitro-pyrido(2,3b)-pyridinones - antiallergics, antihistamines used for asthma prepd. from nitroacetate, base and a pyrido(2,3d)oxazinedione

Info

Publication number
FR2320752A1
FR2320752A1 FR7624661A FR7624661A FR2320752A1 FR 2320752 A1 FR2320752 A1 FR 2320752A1 FR 7624661 A FR7624661 A FR 7624661A FR 7624661 A FR7624661 A FR 7624661A FR 2320752 A1 FR2320752 A1 FR 2320752A1
Authority
FR
France
Prior art keywords
pyrido
alkyl
nitroacetate
prepd
asthma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7624661A
Other languages
French (fr)
Other versions
FR2320752B1 (en
Inventor
Goetz Eduard Hardtmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2320752A1 publication Critical patent/FR2320752A1/en
Application granted granted Critical
Publication of FR2320752B1 publication Critical patent/FR2320752B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Pyrido (2,3-b) pyridines of formula (I) and their salts are novel. In (I) R is H, 1-6C alkyl, 3-6C alkenyl or alkynyl in which the multiple bond is not in the alpha position with respect to the N atom, 3-6C cycloalkyl, 3-6C cycloalkyl-1-2C alkyl or Y, Y1 are each H, F, Cl, Br, 1-3C alkyl, 1-3C alkoxy or CF3; n = 0 or 1; R1, R2 are each H or 1-4C alkyl. With the condition that at least one of R, R1, R2 is not H). (I) have activity similar to that of disodium chromoglycate in particular inhibiting the liberation of histamine. They are used to treat allergic states e.g. allergic asthma by administration in daily doses of 20-200 mg by oral, parenteral or rectal routes. (I) are prepd. by reacting nitroacetate with strong base and pyrido (2,3-d) oxazine-2,4-dione. Pref. cpds. are R1=7-methyl, R2=H and R=methyl or allyl.
FR7624661A 1975-08-15 1976-08-12 (4)-Hydroxy-(3)-nitro-pyrido(2,3b)-pyridinones - antiallergics, antihistamines used for asthma prepd. from nitroacetate, base and a pyrido(2,3d)oxazinedione Granted FR2320752A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60515275A 1975-08-15 1975-08-15

Publications (2)

Publication Number Publication Date
FR2320752A1 true FR2320752A1 (en) 1977-03-11
FR2320752B1 FR2320752B1 (en) 1978-11-17

Family

ID=24422480

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7624661A Granted FR2320752A1 (en) 1975-08-15 1976-08-12 (4)-Hydroxy-(3)-nitro-pyrido(2,3b)-pyridinones - antiallergics, antihistamines used for asthma prepd. from nitroacetate, base and a pyrido(2,3d)oxazinedione

Country Status (14)

Country Link
JP (1) JPS5236694A (en)
AU (1) AU1684576A (en)
BE (1) BE845196A (en)
DE (1) DE2635216A1 (en)
DK (1) DK357676A (en)
FI (1) FI762259A (en)
FR (1) FR2320752A1 (en)
IL (1) IL50262A0 (en)
NL (1) NL7608906A (en)
NO (1) NO762736L (en)
NZ (1) NZ181763A (en)
PT (1) PT65478B (en)
SE (1) SE7608838L (en)
ZA (1) ZA764882B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2913977A1 (en) * 2007-03-21 2008-09-26 Centre Nat Rech Scient TRANSANNUAL REARRANGEMENT OF ACTIVE LACTAMS

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452800A (en) * 1982-04-26 1984-06-05 Schering Corporation Salts of 3(n-butyl)-4-hydroxy-1-phenyl-1,8-naphthyridine-2(1H)-one and their use in treating chronic obstructive lung diseases
JP2988739B2 (en) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 1,8-naphthyridin-2-one derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY, 18, 726-32 1975 ) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2913977A1 (en) * 2007-03-21 2008-09-26 Centre Nat Rech Scient TRANSANNUAL REARRANGEMENT OF ACTIVE LACTAMS
WO2008125421A1 (en) * 2007-03-21 2008-10-23 Centre National De La Recherche Scientifique (Cnrs) Trans-annular rearrangement of active lactames
US8592587B2 (en) 2007-03-21 2013-11-26 Centre National De La Recherche Scientifique (Cnrs) Transannular rearrangement of activated lactams

Also Published As

Publication number Publication date
PT65478A (en) 1976-09-01
JPS5236694A (en) 1977-03-22
ZA764882B (en) 1978-03-29
PT65478B (en) 1978-05-10
NZ181763A (en) 1978-07-10
FI762259A (en) 1977-02-16
IL50262A0 (en) 1976-10-31
NL7608906A (en) 1977-02-17
BE845196A (en) 1977-02-14
SE7608838L (en) 1977-02-16
DE2635216A1 (en) 1977-03-03
FR2320752B1 (en) 1978-11-17
DK357676A (en) 1977-02-16
NO762736L (en) 1977-02-16
AU1684576A (en) 1978-02-16

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