FR2313915A1 - Nouvelle forme galenique d'administration de la vincamine et de ses derives, son procede de preparation et medicaments comprenant cette nouvelle forme - Google Patents
Nouvelle forme galenique d'administration de la vincamine et de ses derives, son procede de preparation et medicaments comprenant cette nouvelle formeInfo
- Publication number
- FR2313915A1 FR2313915A1 FR7601947A FR7601947A FR2313915A1 FR 2313915 A1 FR2313915 A1 FR 2313915A1 FR 7601947 A FR7601947 A FR 7601947A FR 7601947 A FR7601947 A FR 7601947A FR 2313915 A1 FR2313915 A1 FR 2313915A1
- Authority
- FR
- France
- Prior art keywords
- vincamine
- deriv
- layer comprises
- microcapsules
- excipient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 title abstract 8
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002726 vincamine Drugs 0.000 title abstract 4
- 239000011248 coating agent Substances 0.000 title 1
- 238000000576 coating method Methods 0.000 title 1
- 239000003094 microcapsule Substances 0.000 title 1
- 238000013268 sustained release Methods 0.000 title 1
- 239000012730 sustained-release form Substances 0.000 title 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- 229920001577 copolymer Chemical compound 0.000 abstract 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 abstract 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 229920000084 Gum arabic Polymers 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 241000978776 Senegalia senegal Species 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 239000000205 acacia gum Substances 0.000 abstract 1
- 235000010489 acacia gum Nutrition 0.000 abstract 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 abstract 1
- 235000013681 dietary sucrose Nutrition 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 229920000591 gum Polymers 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- 229920000193 polymethacrylate Polymers 0.000 abstract 1
- -1 polyoxyethylene Polymers 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
- 229920001059 synthetic polymer Polymers 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7601947A FR2313915A1 (fr) | 1976-01-26 | 1976-01-26 | Nouvelle forme galenique d'administration de la vincamine et de ses derives, son procede de preparation et medicaments comprenant cette nouvelle forme |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7601947A FR2313915A1 (fr) | 1976-01-26 | 1976-01-26 | Nouvelle forme galenique d'administration de la vincamine et de ses derives, son procede de preparation et medicaments comprenant cette nouvelle forme |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2313915A1 true FR2313915A1 (fr) | 1977-01-07 |
| FR2313915B1 FR2313915B1 (cg-RX-API-DMAC7.html) | 1980-06-13 |
Family
ID=9168343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7601947A Granted FR2313915A1 (fr) | 1976-01-26 | 1976-01-26 | Nouvelle forme galenique d'administration de la vincamine et de ses derives, son procede de preparation et medicaments comprenant cette nouvelle forme |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2313915A1 (cg-RX-API-DMAC7.html) |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2432313A1 (fr) * | 1978-08-01 | 1980-02-29 | Foulhoux Pierre | Nouvelle forme galenique de la betahistine et son procede d'obtention |
| EP0013262A3 (en) * | 1978-12-22 | 1981-05-27 | Aktiebolaget Hassle | A pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, and a process for preparation thereof |
| EP0042818A1 (de) * | 1980-06-23 | 1981-12-30 | Ciba-Geigy Ag | Verfahren zur Herstellung von protrahiert wirkenden Vincamin-Zubereitungen, die so erhaltenen Vincamin-Zubereitungen und diese enthaltende Arzneimittel |
| WO1982001468A1 (fr) * | 1980-10-28 | 1982-05-13 | Claude Laruelle | Nouvelle forme galenique d'administration du metoclopramide, son procede de preparation et medicament comprenant cette nouvelle forme |
| FR2494112A1 (cg-RX-API-DMAC7.html) * | 1980-11-19 | 1982-05-21 | Laruelle Claude | |
| GB2151920A (en) * | 1983-12-23 | 1985-07-31 | Ile De France | Oral compositions containing sulpiride |
| EP0149920A3 (en) * | 1983-12-22 | 1985-08-28 | Elan Corporation P.L.C. | Pharmaceutical formulation |
| GB2159715A (en) * | 1984-06-04 | 1985-12-11 | Sterwin Ag | Pharmaceutical composition in sustained release unit dose form and process for its preparation |
| EP0164959A3 (en) * | 1984-06-04 | 1986-12-17 | Sterwin Ag. | Pharmaceutical composition in sustained release unit dose form and process for its preparation |
| FR2597340A1 (fr) * | 1986-03-14 | 1987-10-23 | Chiesi Farma Spa | Compositions pharmaceutiques contenant de la vinburnine et leur procede de preparation. |
| US4894240A (en) * | 1983-12-22 | 1990-01-16 | Elan Corporation Plc | Controlled absorption diltiazem formulation for once-daily administration |
| US4917899A (en) * | 1983-12-22 | 1990-04-17 | Elan Corporation Plc | Controlled absorption diltiazem formulation |
| FR2842735A1 (fr) * | 2002-07-26 | 2004-01-30 | Flamel Tech Sa | Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os |
| EP1424068A1 (de) * | 2002-11-27 | 2004-06-02 | Oramon Arzneimittel GmbH | Verfahren zur Herstellung von Pellets, enthaltend ein tri- oder tetracyclisches Antidepressivum sowie diese Pellets enthaltende pharmazeutische Zubereitungen |
| US8652523B2 (en) | 2002-07-26 | 2014-02-18 | Flamel Technologies | Oral pharmaceutical formulation in the form of a plurality of microcapsules for prolonged release of active principle(s) with slow solubility |
| US9814684B2 (en) | 2002-04-09 | 2017-11-14 | Flamel Ireland Limited | Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4369175A (en) | 1981-07-27 | 1983-01-18 | Ciba-Geigy Corporation | Process for the manufacture of prolonged action vincamine preparations, the vincamine preparations so obtained, and medicaments containing them |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| KR20050005437A (ko) | 2002-04-09 | 2005-01-13 | 플라멜 테크놀로지스 | 아목시실린의 변형 방출을 위한 마이크로캡슐 수성 현탁액형태의 경구 제약학적 제제 |
| FR2862536B1 (fr) | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques |
-
1976
- 1976-01-26 FR FR7601947A patent/FR2313915A1/fr active Granted
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2432313A1 (fr) * | 1978-08-01 | 1980-02-29 | Foulhoux Pierre | Nouvelle forme galenique de la betahistine et son procede d'obtention |
| EP0013262A3 (en) * | 1978-12-22 | 1981-05-27 | Aktiebolaget Hassle | A pharmaceutical preparation comprising a cardiac glycoside with a polymer coating, and a process for preparation thereof |
| EP0042818A1 (de) * | 1980-06-23 | 1981-12-30 | Ciba-Geigy Ag | Verfahren zur Herstellung von protrahiert wirkenden Vincamin-Zubereitungen, die so erhaltenen Vincamin-Zubereitungen und diese enthaltende Arzneimittel |
| JPS57502121A (cg-RX-API-DMAC7.html) * | 1980-10-28 | 1982-12-02 | ||
| WO1982001468A1 (fr) * | 1980-10-28 | 1982-05-13 | Claude Laruelle | Nouvelle forme galenique d'administration du metoclopramide, son procede de preparation et medicament comprenant cette nouvelle forme |
| FR2494112A1 (cg-RX-API-DMAC7.html) * | 1980-11-19 | 1982-05-21 | Laruelle Claude | |
| WO1982001649A1 (fr) * | 1980-11-19 | 1982-05-27 | Laruelle Claude | Nouvelle forme galenique du fenofibrate, son procede d'obtention, son application comme medicament |
| AT387517B (de) * | 1980-11-19 | 1989-02-10 | Claude Laruelle | Verfahren zur herstellung eines praeparates von para-aroyl-phenoxy-isobuttersaeurederivaten |
| EP0149920A3 (en) * | 1983-12-22 | 1985-08-28 | Elan Corporation P.L.C. | Pharmaceutical formulation |
| US4917899A (en) * | 1983-12-22 | 1990-04-17 | Elan Corporation Plc | Controlled absorption diltiazem formulation |
| US4894240A (en) * | 1983-12-22 | 1990-01-16 | Elan Corporation Plc | Controlled absorption diltiazem formulation for once-daily administration |
| US4891230A (en) * | 1983-12-22 | 1990-01-02 | Elan Corporation Plc | Diltiazem formulation |
| US4721619A (en) * | 1983-12-22 | 1988-01-26 | Elan Corporation P.L.C. | Controlled absorption diltiazen pharmaceutical formulation |
| GB2151920A (en) * | 1983-12-23 | 1985-07-31 | Ile De France | Oral compositions containing sulpiride |
| US4806361A (en) * | 1984-06-04 | 1989-02-21 | Sterling Drug Inc. | Medicaments in sustained release unit dose form |
| EP0164959A3 (en) * | 1984-06-04 | 1986-12-17 | Sterwin Ag. | Pharmaceutical composition in sustained release unit dose form and process for its preparation |
| GB2159715A (en) * | 1984-06-04 | 1985-12-11 | Sterwin Ag | Pharmaceutical composition in sustained release unit dose form and process for its preparation |
| FR2597340A1 (fr) * | 1986-03-14 | 1987-10-23 | Chiesi Farma Spa | Compositions pharmaceutiques contenant de la vinburnine et leur procede de preparation. |
| BE1000087A3 (fr) * | 1986-03-14 | 1988-02-02 | Chiesi Farma Spa | Compositions pharmaceutiques contenant de la vinburnine et leur procede de preparation. |
| US9814684B2 (en) | 2002-04-09 | 2017-11-14 | Flamel Ireland Limited | Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) |
| US10004693B2 (en) | 2002-04-09 | 2018-06-26 | Flamel Ireland Limited | Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) |
| WO2004010984A3 (fr) * | 2002-07-26 | 2004-04-08 | Flamel Tech Sa | Microcapsules a liberation modifiee de principes actifs peu solubles pour administration per os |
| AU2003269068B2 (en) * | 2002-07-26 | 2009-01-22 | Flamel Ireland Limited | Micropcapsules with modified release of active principles with low solubility for oral delivery |
| EP2272506A3 (fr) * | 2002-07-26 | 2013-07-10 | Flamel Technologies | Microcapsules a liberation modifiee de principes actifs peu solubles pour administration per os |
| US8652523B2 (en) | 2002-07-26 | 2014-02-18 | Flamel Technologies | Oral pharmaceutical formulation in the form of a plurality of microcapsules for prolonged release of active principle(s) with slow solubility |
| US8821935B2 (en) | 2002-07-26 | 2014-09-02 | Flamel Technologies | Microcapsules with modified release of active principles with low solubility for oral delivery |
| FR2842735A1 (fr) * | 2002-07-26 | 2004-01-30 | Flamel Tech Sa | Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os |
| EP1424068A1 (de) * | 2002-11-27 | 2004-06-02 | Oramon Arzneimittel GmbH | Verfahren zur Herstellung von Pellets, enthaltend ein tri- oder tetracyclisches Antidepressivum sowie diese Pellets enthaltende pharmazeutische Zubereitungen |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2313915B1 (cg-RX-API-DMAC7.html) | 1980-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| TP | Transmission of property | ||
| TP | Transmission of property |