FR2302303A1 - Procede et composes pour l'analyse des phosphatases - Google Patents
Procede et composes pour l'analyse des phosphatasesInfo
- Publication number
- FR2302303A1 FR2302303A1 FR7605499A FR7605499A FR2302303A1 FR 2302303 A1 FR2302303 A1 FR 2302303A1 FR 7605499 A FR7605499 A FR 7605499A FR 7605499 A FR7605499 A FR 7605499A FR 2302303 A1 FR2302303 A1 FR 2302303A1
- Authority
- FR
- France
- Prior art keywords
- phosphatases
- substrates
- thymol blue
- biological fluids
- phosphate salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 title 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 title 1
- -1 Thymol blue phosphate salts Chemical class 0.000 title 1
- 238000003556 assay Methods 0.000 title 1
- 239000013060 biological fluid Substances 0.000 title 1
- 239000000758 substrate Substances 0.000 title 1
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 abstract 2
- QHQZEEGNGSZBOL-UHFFFAOYSA-N 2-(aminomethyl)-2-(hydroxymethyl)propane-1,3-diol Chemical compound NCC(CO)(CO)CO QHQZEEGNGSZBOL-UHFFFAOYSA-N 0.000 abstract 1
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 abstract 1
- AJWNKVQIJBTSDM-UHFFFAOYSA-N 5-[(oxo-lambda5-phosphanylidyne)methyl]-2-propan-2-ylphenol Chemical compound P(=O)#CC1=CC(=C(C=C1)C(C)C)O AJWNKVQIJBTSDM-UHFFFAOYSA-N 0.000 abstract 1
- 102000013563 Acid Phosphatase Human genes 0.000 abstract 1
- 108010051457 Acid Phosphatase Proteins 0.000 abstract 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 abstract 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 206010020850 Hyperthyroidism Diseases 0.000 abstract 1
- 206010067125 Liver injury Diseases 0.000 abstract 1
- VCCIAAPOKIZVON-UHFFFAOYSA-N [4-[3-(4-hydroxy-2-methyl-5-propan-2-ylphenyl)-1,1-dioxo-2,1$l^{6}-benzoxathiol-3-yl]-5-methyl-2-propan-2-ylphenyl] dihydrogen phosphate Chemical class C1=C(O)C(C(C)C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C(=CC(OP(O)(O)=O)=C(C(C)C)C=2)C)=C1C VCCIAAPOKIZVON-UHFFFAOYSA-N 0.000 abstract 1
- 230000004097 bone metabolism Effects 0.000 abstract 1
- 239000003593 chromogenic compound Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 231100000234 hepatic damage Toxicity 0.000 abstract 1
- 230000008818 liver damage Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/40—Triphenylmethane dye chromogens, e.g. fluorescein derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55400775A | 1975-02-28 | 1975-02-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2302303A1 true FR2302303A1 (fr) | 1976-09-24 |
| FR2302303B1 FR2302303B1 (fr) | 1981-08-07 |
Family
ID=24211682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7605499A Granted FR2302303A1 (fr) | 1975-02-28 | 1976-02-27 | Procede et composes pour l'analyse des phosphatases |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE839048A (fr) |
| CA (1) | CA1077498A (fr) |
| FR (1) | FR2302303A1 (fr) |
| ZA (1) | ZA761215B (fr) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1448348A (fr) * | 1964-10-01 | 1966-08-05 | Warner Lambert Pharmaceutical | Dérivés de la phénolphtaléine |
| US3331862A (en) * | 1964-06-05 | 1967-07-18 | Warner Lambert Pharmaceutical | Phenolphthalein-mono-phosphate derivatives |
| FR2022180A1 (fr) * | 1968-09-20 | 1970-07-31 | Merck Ag E |
-
1976
- 1976-02-26 CA CA246,659A patent/CA1077498A/fr not_active Expired
- 1976-02-27 BE BE164741A patent/BE839048A/fr unknown
- 1976-02-27 FR FR7605499A patent/FR2302303A1/fr active Granted
- 1976-03-01 ZA ZA761215A patent/ZA761215B/xx unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3331862A (en) * | 1964-06-05 | 1967-07-18 | Warner Lambert Pharmaceutical | Phenolphthalein-mono-phosphate derivatives |
| FR1448348A (fr) * | 1964-10-01 | 1966-08-05 | Warner Lambert Pharmaceutical | Dérivés de la phénolphtaléine |
| FR2022180A1 (fr) * | 1968-09-20 | 1970-07-31 | Merck Ag E |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA761215B (en) | 1977-02-23 |
| BE839048A (fr) | 1976-06-16 |
| CA1077498A (fr) | 1980-05-13 |
| FR2302303B1 (fr) | 1981-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |