FR22C1052I1 - HUMANIZED ANTI-CD19 ANTIBODIES AND THEIR USE IN THE TREATMENT OF TUMOURS, TRANSPLANTATION AND AUTOIMMUNE DISEASES - Google Patents
HUMANIZED ANTI-CD19 ANTIBODIES AND THEIR USE IN THE TREATMENT OF TUMOURS, TRANSPLANTATION AND AUTOIMMUNE DISEASESInfo
- Publication number
- FR22C1052I1 FR22C1052I1 FR22C1052C FR22C1052C FR22C1052I1 FR 22C1052 I1 FR22C1052 I1 FR 22C1052I1 FR 22C1052 C FR22C1052 C FR 22C1052C FR 22C1052 C FR22C1052 C FR 22C1052C FR 22C1052 I1 FR22C1052 I1 FR 22C1052I1
- Authority
- FR
- France
- Prior art keywords
- treatment
- antibodies
- transplantation
- tumours
- autoimmune diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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Abstract
The present invention provides chimeric and humanized versions of anti-CD19 mouse monoclonal antibodies. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human CD19 antigen and that may mediate ADCC, CDC, and/or apoptosis for the treatment of B cell diseases and disorders, such as, but not limited to, B cell malignancies, for the treatment and prevention of autoimmune disease, and for the treatment and prevention of graft-versus-host disease (GVHD), humoral rejection, and post-transplantation lymphoproliferative disorder in human transplant recipients.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84293506P | 2006-09-08 | 2006-09-08 | |
US86691706P | 2006-11-22 | 2006-11-22 | |
US91139707P | 2007-04-12 | 2007-04-12 | |
US91530907P | 2007-05-01 | 2007-05-01 | |
US93942907P | 2007-05-22 | 2007-05-22 | |
PCT/US2007/077916 WO2008031056A2 (en) | 2006-09-08 | 2007-09-07 | Humanized anti-cd19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
Publications (2)
Publication Number | Publication Date |
---|---|
FR22C1052I1 true FR22C1052I1 (en) | 2022-12-16 |
FR22C1052I2 FR22C1052I2 (en) | 2023-12-15 |
Family
ID=39158111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR22C1052C Active FR22C1052I2 (en) | 2006-09-08 | 2022-10-17 | HUMANIZED ANTI-CD19 ANTIBODIES AND THEIR USE IN THE TREATMENT OF TUMORS, TRANSPLANTATION AND AUTOIMMUNE DISEASES |
Country Status (20)
Country | Link |
---|---|
US (5) | US8323653B2 (en) |
EP (1) | EP2066349B1 (en) |
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