FR22C1052I1 - HUMANIZED ANTI-CD19 ANTIBODIES AND THEIR USE IN THE TREATMENT OF TUMOURS, TRANSPLANTATION AND AUTOIMMUNE DISEASES - Google Patents

HUMANIZED ANTI-CD19 ANTIBODIES AND THEIR USE IN THE TREATMENT OF TUMOURS, TRANSPLANTATION AND AUTOIMMUNE DISEASES

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Publication number
FR22C1052I1
FR22C1052I1 FR22C1052C FR22C1052C FR22C1052I1 FR 22C1052 I1 FR22C1052 I1 FR 22C1052I1 FR 22C1052 C FR22C1052 C FR 22C1052C FR 22C1052 C FR22C1052 C FR 22C1052C FR 22C1052 I1 FR22C1052 I1 FR 22C1052I1
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France
Prior art keywords
treatment
antibodies
transplantation
tumours
autoimmune diseases
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FR22C1052C
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French (fr)
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Viela Bio Inc
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Viela Bio Inc
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Publication of FR22C1052I1 publication Critical patent/FR22C1052I1/en
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Publication of FR22C1052I2 publication Critical patent/FR22C1052I2/en
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Abstract

The present invention provides chimeric and humanized versions of anti-CD19 mouse monoclonal antibodies. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human CD19 antigen and that may mediate ADCC, CDC, and/or apoptosis for the treatment of B cell diseases and disorders, such as, but not limited to, B cell malignancies, for the treatment and prevention of autoimmune disease, and for the treatment and prevention of graft-versus-host disease (GVHD), humoral rejection, and post-transplantation lymphoproliferative disorder in human transplant recipients.
FR22C1052C 2006-09-08 2022-10-17 HUMANIZED ANTI-CD19 ANTIBODIES AND THEIR USE IN THE TREATMENT OF TUMORS, TRANSPLANTATION AND AUTOIMMUNE DISEASES Active FR22C1052I2 (en)

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US93942907P 2007-05-22 2007-05-22
PCT/US2007/077916 WO2008031056A2 (en) 2006-09-08 2007-09-07 Humanized anti-cd19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease

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