FR22C1032I1 - ANTI-CGRP COMPOSITIONS AND THEIR USE - Google Patents

ANTI-CGRP COMPOSITIONS AND THEIR USE

Info

Publication number
FR22C1032I1
FR22C1032I1 FR22C1032C FR22C1032C FR22C1032I1 FR 22C1032 I1 FR22C1032 I1 FR 22C1032I1 FR 22C1032 C FR22C1032 C FR 22C1032C FR 22C1032 C FR22C1032 C FR 22C1032C FR 22C1032 I1 FR22C1032 I1 FR 22C1032I1
Authority
FR
France
Prior art keywords
cgrp compositions
cgrp
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR22C1032C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47175055&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR22C1032(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of FR22C1032I1 publication Critical patent/FR22C1032I1/en
Application granted granted Critical
Publication of FR22C1032I2 publication Critical patent/FR22C1032I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR22C1032C 2011-05-20 2022-06-29 ANTI-CGRP COMPOSITIONS AND THEIR USE Active FR22C1032I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161488660P 2011-05-20 2011-05-20
PCT/US2012/038844 WO2012162243A2 (en) 2011-05-20 2012-05-21 Anti-cgrp compositions and use thereof
EP12789693.4A EP2710039B1 (en) 2011-05-20 2012-05-21 Anti-cgrp compositions and use thereof

Publications (2)

Publication Number Publication Date
FR22C1032I1 true FR22C1032I1 (en) 2022-09-09
FR22C1032I2 FR22C1032I2 (en) 2023-06-02

Family

ID=47175055

Family Applications (1)

Application Number Title Priority Date Filing Date
FR22C1032C Active FR22C1032I2 (en) 2011-05-20 2022-06-29 ANTI-CGRP COMPOSITIONS AND THEIR USE

Country Status (36)

Country Link
US (10) US9745373B2 (en)
EP (5) EP3662932B1 (en)
JP (3) JP6282584B2 (en)
KR (1) KR102128627B1 (en)
CN (5) CN107586338B (en)
AP (1) AP2013007259A0 (en)
AR (3) AR086516A1 (en)
AU (3) AU2012258966C1 (en)
BR (2) BR112013029932A2 (en)
CA (3) CA2836649C (en)
CL (3) CL2013003336A1 (en)
CO (1) CO6870005A2 (en)
CY (2) CY1124209T1 (en)
DK (3) DK3495392T3 (en)
EA (3) EA031065B1 (en)
ES (3) ES2893073T3 (en)
FR (1) FR22C1032I2 (en)
HR (3) HRP20190640T1 (en)
HU (4) HUE055505T2 (en)
IL (4) IL229431B (en)
LT (4) LT3662932T (en)
MX (3) MX370749B (en)
NL (1) NL301181I2 (en)
NO (1) NO2022029I1 (en)
NZ (1) NZ733060A (en)
PE (2) PE20180502A1 (en)
PH (1) PH12018500521A1 (en)
PL (3) PL2710039T3 (en)
PT (3) PT3662932T (en)
RS (3) RS61793B1 (en)
SG (2) SG10201604040PA (en)
SI (3) SI2710039T1 (en)
TR (1) TR201904088T4 (en)
TW (4) TWI646111B (en)
WO (1) WO2012162243A2 (en)
ZA (1) ZA201308637B (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS20080200A (en) 2005-11-14 2009-07-15 Rinat Neuroscience Corp., Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
ES2689322T3 (en) 2008-03-04 2018-11-13 Teva Pharmaceuticals International Gmbh Methods to treat chronic pain
BR112013029959A8 (en) 2011-05-20 2021-09-08 Alderbio Holdings Llc Anti-cgrp and anti-cgrpr antibodies and their use to prevent or inhibit photophobia or aversion to light, pharmaceutical composition comprising said antibodies, as well as nucleic acid sequence and recombinant cell
EP2709662B1 (en) 2011-05-20 2019-07-31 AlderBio Holdings LLC Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea
EP3662932B1 (en) * 2011-05-20 2021-04-07 H. Lundbeck A/S Anti-cgrp compositions and use thereof
AR095615A1 (en) * 2013-03-15 2015-10-28 Alder Biopharmaceuticals Inc PURIFICATION OF ANTIBODIES AND PURITY MONITORING
US20170114122A1 (en) 2015-10-23 2017-04-27 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
US20150017166A1 (en) * 2013-07-03 2015-01-15 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
LT3119431T (en) 2014-03-21 2024-03-12 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
AU2016249140B8 (en) 2015-04-16 2022-07-21 H. Lundbeck A/S. Anti-PACAP antibodies and uses thereof
JOP20200116A1 (en) 2015-04-24 2017-06-16 Amgen Inc Methods for treating or preventing migraine headache
AR104847A1 (en) * 2015-06-17 2017-08-16 Lilly Co Eli FORMULATION OF ANTI-CGRP ANTIBODY
CA2999809A1 (en) * 2015-09-24 2017-03-30 Teva Pharmaceuticals International Gmbh Preventing, treating, and reducing (persistent) post-traumatic headache
TW201725212A (en) * 2015-12-10 2017-07-16 第一三共股份有限公司 Novel proteins specific for calcitonin gene-related peptide
US20190031748A1 (en) * 2016-01-28 2019-01-31 Eli Lilly And Company Cgrp antibodies and uses thereof
US11492386B2 (en) 2016-02-01 2022-11-08 Eli Lilly And Company Parathyroid hormone-anti-RANKL antibody fusion compounds
SG10202109689QA (en) 2016-04-15 2021-10-28 Alder Biopharmaceuticals Inc Humanized anti-pacap antibodies and uses thereof
WO2018055574A1 (en) 2016-09-23 2018-03-29 Teva Pharmaceuticals International Gmbh Treating refractory migraine
AU2017331592A1 (en) 2016-09-23 2019-04-11 Teva Pharmaceuticals International Gmbh Treating cluster headache
JP7195262B2 (en) 2017-03-02 2022-12-23 ベス イスラエル デアコネス メディカル センター インコーポレイティッド Method for Selecting Headache Patients Responsive to Antibodies Directed to Calcitonin Gene-Related Peptides
EP3610019A4 (en) * 2017-04-19 2021-05-12 John Mansell Compositions and methods for treating pain disorders
CN111566126A (en) 2018-01-12 2020-08-21 美国安进公司 PAC1 antibodies and uses thereof
US11274158B2 (en) * 2018-01-30 2022-03-15 Flagship Pioneering Innovations V, Inc. Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators
CN112040949A (en) 2018-02-23 2020-12-04 瑞美德生物医药科技有限公司 Calcitonin Gene Related Peptide (CGRP) antagonist antibodies
WO2019231800A1 (en) * 2018-05-31 2019-12-05 Eli Lilly And Company Anti-cgrp antibodies for treating menstrual-related migraines
US10899826B1 (en) * 2018-09-13 2021-01-26 Teva Pharmaceuticals International Gmbh Pharmaceutical compositions for an anti-CGRP antagonist antibody
EP3674418A1 (en) * 2018-12-26 2020-07-01 Life Length S.L. Method for measuring telomere associated variables and uses thereof for the diagnosis and/or prognosis of telomeric-associated diseases
TW202030205A (en) * 2019-01-08 2020-08-16 美商Ａｌｄｅｒ製藥公司 Treatment of medication overuse headache using anti-cgrp or anti-cgrp-r antibodies
TWI839435B (en) * 2019-01-08 2024-04-21 丹麥商Ｈ．朗德貝克公司 Acute treatment and rapid treatment of headache using anti-cgrp antibodies
WO2020175936A1 (en) * 2019-02-28 2020-09-03 단디바이오사이언스 주식회사 Polypeptide having antibacterial activity, composition for preventing or treating sepsis comprising same, and antibacterial composition
MA55815A (en) * 2019-05-02 2022-03-09 H Lundbeck As TREATMENT OF HEADACHES USING ANTI-CGRP ANTIBODIES
CN114127110B (en) * 2019-05-30 2022-07-01 山东博安生物技术股份有限公司 anti-CGRP antibodies and uses thereof
AU2020202454A1 (en) 2020-04-06 2021-10-21 H. Lundbeck A/S Treatment of most bothersome symptom (MBS) associated with migraine using anti-CGRP antibodies
CA3212151A1 (en) 2021-03-02 2022-09-09 Cgrp Diagnostics Gmbh Treatment and/or reduction of occurrence of migraine
WO2023026205A1 (en) 2021-08-24 2023-03-02 Cgrp Diagnostics Gmbh Preventative treatment of migraine
IL310885A (en) 2021-08-27 2024-04-01 H Lundbeck As Treatment of cluster headache using anti-cgrp antibodies
AU2023223603A1 (en) 2022-02-28 2024-08-22 Tridem Bioscience Gmbh & Co Kg A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN.
CN117586390A (en) * 2022-08-11 2024-02-23 上海君实生物医药科技股份有限公司 anti-CGRP antibodies and uses
CN118271438B (en) * 2024-05-27 2024-08-30 上海宏成药业有限公司 Anti-CGRP antibodies or antigen binding fragments thereof and uses thereof

Family Cites Families (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3662333A (en) 1970-09-08 1972-05-09 Bendix Corp Hydraulic accumulator charge detector and indicating system
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS5123197A (en) 1974-08-21 1976-02-24 Hitachi Ltd PUROSESUGASUKUROMATOGURAFUNO ONDOSEIGYOHOSHIKI
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DE134631T1 (en) * 1983-06-15 1985-12-05 Roger Kingdom Craig PEPTIDES, PHARMACEUTICAL COMPOSITIONS, GENES, VECTORS, HOST ORGANISMS, METHODS FOR THEIR PRODUCTION AND DIAGNOSTIC REAGENTS.
JPS62129297A (en) 1985-08-09 1987-06-11 Toyo Jozo Co Ltd Calcitonin gene related peptide derivative
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
GB8725529D0 (en) 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
US5266561A (en) 1988-01-11 1993-11-30 Amylin Pharmaceuticals, Inc. Treatment of type 2 diabetes mellitus
US5364841A (en) 1988-01-11 1994-11-15 Amylin Pharmaceuticals, Inc. Treatment of obesity and essential hypertension and related disorders
ATE135370T1 (en) 1988-12-22 1996-03-15 Kirin Amgen Inc CHEMICALLY MODIFIED GRANULOCYTE COLONY EXCITING FACTOR
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5766883A (en) 1989-04-29 1998-06-16 Delta Biotechnology Limited Polypeptides
FR2650598B1 (en) 1989-08-03 1994-06-03 Rhone Poulenc Sante DERIVATIVES OF ALBUMIN WITH THERAPEUTIC FUNCTION
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
FR2669336B1 (en) 1990-11-20 1993-01-22 Adir NOVEL OXAZOLO PYRIDINES DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US6407213B1 (en) 1991-06-14 2002-06-18 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
FR2686899B1 (en) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE4227454C1 (en) * 1992-08-19 1994-02-03 Henning Berlin Gmbh Process for early detection, for the detection of the severity as well as for the therapy-accompanying assessment of the course of sepsis as well as means for carrying out the process
US5604260A (en) 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
US5409944A (en) 1993-03-12 1995-04-25 Merck Frosst Canada, Inc. Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
WO1994021293A1 (en) 1993-03-19 1994-09-29 Duke University Method of treatment of tumors with an antibody binding to tenascin
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5436265A (en) 1993-11-12 1995-07-25 Merck Frosst Canada, Inc. 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5475995A (en) 1994-05-16 1995-12-19 Livingston; George G. Truck spare tire locking rod
US5616601A (en) 1994-07-28 1997-04-01 Gd Searle & Co 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
DE69534530T2 (en) 1994-08-12 2006-07-06 Immunomedics, Inc. FOR B-CELL LYMPHOMA AND LEUKEMIA SPECIMEN IMMUNOCONJUGATES AND HUMAN ANTIBODIES
JPH10504457A (en) 1994-08-16 1998-05-06 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド Calcitonin receptor
US5521213A (en) 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5593994A (en) 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors
US5552422A (en) 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
FR2732221B1 (en) 1995-03-28 1997-04-25 Oreal USE OF A CGRP ANTAGONIST TO TREAT CUTANEOUS REDNESS OF NEUROGENIC ORIGIN AND COMPOSITION OBTAINED
US5639780A (en) 1995-05-22 1997-06-17 Merck Frosst Canada, Inc. N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors
US5510368A (en) 1995-05-22 1996-04-23 Merck Frosst Canada, Inc. N-benzyl-3-indoleacetic acids as antiinflammatory drugs
US5604253A (en) 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
WO1997009046A1 (en) 1995-09-05 1997-03-13 Smithkline Beecham Corporation Compounds and methods
US5710024A (en) * 1996-07-23 1998-01-20 Smithkline Beecham Corporation Polynucleotides that encode the calcitonin gene-related peptide receptor coponent factor (HOUNDC44)
CA2264942A1 (en) 1996-09-09 1998-03-12 Smithkline Beecham Corporation Compounds and methods
EA004037B1 (en) 1996-09-10 2003-12-25 Др. Карл Томэ ГмбХ Modified aminoacids, pharmaceuticals on their base
US6653104B2 (en) 1996-10-17 2003-11-25 Immunomedics, Inc. Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
WO1998056779A1 (en) 1997-06-13 1998-12-17 Smithkline Beecham Corporation 4-sulfinyl benzamides as calcitonin gene-related peptide receptor antagonists
US6956107B2 (en) 1998-02-20 2005-10-18 Tanox, Inc. Inhibitors of complement activation
US6552043B1 (en) 1998-09-30 2003-04-22 Merck Sharpe & Dohme Ltd. Benzimidazolinyl piperidines as CGRP ligands
US20010036647A1 (en) 1998-10-22 2001-11-01 Prabhakara V. Choudary Functionally assembled antigen-specific intact recombinant antibody and a method for production thereof
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP1031350A1 (en) 1999-02-23 2000-08-30 Warner-Lambert Company Use of a gabapentin-analog for the manufacture of a medicament for preventing and treating visceral pain
US6313097B1 (en) 1999-03-02 2001-11-06 Boehringer Ingelheim Pharma Kg Antagonists of calcitonin gene-related peptide
US6521609B1 (en) 1999-08-10 2003-02-18 Boehringer Ingelheim Pharma Kg Use of CGRP antagonists and CGRP release inhibitors for combating menopausal hot flushes
UA77152C2 (en) 1999-09-25 2006-11-15 Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma
DK1259547T3 (en) 2000-03-01 2012-10-15 Medimmune Inc HIGH POTENTIAL, RECOMBINANT ANTIBODIES AND PROCEDURE FOR PRODUCING THEM
US6406863B1 (en) 2000-06-23 2002-06-18 Genetastix Corporation High throughput generation and screening of fully human antibody repertoire in yeast
US20020162125A1 (en) 2001-03-06 2002-10-31 Anne-Marie Salmon Methods and compositions for the modulation of neurogenic inflammatory pain and physical opiate withdrawal
US20030181462A1 (en) 2001-08-17 2003-09-25 Boehringer Ingelheim Pharma Kg Use of BIBN4096 in combination with other antimigraine drugs for the treatment of migraine
AU2002356469A1 (en) 2001-11-26 2003-06-10 Protemix Corp Ltd Methods of compositions for normalizing lipid levels in mammalian tissues
WO2003085089A2 (en) 2002-03-29 2003-10-16 Schering Corporation Human monoclonal antibodies to interleukin-5 and methods and compositions comprising same
WO2003093472A2 (en) 2002-05-06 2003-11-13 Grünenthal GmbH Cgrp binding nucleic acids
US20040110170A1 (en) 2002-05-18 2004-06-10 The Regents Of The University Of California Cloning and characterization of calcitonin gene related peptide receptors
US7345065B2 (en) 2002-05-21 2008-03-18 Allergan, Inc. Methods and compositions for alleviating pain
PL374017A1 (en) 2002-06-05 2005-09-19 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
CN1678634A (en) 2002-06-28 2005-10-05 多曼蒂斯有限公司 Immunoglobulin single variable antigen combination area and its opposite constituent
RS52750B (en) 2002-08-12 2013-08-30 Birkir Sveinsson Use of cgrp antagonist compounds for treatment of psoriasis
UA80447C2 (en) 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
DE10250082A1 (en) 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals
AU2003298816C1 (en) 2002-12-02 2010-12-16 Amgen Fremont, Inc. Antibodies directed to Tumor Necrosis Factor and uses thereof
KR101250818B1 (en) 2002-12-24 2013-04-15 리나트 뉴로사이언스 코프. Anti-ngf antibodies and methods using same
WO2004087649A2 (en) 2003-03-14 2004-10-14 Merck & Co., Inc. Benodiazepine spirohydantoin cgrp receptor antagonists
AU2004221891B2 (en) 2003-03-14 2009-11-19 Merck Sharp & Dohme Corp. Monocyclic anilide spirohydantoin CGRP receptor antagonists
AU2004222378B2 (en) 2003-03-14 2008-08-14 Merck Sharp & Dohme Corp. Carboxamide spirohydantoin CGRP receptor antagonists
AU2004222328B2 (en) 2003-03-14 2009-10-08 Merck Sharp & Dohme Corp. Aryl spirohydantoin CGRP receptor antagonists
DE602004013563D1 (en) 2003-03-14 2008-06-19 Merck & Co Inc RANTAGONISTEN
JO2355B1 (en) 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن CGRP receptor antagonists
CA2522024A1 (en) 2003-04-15 2004-10-28 Merck & Co., Inc. Cgrp receptor antagonists
WO2004097421A2 (en) 2003-04-29 2004-11-11 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with calcitonin receptor-like receptor (calcrl)
CN100418948C (en) 2003-07-15 2008-09-17 麦克公司 Hydroxypyridine cgrp receptor antagonists
HUE033349T2 (en) * 2003-10-22 2017-11-28 Keck Graduate Inst Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy
WO2005041757A2 (en) 2003-10-29 2005-05-12 University Of Rochester Detection of neuropeptides associated with pelvic pain disorders and uses thereof
US20090023644A1 (en) 2004-01-13 2009-01-22 Southard Jeffery L Methods of using cgrp for cardiovascular and renal indications
DE102004015723A1 (en) 2004-03-29 2005-10-20 Boehringer Ingelheim Pharma Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals
US7279471B2 (en) 2004-04-15 2007-10-09 Boehringer Ingelheim International Gmbh Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
DE102004018794A1 (en) 2004-04-15 2005-10-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals
TWI432196B (en) 2005-01-18 2014-04-01 Euro Celtique Sa Method of treating visceral pain
EP1770091A1 (en) 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP-antagonists, process for their preparation as well as their use as medicaments
ITRM20050290A1 (en) 2005-06-07 2006-12-08 Lay Line Genomics Spa USE OF MOLECULES ABLE TO INHIBIT THE BOND BETWEEN NGF AND ITS TRKA RECEPTOR AS AN EXTENDED EFFECT ANALGESICS.
WO2007025212A2 (en) 2005-08-25 2007-03-01 Wex Pharmaceuticals, Inc. Use of sodium channel blockers for the treatment of visceral pain or pain caused by cancer treatment
US8168592B2 (en) 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
US20070108378A1 (en) 2005-11-14 2007-05-17 Toru Terabayashi High pressure optical cell for a downhole optical fluid analyzer
RS20080200A (en) 2005-11-14 2009-07-15 Rinat Neuroscience Corp., Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
DE602006019304D1 (en) 2005-11-18 2011-02-10 Merck Sharp & Dohme Spirohydantoin-ARYL-CGRP receptor antagonists
WO2007076336A1 (en) * 2005-12-22 2007-07-05 Eli Lilly And Company Treatment of migraine with anti-cgrp antibodies
US9074352B2 (en) 2006-03-27 2015-07-07 John R. Ramun Universal control scheme for mobile hydraulic equipment and method for achieving the same
CN101600793B (en) 2006-05-19 2013-06-26 奥尔德生物制药公司 Culture method for obtaining a clonal population of antigen-specific b cells
PE20080370A1 (en) 2006-06-08 2008-06-13 Boehringer Ingelheim Int QUINAZOLINONE DERIVATIVES AS ANTAGONISTS OF CGRP
ATE469895T1 (en) 2006-07-21 2010-06-15 Vertex Pharma CGRP RECEPTOR ANTAGONISTS
US8075902B2 (en) * 2007-01-03 2011-12-13 Michael Powell Diagnosis and treatment of cancer related to human dormancy
MX2009012493A (en) 2007-05-21 2010-01-20 Alder Biopharmaceuticals Inc Novel rabbit antibody humanization methods and humanized rabbit antibodies.
ES2610607T3 (en) 2007-05-21 2017-04-28 Alderbio Holdings Llc Antibodies against IL-6 and their uses
TW201531484A (en) 2007-05-21 2015-08-16 Alder Biopharmaceuticals Inc Antibodies to TNF alpha and use thereof
GB0725103D0 (en) * 2007-12-21 2008-01-30 Glaxo Group Ltd Novel compounds
PL2265288T3 (en) 2008-03-04 2017-01-31 Labrys Biologics Inc Methods of treating inflammatory pain
ES2689322T3 (en) 2008-03-04 2018-11-13 Teva Pharmaceuticals International Gmbh Methods to treat chronic pain
JO3382B1 (en) 2008-12-23 2019-03-13 Amgen Inc Human cgrp receptor binding antibodies
WO2011024113A1 (en) 2009-08-28 2011-03-03 Rinat Neuroscience Corporation Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide
AR081434A1 (en) 2010-06-10 2012-08-29 Lilly Co Eli ANTIBODY OF THE PEPTIDE RELATED TO THE CALCITONINE GENE (CGRP), PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, USE OF THE ANTIBODY TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT PAIN OR MIGRANE PAIN AND ANOGEN ANOGEN FRAGMENT
US11214610B2 (en) * 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
BR112013029959A8 (en) 2011-05-20 2021-09-08 Alderbio Holdings Llc Anti-cgrp and anti-cgrpr antibodies and their use to prevent or inhibit photophobia or aversion to light, pharmaceutical composition comprising said antibodies, as well as nucleic acid sequence and recombinant cell
EP3662932B1 (en) 2011-05-20 2021-04-07 H. Lundbeck A/S Anti-cgrp compositions and use thereof
EP2709662B1 (en) 2011-05-20 2019-07-31 AlderBio Holdings LLC Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea
US20170114122A1 (en) 2015-10-23 2017-04-27 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
CA2999809A1 (en) 2015-09-24 2017-03-30 Teva Pharmaceuticals International Gmbh Preventing, treating, and reducing (persistent) post-traumatic headache
JP7195262B2 (en) * 2017-03-02 2022-12-23 ベス イスラエル デアコネス メディカル センター インコーポレイティッド Method for Selecting Headache Patients Responsive to Antibodies Directed to Calcitonin Gene-Related Peptides
US11752099B2 (en) * 2017-03-27 2023-09-12 W. L. Gore & Associates, Inc. Injectable and biodegradable polymer formulations for controlled release of bioactive agents
US11400136B2 (en) * 2017-06-19 2022-08-02 President And Fellows Of Harvard College Methods and compositions for treating a microbial infection
TWI754772B (en) * 2017-09-06 2022-02-11 美商美國禮來大藥廠 Combination therapy of lasmiditan and a cgrp antagonist for use in the treatment of migraine
TW202030205A (en) 2019-01-08 2020-08-16 美商Ａｌｄｅｒ製藥公司 Treatment of medication overuse headache using anti-cgrp or anti-cgrp-r antibodies
TWI839435B (en) * 2019-01-08 2024-04-21 丹麥商Ｈ．朗德貝克公司 Acute treatment and rapid treatment of headache using anti-cgrp antibodies

Also Published As

Publication number Publication date
PE20141787A1 (en) 2014-12-07
US20180215815A1 (en) 2018-08-02
IL270382B (en) 2020-11-30
US20170174754A1 (en) 2017-06-22
EA201891284A1 (en) 2018-11-30
EA201301295A1 (en) 2014-04-30
CN103748111A (en) 2014-04-23
CY1124209T1 (en) 2022-05-27
CN108373502A (en) 2018-08-07
HRP20190640T1 (en) 2019-05-31
US9745373B2 (en) 2017-08-29
WO2012162243A2 (en) 2012-11-29
HRP20211395T1 (en) 2021-12-10
JP2014517699A (en) 2014-07-24
AR123876A2 (en) 2023-01-18
RS62306B1 (en) 2021-09-30
US10066009B2 (en) 2018-09-04
NZ717570A (en) 2018-09-28
TWI646111B (en) 2019-01-01
PH12018500521A1 (en) 2019-04-15
NZ733060A (en) 2022-08-26
CL2017001379A1 (en) 2017-12-29
ES2715001T3 (en) 2019-05-31
AP2013007259A0 (en) 2013-11-30
CA2836649A1 (en) 2012-11-29
US10214582B2 (en) 2019-02-26
US20180215813A1 (en) 2018-08-02
TWI719869B (en) 2021-02-21
US10189895B2 (en) 2019-01-29
IL261927B (en) 2019-11-28
HUS2200031I1 (en) 2022-07-28
IL268464B (en) 2020-10-29
CN108373502B (en) 2022-03-22
NZ618637A (en) 2016-03-31
JP2018038391A (en) 2018-03-15
EP3662932A1 (en) 2020-06-10
TW201936642A (en) 2019-09-16
IL229431A0 (en) 2014-01-30
EP3662932B1 (en) 2021-04-07
LT2710039T (en) 2019-04-25
TW202033559A (en) 2020-09-16
JP6282584B2 (en) 2018-02-21
TWI685505B (en) 2020-02-21
US20120294797A1 (en) 2012-11-22
BR122022012930B1 (en) 2023-10-10
MX2019015745A (en) 2020-02-13
US20240174738A1 (en) 2024-05-30
US20190211085A1 (en) 2019-07-11
EP2710039A2 (en) 2014-03-26
TR201904088T4 (en) 2019-05-21
PT3662932T (en) 2021-05-14
US20190092842A1 (en) 2019-03-28
AU2017203890B2 (en) 2019-06-06
KR20140042819A (en) 2014-04-07
US20210047391A1 (en) 2021-02-18
CA2836649C (en) 2020-06-23
MX370749B (en) 2019-12-20
AU2012258966B2 (en) 2017-03-09
BR112013029932A2 (en) 2017-01-31
RS61793B1 (en) 2021-06-30
CN108424452B (en) 2021-08-03
LT3495392T (en) 2021-09-27
SI2710039T1 (en) 2019-05-31
EP4115905A1 (en) 2023-01-11
HUE054437T2 (en) 2021-09-28
HUE044062T2 (en) 2019-09-30
CN108424452A (en) 2018-08-21
EA039905B1 (en) 2022-03-25
TW201300419A (en) 2013-01-01
EP3875115A1 (en) 2021-09-08
IL261927A (en) 2018-10-31
AU2019226231B2 (en) 2021-06-03
IL229431B (en) 2018-10-31
TWI692485B (en) 2020-05-01
US11111289B2 (en) 2021-09-07
ZA201308637B (en) 2022-11-30
DK2710039T3 (en) 2019-04-01
PT3495392T (en) 2021-09-22
WO2012162243A3 (en) 2013-01-17
PT2710039T (en) 2019-04-23
NO2022029I1 (en) 2022-07-08
MX2013013535A (en) 2015-08-20
CA3080000A1 (en) 2012-11-29
SG194938A1 (en) 2013-12-30
SI3662932T1 (en) 2021-08-31
TW201811835A (en) 2018-04-01
NL301181I2 (en) 2022-11-24
EP3495392B1 (en) 2021-08-18
MX2019008185A (en) 2019-09-09
CA3079978A1 (en) 2012-11-29
AU2017203890A1 (en) 2017-06-29
ES2873837T3 (en) 2021-11-04
EA201592042A1 (en) 2016-03-31
CL2018001452A1 (en) 2018-08-10
EP3495392A1 (en) 2019-06-12
FR22C1032I2 (en) 2023-06-02
LT3662932T (en) 2021-06-10
SI3495392T1 (en) 2021-11-30
JP6527563B2 (en) 2019-06-05
PL3495392T3 (en) 2021-12-13
CY1124515T1 (en) 2022-07-22
US10208112B2 (en) 2019-02-19
CN107602700A (en) 2018-01-19
CN107602700B (en) 2021-12-17
AR086516A1 (en) 2013-12-18
CN107586338B (en) 2021-09-17
IL268464A (en) 2019-09-26
PL3662932T3 (en) 2021-09-06
PL2710039T3 (en) 2019-07-31
RS58621B1 (en) 2019-05-31
JP6952736B2 (en) 2021-10-20
PE20180502A1 (en) 2018-03-09
EP2710039A4 (en) 2014-11-19
SG10201604040PA (en) 2016-07-28
LTPA2022511I1 (en) 2022-07-11
US10179809B2 (en) 2019-01-15
DK3495392T3 (en) 2021-09-13
US10533048B2 (en) 2020-01-14
KR102128627B1 (en) 2020-06-30
JP2019150044A (en) 2019-09-12
CN107586338A (en) 2018-01-16
NL301181I1 (en) 2022-06-15
DK3662932T3 (en) 2021-05-17
ES2893073T3 (en) 2022-02-07
EA031065B1 (en) 2018-11-30
HRP20210777T1 (en) 2021-06-25
EP2710039B1 (en) 2019-01-09
US20180215814A1 (en) 2018-08-02
AU2012258966C1 (en) 2022-02-03
CL2013003336A1 (en) 2014-06-06
AR118605A2 (en) 2021-10-20
HUE055505T2 (en) 2021-11-29
CN103748111B (en) 2018-04-27
AU2019226231A1 (en) 2019-09-26
CO6870005A2 (en) 2014-02-20
US20180215816A1 (en) 2018-08-02

Similar Documents

Publication Publication Date Title
FR22C1032I2 (en) ANTI-CGRP COMPOSITIONS AND THEIR USE
FR21C1038I2 (en) SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE
CY2022019I1 (en) ANTI-CGRP COMPOSITIONS AND USES THEREOF
FR20C1068I2 (en) ANTI-PD-L1 ANTIBODIES AND THEIR USE
BR112013032426A2 (en) probiotic compositions and methods
BR112013023776A2 (en) composition and seal-sealed opening
BR112013017629A2 (en) recombinant laminin-521
DK3385421T3 (en) Natural nonwoven materials
BR112012028633A2 (en) reticulated composition and article
FI20115732A0 (en) New cleaner construction
DE112012001239A5 (en) attenuator
DE112012000756A5 (en) attenuator
FR2980364B1 (en) NANOEMULSIONS AND THEIR USE AS CONTRAST AGENTS
BR112013019707A2 (en) anti-nematode methods and compositions
FR2989557B1 (en) NEW FOOD COMPOSITIONS AND THEIR EMBODIMENT
FR2970596B1 (en) CONTACTOR AND SWITCH
ES1073847Y (en) SIMPLIFIED AND LIGHTENED MOTOCULTIVATOR