FR2288749A1 - Procedes pour transformer la niddamycine en leucomycine a1, leucomycine a3, carbomycine b et autres antibiotiques et en o3-esters correspondants et nouveaux composes obtenus par ces procedes - Google Patents
Procedes pour transformer la niddamycine en leucomycine a1, leucomycine a3, carbomycine b et autres antibiotiques et en o3-esters correspondants et nouveaux composes obtenus par ces procedesInfo
- Publication number
- FR2288749A1 FR2288749A1 FR7517321A FR7517321A FR2288749A1 FR 2288749 A1 FR2288749 A1 FR 2288749A1 FR 7517321 A FR7517321 A FR 7517321A FR 7517321 A FR7517321 A FR 7517321A FR 2288749 A1 FR2288749 A1 FR 2288749A1
- Authority
- FR
- France
- Prior art keywords
- leucomycin
- methods
- niddamycin
- carbomycin
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IEMDOFXTVAPVLX-UHFFFAOYSA-N 15-oxo-cleroda-3,13E-dien-18-oic acid Natural products COC1C(O)CC(=O)OC(C)CC=CC=CC(O)C(C)CC(CC=O)C1OC1C(O)C(N(C)C)C(OC2OC(C)C(OC(=O)CC(C)C)C(C)(O)C2)C(C)O1 IEMDOFXTVAPVLX-UHFFFAOYSA-N 0.000 title 1
- IEMDOFXTVAPVLX-YWQHLDGFSA-N Leucomycin A1 Chemical compound CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]2O[C@@H](C)[C@H](OC(=O)CC(C)C)[C@](C)(O)C2)[C@@H](C)O1 IEMDOFXTVAPVLX-YWQHLDGFSA-N 0.000 title 1
- IEMDOFXTVAPVLX-ADNGMUMBSA-N Leucomycin-A1 Natural products CO[C@H]1[C@H](O)CC(=O)O[C@H](C)CC=CC=C[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@@H]([C@H]1O)N(C)C IEMDOFXTVAPVLX-ADNGMUMBSA-N 0.000 title 1
- REPPNUPKOJKPSP-ZZNWINOMSA-N Niddamycin Chemical compound CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\C(=O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]2O[C@@H](C)[C@H](OC(=O)C(C)C)[C@](C)(O)C2)[C@@H](C)O1 REPPNUPKOJKPSP-ZZNWINOMSA-N 0.000 title 1
- PXUIVECFRJIQIG-UHFFFAOYSA-N Niddamycin Natural products COC1C(CC(CC(C)C(=O)C=CC=C/CC(C)OC(=O)CC1OC(=O)C)C=O)OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(C2O)N(C)C PXUIVECFRJIQIG-UHFFFAOYSA-N 0.000 title 1
- ZRNXEMIDBIPJDC-HLPDZUSBSA-N [(2s,3s,4r,6s)-6-[(2r,3s,4r,5r,6s)-6-[[(4r,5s,6s,7r,9r,11e,13e,16r)-4-acetyloxy-5-methoxy-9,16-dimethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3- Chemical compound CO[C@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C\C=C\C=C\C(=O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]2O[C@@H](C)[C@H](OC(=O)CC(C)C)[C@](C)(O)C2)[C@@H](C)O1 ZRNXEMIDBIPJDC-HLPDZUSBSA-N 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- XJSFLOJWULLJQS-NGVXBBESSA-N josamycin Chemical compound CO[C@H]1[C@H](OC(C)=O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]2O[C@@H](C)[C@H](OC(=O)CC(C)C)[C@](C)(O)C2)[C@@H](C)O1 XJSFLOJWULLJQS-NGVXBBESSA-N 0.000 title 1
- 229960004144 josamycin Drugs 0.000 title 1
- XJSFLOJWULLJQS-UHFFFAOYSA-N leucomycin A3 Natural products COC1C(OC(C)=O)CC(=O)OC(C)CC=CC=CC(O)C(C)CC(CC=O)C1OC1C(O)C(N(C)C)C(OC2OC(C)C(OC(=O)CC(C)C)C(C)(O)C2)C(C)O1 XJSFLOJWULLJQS-UHFFFAOYSA-N 0.000 title 1
- 230000001131 transforming effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/476,016 US3970642A (en) | 1974-06-03 | 1974-06-03 | Process for the conversion of niddamycin to leucomycin A1, leucomycin A3, carbomycin B and other antibiotics and related 3-O-esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2288749A1 true FR2288749A1 (fr) | 1976-05-21 |
| FR2288749B1 FR2288749B1 (enExample) | 1979-07-20 |
Family
ID=23890150
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7517321A Granted FR2288749A1 (fr) | 1974-06-03 | 1975-06-03 | Procedes pour transformer la niddamycine en leucomycine a1, leucomycine a3, carbomycine b et autres antibiotiques et en o3-esters correspondants et nouveaux composes obtenus par ces procedes |
| FR7601711A Granted FR2288106A1 (fr) | 1974-06-03 | 1976-01-22 | Procede pour transformer la niddamycine en leucomycine a3 et en o3-esters correspondants, et nouveaux composes et leucomycine a3 obtenus par ce procede |
| FR7601712A Granted FR2288107A1 (fr) | 1974-06-03 | 1976-01-22 | Procede pour transformer la niddamycine en carbomycine b et en o3-esters correspondants, et nouveaux composes et carbomycine b obtenus par ce procede |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7601711A Granted FR2288106A1 (fr) | 1974-06-03 | 1976-01-22 | Procede pour transformer la niddamycine en leucomycine a3 et en o3-esters correspondants, et nouveaux composes et leucomycine a3 obtenus par ce procede |
| FR7601712A Granted FR2288107A1 (fr) | 1974-06-03 | 1976-01-22 | Procede pour transformer la niddamycine en carbomycine b et en o3-esters correspondants, et nouveaux composes et carbomycine b obtenus par ce procede |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3970642A (enExample) |
| JP (1) | JPS514189A (enExample) |
| CA (1) | CA1048019A (enExample) |
| FR (3) | FR2288749A1 (enExample) |
| GB (1) | GB1502791A (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851518A (en) * | 1985-12-23 | 1989-07-25 | Schering Corporation | Di and tri-O-acetyl-"O-iso-valeryl-23-O-demycinosyl tylosins, hydrazone derivatives thereof and processes for their preparation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3792035A (en) * | 1970-05-04 | 1974-02-12 | Meiji Seika Kaisha | Mono-acetyl derivatives of antibiotic sf-837 and sf-837-a2 substances and production thereof |
| US3784447A (en) * | 1972-04-17 | 1974-01-08 | Abbott Lab | Mycarosyl macrolide antibiotics |
| DE2361059A1 (de) * | 1973-12-07 | 1975-07-24 | Hoechst Ag | Verfahren zur herstellung von (androst-17 beta-yl)-alpha-pyronen |
-
1974
- 1974-06-03 US US05/476,016 patent/US3970642A/en not_active Expired - Lifetime
-
1975
- 1975-05-12 GB GB19950/75A patent/GB1502791A/en not_active Expired
- 1975-06-02 JP JP50065458A patent/JPS514189A/ja active Pending
- 1975-06-02 CA CA228,236A patent/CA1048019A/en not_active Expired
- 1975-06-03 FR FR7517321A patent/FR2288749A1/fr active Granted
-
1976
- 1976-01-22 FR FR7601711A patent/FR2288106A1/fr active Granted
- 1976-01-22 FR FR7601712A patent/FR2288107A1/fr active Granted
Non-Patent Citations (3)
| Title |
|---|
| 1750) * |
| JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 75 1953 , PAGES 1749 * |
| ORGANIC REACTIONS IN STEROID CHEMISTRY, VOLUME 1 BY J. FRIED AND I. EDWARDS - VAN NOSTRAND - REINHOLD CO. NEW YORK 1972. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS514189A (enExample) | 1976-01-14 |
| GB1502791A (en) | 1978-03-01 |
| CA1048019A (en) | 1979-02-06 |
| FR2288106A1 (fr) | 1976-05-14 |
| FR2288749B1 (enExample) | 1979-07-20 |
| FR2288107A1 (fr) | 1976-05-14 |
| US3970642A (en) | 1976-07-20 |
| FR2288107B1 (enExample) | 1980-02-22 |
| FR2288106B1 (enExample) | 1979-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |