FR2287222A1 - 2a-Beta,5a-beta-per hydro-2H-furo-(3,4-c)-pyrroles - analgesics some of which have antiinflammatory activity - Google Patents

2a-Beta,5a-beta-per hydro-2H-furo-(3,4-c)-pyrroles - analgesics some of which have antiinflammatory activity

Info

Publication number
FR2287222A1
FR2287222A1 FR7433662A FR7433662A FR2287222A1 FR 2287222 A1 FR2287222 A1 FR 2287222A1 FR 7433662 A FR7433662 A FR 7433662A FR 7433662 A FR7433662 A FR 7433662A FR 2287222 A1 FR2287222 A1 FR 2287222A1
Authority
FR
France
Prior art keywords
beta
substd
opt
analgesics
benzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7433662A
Other languages
French (fr)
Other versions
FR2287222B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeneca Inc
Original Assignee
ICI Americas Inc
ICI United States Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICI Americas Inc, ICI United States Inc filed Critical ICI Americas Inc
Priority to FR7433662A priority Critical patent/FR2287222A1/en
Publication of FR2287222A1 publication Critical patent/FR2287222A1/en
Application granted granted Critical
Publication of FR2287222B1 publication Critical patent/FR2287222B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. of formula (I): where R1 = H, 1-3C alkyl, isobutyl, tert-butyl, 4-8C cycloalkyl, 3-4C alkenyl in which the double bond is sepd. from the N atom by >=1C atom, phenyl, 8-10C phenylalkyl in which the phenyl ring may be halo substd., 2-4C alkanoyl, benzoyl (opt. substd. by =2 haloatoms, methyl or methoxy), 8-10C phenylalkanoyl (the phenyl ring opt. substd. by halo), pyridylcarbonyl or thienylcarbonyl. In the cases where R1 = H, alkyl, cycloalkyl, alkenyl, phenyl, or opt. substd. phenylalkyl the acid addition salts are also claimed. Specif. claimed is (I) where R1 = (4-chlorophenyl)-ethyl, benzoyl, 4-chlorobenzoyl and 3-chlorobenzoyl. (I) are analgesics some of which also have antiinflammatory activity. They are administered orally (unit doses of 50-500 mg), parenterally (0.5-5 wt. % soln.) or rectally opt. with other active cpds., e.g. analgesics, neuroleptics, sedatives or tranquilizers. The maximum sub-lethal dose of I (R1=benzoyl) in rats is 316 mg/kg by intraperitoneal injection and 1000 mg/kg by oral administration.
FR7433662A 1974-10-07 1974-10-07 2a-Beta,5a-beta-per hydro-2H-furo-(3,4-c)-pyrroles - analgesics some of which have antiinflammatory activity Granted FR2287222A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7433662A FR2287222A1 (en) 1974-10-07 1974-10-07 2a-Beta,5a-beta-per hydro-2H-furo-(3,4-c)-pyrroles - analgesics some of which have antiinflammatory activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7433662A FR2287222A1 (en) 1974-10-07 1974-10-07 2a-Beta,5a-beta-per hydro-2H-furo-(3,4-c)-pyrroles - analgesics some of which have antiinflammatory activity

Publications (2)

Publication Number Publication Date
FR2287222A1 true FR2287222A1 (en) 1976-05-07
FR2287222B1 FR2287222B1 (en) 1978-07-21

Family

ID=9143805

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7433662A Granted FR2287222A1 (en) 1974-10-07 1974-10-07 2a-Beta,5a-beta-per hydro-2H-furo-(3,4-c)-pyrroles - analgesics some of which have antiinflammatory activity

Country Status (1)

Country Link
FR (1) FR2287222A1 (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
FR2287222B1 (en) 1978-07-21

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