FR2285873A1 - 4-Oxa or thia spiro (4,5) decane derivs - are CNS stimulants and psychotonics - Google Patents
4-Oxa or thia spiro (4,5) decane derivs - are CNS stimulants and psychotonicsInfo
- Publication number
- FR2285873A1 FR2285873A1 FR7432777A FR7432777A FR2285873A1 FR 2285873 A1 FR2285873 A1 FR 2285873A1 FR 7432777 A FR7432777 A FR 7432777A FR 7432777 A FR7432777 A FR 7432777A FR 2285873 A1 FR2285873 A1 FR 2285873A1
- Authority
- FR
- France
- Prior art keywords
- psychotonics
- derivs
- thia
- oxa
- decane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Title cpds. of formula (I): (where A = O or S, R1,R2 independently = H, lower alkyl or aryl e.g. phenyl and X = H, halo (e.g. Cl or F) or lower alkyl, specif. where a) A = O, R1, R2 = CH3 and X = 4-F, 4-CH3, 3-CH3, 4-Cl and 3-Cl, b) A = O, R1 = CH3, R2 = H and X = 3-CH3, 3-Cl, 4-CH3, 4-F, 4-Cl and H, c) A = O, R1 = phenyl, R2 = H, and X = 3-CH3, 3-Cl or 4-Cl d) A = S, R1 = CH3, R2 = H and X=4-CH3, H, 2-CH3, 3-CH3, 3-Cl and 4-Cl) are CNS stimulants and psychotonics administered e.g. in doses of 25 mg. (I) have low toxicity cf. amphetamines.
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7432777A FR2285873A1 (en) | 1974-09-27 | 1974-09-27 | 4-Oxa or thia spiro (4,5) decane derivs - are CNS stimulants and psychotonics |
BE160236A BE833651A (en) | 1974-09-27 | 1975-09-19 | NEW 6-ARYLOXY-2-OXO-1-AZA-4-OXA (OR THIA) - SPIRO (4,5) DECANES, PROCESS FOR THEIR OBTAINING AND PHARMACEUTICAL APPLICATION |
DE2542154A DE2542154C2 (en) | 1974-09-27 | 1975-09-22 | 6- (3-chloro) phenoxy-3-methyl-2-oxo-1-aza-4-oxa-spiro [4,5] decane, process for its preparation and pharmaceuticals containing it |
CA236,083A CA1051438A (en) | 1974-09-27 | 1975-09-23 | 6-aryloxy-2-oxo-1-aza-4-oxa (or thia)-spiro 4,5 decanes |
US05/616,357 US4000292A (en) | 1974-09-27 | 1975-09-24 | 6-Aryloxy-2-oxo-1-aza-4-oxa (or thia)-spiro[4,5] decanes |
JP50116261A JPS584029B2 (en) | 1974-09-27 | 1975-09-26 | 6-aryloxy-2-oxo-1-aza-4-oxa-(Matahatia)-spiro (4,5) decane |
NLAANVRAGE7511389,A NL183356C (en) | 1974-09-27 | 1975-09-26 | PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION WITH STIMULATING EFFECT ON THE CENTRAL NERVOUS SYSTEM, AND METHOD FOR PREPARING THE USE OF 5-SUBSTITUTED-2-OINOPERATED-OIN-ATERO-PERIATED OIL-ATO-OXYPHYLENE OXYPHANE. |
CH1251375A CH609689A5 (en) | 1974-09-27 | 1975-09-26 | |
ES441289A ES441289A1 (en) | 1974-09-27 | 1975-09-26 | 6-aryloxy-2-oxo-1-aza-4-oxa (or thia)-spiro(4,5)+0 decanes |
AT737075A AT346325B (en) | 1974-09-27 | 1975-09-26 | PROCESS FOR PRODUCING NEW THIAZOLIDONE OR OXAZOLIDONE DERIVATIVES |
GB39548/75A GB1500826A (en) | 1974-09-27 | 1975-09-26 | Spiro compounds and their use in pharmaceutical compositions |
MX280775U MX3045E (en) | 1974-09-27 | 1975-09-29 | PROCEDURE FOR OBTAINING 6 - ARIL OXI - 2 - OXO - 1 - AZA - 4 - OXA (or TIA) - SPIRO [4, 5] DECANS |
US05/717,716 US4086352A (en) | 1974-09-27 | 1976-08-25 | Certain 6-aryloxy-2-oxo-1-aza-4-thia-spiro[4,5]decanes |
US05/843,086 USRE29902E (en) | 1974-09-27 | 1977-10-17 | 6-Aryloxy-2-oxo-1-aza-4-oxo (or thia)-spiro[4,5]decanes as CNS stimulants |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7432777A FR2285873A1 (en) | 1974-09-27 | 1974-09-27 | 4-Oxa or thia spiro (4,5) decane derivs - are CNS stimulants and psychotonics |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2285873A1 true FR2285873A1 (en) | 1976-04-23 |
FR2285873B1 FR2285873B1 (en) | 1978-07-21 |
Family
ID=9143541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7432777A Granted FR2285873A1 (en) | 1974-09-27 | 1974-09-27 | 4-Oxa or thia spiro (4,5) decane derivs - are CNS stimulants and psychotonics |
Country Status (3)
Country | Link |
---|---|
AT (1) | AT346325B (en) |
BE (1) | BE833651A (en) |
FR (1) | FR2285873A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2612398A1 (en) * | 1987-03-18 | 1988-09-23 | Cerm Cent Europ Rech Mauvernay | Pharmaceutical composition containing a combination of 6-(3-chlorophenoxy)-2-methyl-1-oxa-4-azaspiro[4.5]decan-3-one and beta -cyclodextrin |
-
1974
- 1974-09-27 FR FR7432777A patent/FR2285873A1/en active Granted
-
1975
- 1975-09-19 BE BE160236A patent/BE833651A/en not_active IP Right Cessation
- 1975-09-26 AT AT737075A patent/AT346325B/en not_active IP Right Cessation
Non-Patent Citations (1)
Title |
---|
JOURNAL OF MEDICINAL CHEMISTRY 8, PAGES 95 - 100 1965 CITE PAR LA DEMANDERESSE ) * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2612398A1 (en) * | 1987-03-18 | 1988-09-23 | Cerm Cent Europ Rech Mauvernay | Pharmaceutical composition containing a combination of 6-(3-chlorophenoxy)-2-methyl-1-oxa-4-azaspiro[4.5]decan-3-one and beta -cyclodextrin |
Also Published As
Publication number | Publication date |
---|---|
FR2285873B1 (en) | 1978-07-21 |
AT346325B (en) | 1978-11-10 |
ATA737075A (en) | 1978-03-15 |
BE833651A (en) | 1976-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CD | Change of name or company name | ||
ST | Notification of lapse |