FR2279384A1 - Tetrahydro-5,10-methane-(5H)-bicyclononene-12-amines - used as inters for analgesic 6,7,8,9,10,11-hexahydro cpds - Google Patents

Tetrahydro-5,10-methane-(5H)-bicyclononene-12-amines - used as inters for analgesic 6,7,8,9,10,11-hexahydro cpds

Info

Publication number
FR2279384A1
FR2279384A1 FR7434504A FR7434504A FR2279384A1 FR 2279384 A1 FR2279384 A1 FR 2279384A1 FR 7434504 A FR7434504 A FR 7434504A FR 7434504 A FR7434504 A FR 7434504A FR 2279384 A1 FR2279384 A1 FR 2279384A1
Authority
FR
France
Prior art keywords
cpds
bicyclononene
inters
hexahydro
analgesic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7434504A
Other languages
French (fr)
Other versions
FR2279384B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of FR2279384A1 publication Critical patent/FR2279384A1/en
Application granted granted Critical
Publication of FR2279384B1 publication Critical patent/FR2279384B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds. of formula (I) (where R is H, lower alkyl, or phenyl-lower alkyl, R' is CH3, C2H5 or lower alkenyl, and R2 and R3 are each H, lower alkyl, lower alkenyl, lower alkynyl or phenyl-lower alkyl) may be reduced by catalytic hydrogenation to cpds. of formula (III) which are analgesics.
FR7434504A 1973-10-15 1974-10-14 Tetrahydro-5,10-methane-(5H)-bicyclononene-12-amines - used as inters for analgesic 6,7,8,9,10,11-hexahydro cpds Granted FR2279384A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40652173A 1973-10-15 1973-10-15
GB1141074 1974-03-14

Publications (2)

Publication Number Publication Date
FR2279384A1 true FR2279384A1 (en) 1976-02-20
FR2279384B1 FR2279384B1 (en) 1978-07-21

Family

ID=26248260

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7434504A Granted FR2279384A1 (en) 1973-10-15 1974-10-14 Tetrahydro-5,10-methane-(5H)-bicyclononene-12-amines - used as inters for analgesic 6,7,8,9,10,11-hexahydro cpds

Country Status (5)

Country Link
JP (2) JPS5537988B2 (en)
CA (1) CA1055527A (en)
CH (1) CH617664A5 (en)
FR (1) FR2279384A1 (en)
NL (1) NL7413487A (en)

Also Published As

Publication number Publication date
JPS5537988B2 (en) 1980-10-01
CH617664A5 (en) 1980-06-13
JPS5439062A (en) 1979-03-24
JPS5811420B2 (en) 1983-03-02
CA1055527A (en) 1979-05-29
NL7413487A (en) 1975-04-17
FR2279384B1 (en) 1978-07-21
JPS5064256A (en) 1975-05-31

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