FR2278327A2 - 4-(3-Benzoylphenyl)-butanols and butenols - with antiinflammatory and analgesic activity - Google Patents

4-(3-Benzoylphenyl)-butanols and butenols - with antiinflammatory and analgesic activity

Info

Publication number
FR2278327A2
FR2278327A2 FR7425165A FR7425165A FR2278327A2 FR 2278327 A2 FR2278327 A2 FR 2278327A2 FR 7425165 A FR7425165 A FR 7425165A FR 7425165 A FR7425165 A FR 7425165A FR 2278327 A2 FR2278327 A2 FR 2278327A2
Authority
FR
France
Prior art keywords
butenols
benzoylphenyl
butanols
antiinflammatory
analgesic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7425165A
Other languages
French (fr)
Other versions
FR2278327B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7425165A priority Critical patent/FR2278327A2/en
Publication of FR2278327A2 publication Critical patent/FR2278327A2/en
Application granted granted Critical
Publication of FR2278327B2 publication Critical patent/FR2278327B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

4-(3-Benzoylphenyl)butanols and butenols of formula (I) and their esters (where X1 -4 are H halo, 1-5C alkyl 1-5C alkoxy, 1-5C alkylthio, OCF3, -SCF3, CF3, OH or di-(1-5C alkyl amino; and Z and X are H or 1-5c alkyl), have analgesic antiinflammatory and antirheumatic activity.
FR7425165A 1974-07-19 1974-07-19 4-(3-Benzoylphenyl)-butanols and butenols - with antiinflammatory and analgesic activity Granted FR2278327A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7425165A FR2278327A2 (en) 1974-07-19 1974-07-19 4-(3-Benzoylphenyl)-butanols and butenols - with antiinflammatory and analgesic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7425165A FR2278327A2 (en) 1974-07-19 1974-07-19 4-(3-Benzoylphenyl)-butanols and butenols - with antiinflammatory and analgesic activity

Publications (2)

Publication Number Publication Date
FR2278327A2 true FR2278327A2 (en) 1976-02-13
FR2278327B2 FR2278327B2 (en) 1978-09-22

Family

ID=9141485

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7425165A Granted FR2278327A2 (en) 1974-07-19 1974-07-19 4-(3-Benzoylphenyl)-butanols and butenols - with antiinflammatory and analgesic activity

Country Status (1)

Country Link
FR (1) FR2278327A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052599A2 (en) * 1979-02-07 1982-05-26 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Propargyl derivatives and their preparation
WO1986005777A1 (en) * 1985-04-03 1986-10-09 MERCK Patent Gesellschaft mit beschränkter Haftung Photo-initiator for the photo-polymerization of unsaturated systems

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052599A2 (en) * 1979-02-07 1982-05-26 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Propargyl derivatives and their preparation
EP0052599A3 (en) * 1979-02-07 1982-08-11 F. Hoffmann-La Roche & Co. Aktiengesellschaft Propargyl derivatives and their preparation
WO1986005777A1 (en) * 1985-04-03 1986-10-09 MERCK Patent Gesellschaft mit beschränkter Haftung Photo-initiator for the photo-polymerization of unsaturated systems
WO1986005778A1 (en) * 1985-04-03 1986-10-09 MERCK Patent Gesellschaft mit beschränkter Haftung Photo-initiators for photo-polymerization of unsaturated systems

Also Published As

Publication number Publication date
FR2278327B2 (en) 1978-09-22

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