FR2276824A1 - Derives de la piperazine 1,4-disubstituee, leur procede de preparation et leurs applications therapeutiques - Google Patents
Derives de la piperazine 1,4-disubstituee, leur procede de preparation et leurs applications therapeutiquesInfo
- Publication number
- FR2276824A1 FR2276824A1 FR7423262A FR7423262A FR2276824A1 FR 2276824 A1 FR2276824 A1 FR 2276824A1 FR 7423262 A FR7423262 A FR 7423262A FR 7423262 A FR7423262 A FR 7423262A FR 2276824 A1 FR2276824 A1 FR 2276824A1
- Authority
- FR
- France
- Prior art keywords
- propionyl
- codeine
- benzhydryloxymethyl
- piperazines
- good
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 title abstract 4
- 230000000954 anitussive effect Effects 0.000 title abstract 2
- 229960004126 codeine Drugs 0.000 title abstract 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 title abstract 2
- PCCYYQOTVGBKOF-UHFFFAOYSA-N 1-[1-(benzhydryloxymethyl)piperazin-2-yl]propan-1-one Chemical class C(CC)(=O)C1N(CCNC1)COC(C1=CC=CC=C1)C1=CC=CC=C1 PCCYYQOTVGBKOF-UHFFFAOYSA-N 0.000 title 1
- MBFDHHKTIBKZNR-UHFFFAOYSA-N 1-(2-benzhydryloxyethyl)piperazine Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)OCCN1CCNCC1 MBFDHHKTIBKZNR-UHFFFAOYSA-N 0.000 abstract 1
- ISHMWTYDIQTXFE-UHFFFAOYSA-N 1-[4-(2-benzhydryloxyethyl)piperazin-1-yl]propan-1-one Chemical compound C(CC)(=O)N1CCN(CC1)CCOC(C1=CC=CC=C1)C1=CC=CC=C1 ISHMWTYDIQTXFE-UHFFFAOYSA-N 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 abstract 1
- 230000000994 depressogenic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7423262A FR2276824A1 (fr) | 1974-07-04 | 1974-07-04 | Derives de la piperazine 1,4-disubstituee, leur procede de preparation et leurs applications therapeutiques |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7423262A FR2276824A1 (fr) | 1974-07-04 | 1974-07-04 | Derives de la piperazine 1,4-disubstituee, leur procede de preparation et leurs applications therapeutiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2276824A1 true FR2276824A1 (fr) | 1976-01-30 |
| FR2276824B1 FR2276824B1 (OSRAM) | 1978-07-21 |
Family
ID=9140880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7423262A Granted FR2276824A1 (fr) | 1974-07-04 | 1974-07-04 | Derives de la piperazine 1,4-disubstituee, leur procede de preparation et leurs applications therapeutiques |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2276824A1 (OSRAM) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601366A1 (fr) * | 1986-07-10 | 1988-01-15 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
| US4874765A (en) * | 1986-04-22 | 1989-10-17 | Richter Gedeon Vegyeszeti Gyar | 1,4-Disubstituted piperazines having dopaminergic activity |
| EP0259227B1 (fr) * | 1986-09-05 | 1991-12-27 | Société anonyme: LES LABORATOIRES MERAM | Dérivés de la benzhydryloxyéthyl-pipéridine, procédé d'obtention et compositions pharmaceutiques les contenant |
| WO1992001679A1 (en) * | 1990-07-26 | 1992-02-06 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
| US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
-
1974
- 1974-07-04 FR FR7423262A patent/FR2276824A1/fr active Granted
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4874765A (en) * | 1986-04-22 | 1989-10-17 | Richter Gedeon Vegyeszeti Gyar | 1,4-Disubstituted piperazines having dopaminergic activity |
| AU599100B2 (en) * | 1986-04-28 | 1990-07-12 | Richter Gedeon Vegyeszeti Gyar Rt. | 1,4-disubstituted piperazine derivatives, pharmaceutical compositions containing them and process for preparing same |
| FR2601366A1 (fr) * | 1986-07-10 | 1988-01-15 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
| EP0254627A1 (fr) * | 1986-07-10 | 1988-01-27 | Société anonyme: LES LABORATOIRES MERAM | Dérivés de la benzhydryloxyéthylpipérazine, procédés d'obtention et compositions pharmaceutiques les contenant |
| US4908365A (en) * | 1986-07-10 | 1990-03-13 | Andre Buzas | Benzhydryloxyethylpiperazine derivatives, processes for their preparation and pharmaceutical compositions in which they are present |
| EP0259227B1 (fr) * | 1986-09-05 | 1991-12-27 | Société anonyme: LES LABORATOIRES MERAM | Dérivés de la benzhydryloxyéthyl-pipéridine, procédé d'obtention et compositions pharmaceutiques les contenant |
| WO1992001679A1 (en) * | 1990-07-26 | 1992-02-06 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
| US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
| AU665172B2 (en) * | 1990-07-26 | 1995-12-21 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2276824B1 (OSRAM) | 1978-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| ST | Notification of lapse |