FR2276060A1 - Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility - Google Patents
Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragilityInfo
- Publication number
- FR2276060A1 FR2276060A1 FR7422371A FR7422371A FR2276060A1 FR 2276060 A1 FR2276060 A1 FR 2276060A1 FR 7422371 A FR7422371 A FR 7422371A FR 7422371 A FR7422371 A FR 7422371A FR 2276060 A1 FR2276060 A1 FR 2276060A1
- Authority
- FR
- France
- Prior art keywords
- flavonoids
- solvent
- chrysnthellum
- prepd
- chrysanthellum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/40—Separation, e.g. from natural material; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
New flavonoid compsns. are obtd. from varieties of Chrysanthellum, esp. Chrysanthellum procumbens Rich and are capillary protectors, useful in the treatment of fragility of the vascular wall, and such conditions as haemorrhoids, oedema, purpura, arterial hypertension, hepatic insufficiency, diabetes, etc. The compsn. are extracted from the plant by boiling water and extracted into ethyl acetate. The organic phase is evaporated and the residue taken up into water. After filtering the aqs. phase is concentrated and a solvent such as methanol is added. The flavonoids are then pptd. by addition of a solvent in which they are insoluble such as chloroform, petroleum ether, or methylene chloride. In toxicity tests the compsns. had LD50 =>9600 mg/kg p.o. (mouse); and >400 mg/kg i.v. (mouse). Oral and intraperitoneal administration of 200 mg/kg and 500 mg/kg per day for 6 weeks to rats caused no mortality or adverse effects.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7422371A FR2276060A1 (en) | 1974-06-27 | 1974-06-27 | Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7422371A FR2276060A1 (en) | 1974-06-27 | 1974-06-27 | Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2276060A1 true FR2276060A1 (en) | 1976-01-23 |
FR2276060B1 FR2276060B1 (en) | 1978-07-21 |
Family
ID=9140576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7422371A Granted FR2276060A1 (en) | 1974-06-27 | 1974-06-27 | Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2276060A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2801186A1 (en) * | 1977-01-20 | 1978-07-27 | Sarget Lab | VEGETABLE EXTRACT OF CHRYSANTELLUM SPECIES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE EXTRACT |
FR2579907A1 (en) * | 1985-04-09 | 1986-10-10 | Couderc Pierre | Method for enriching chrysantellum with active ingredients by physical processes |
FR2618071A1 (en) * | 1987-07-17 | 1989-01-20 | Guillot Bernard | Cosmetic and dermatological compositions based on chrysanthellum extracts |
EP0317453A1 (en) * | 1987-11-19 | 1989-05-24 | IPHYM SA Société Anonyme dite : | Medicinal compositions based on flavonoids and saponins extracted from chrysanthellum, process for their manufacture and therapeutical uses |
FR2643073A1 (en) * | 1989-02-15 | 1990-08-17 | Expansion Rech Phytochimie | PROCESS FOR THE PREPARATION OF PURIFIED FLAVAN-3-OL POLYPHENOLIC EXTRACTS AND EXTRACTS OBTAINED |
FR2842109A1 (en) * | 2002-07-11 | 2004-01-16 | Sicobel Lab | USE OF A CHRYSANTHELLUM EXTRACT |
EP0907353B1 (en) * | 1997-01-09 | 2004-02-11 | Lanatech Laboratoire Nature Et Technique | Slimming cosmetic composition containing a chrysanthellum indicum extract |
-
1974
- 1974-06-27 FR FR7422371A patent/FR2276060A1/en active Granted
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2801186A1 (en) * | 1977-01-20 | 1978-07-27 | Sarget Lab | VEGETABLE EXTRACT OF CHRYSANTELLUM SPECIES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE EXTRACT |
FR2579907A1 (en) * | 1985-04-09 | 1986-10-10 | Couderc Pierre | Method for enriching chrysantellum with active ingredients by physical processes |
FR2618071A1 (en) * | 1987-07-17 | 1989-01-20 | Guillot Bernard | Cosmetic and dermatological compositions based on chrysanthellum extracts |
EP0317453A1 (en) * | 1987-11-19 | 1989-05-24 | IPHYM SA Société Anonyme dite : | Medicinal compositions based on flavonoids and saponins extracted from chrysanthellum, process for their manufacture and therapeutical uses |
FR2623398A1 (en) * | 1987-11-19 | 1989-05-26 | Iphym Sa | MEDICINAL COMPOSITIONS BASED ON FLAVONOIDS AND SAPONINS EXTRACTED FROM CHRYSANTHELLUM. PROCESS FOR PREPARATION AND THERAPEUTIC APPLICATIONS |
FR2643073A1 (en) * | 1989-02-15 | 1990-08-17 | Expansion Rech Phytochimie | PROCESS FOR THE PREPARATION OF PURIFIED FLAVAN-3-OL POLYPHENOLIC EXTRACTS AND EXTRACTS OBTAINED |
EP0384796A1 (en) * | 1989-02-15 | 1990-08-29 | Societe Civile Pour L' Expansion De La Recherche En Phytochimie Appliquee | Method of preparing purified polyphenolic flavan-3-ol type extracts and extracts obtained thereby |
EP0907353B1 (en) * | 1997-01-09 | 2004-02-11 | Lanatech Laboratoire Nature Et Technique | Slimming cosmetic composition containing a chrysanthellum indicum extract |
FR2842109A1 (en) * | 2002-07-11 | 2004-01-16 | Sicobel Lab | USE OF A CHRYSANTHELLUM EXTRACT |
WO2004006943A2 (en) * | 2002-07-11 | 2004-01-22 | Laboratoire Sicobel | Use of a chrysanthellum extract |
WO2004006943A3 (en) * | 2002-07-11 | 2004-04-08 | Sicobel Lab | Use of a chrysanthellum extract |
Also Published As
Publication number | Publication date |
---|---|
FR2276060B1 (en) | 1978-07-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO951281D0 (en) | Process for the preparation of 10-desacetyl-baccatin-III | |
FR2276060A1 (en) | Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility | |
ES466222A1 (en) | Chrysanthellum plant extract | |
Kaneta et al. | The Constituents of Arthraxon hispidus Makino, Miscanthus tinctorius Hackel, Miscanthus sinensis Anderss, and Phragmites communis Trinius | |
JPS6461482A (en) | Dehydrocamptothecin and production thereof | |
JPS5282710A (en) | Extraction of effective drug component from mulberry | |
US2460240A (en) | Resolution of racemic alpha hydroxy beta, beta dimethyl gamma butyrolactone | |
NO135419B (en) | ||
JPS5711986A (en) | Okadaic acid, its salt, and its ester | |
Braithwaite et al. | 48. The action of hydrogen sulphide on certain methyleneimines. Part I | |
SU1666457A1 (en) | Method for obtaining pectin | |
JPS52139711A (en) | Extraction of solanesole | |
NORDAL et al. | The non-volatile acids of succulent plants exhibiting a marked di-urnal oscillation in their acid content | |
JPS5437096A (en) | Method of procucing pure phosphoric acid | |
JPS55159796A (en) | Mass-production of carcinostatic from sclerotium of polyporus umbellatus fr. | |
JPS5210214A (en) | Process for recovery of methylmethacrylate dimer | |
GB857128A (en) | Production of alpha-hydroxy-beta, beta-dimethyl-gamma-butyrolactone | |
NO123928B (en) | ||
SU457199A3 (en) | The method of obtaining a drug having a laxative effect | |
US2887489A (en) | Process and intermediate for | |
SU322049A1 (en) | WAY OF OBTAINING 17a-ACETATE 3-METHYL ETHER | |
JPS5419985A (en) | Production of hydroxycarbostyril derivative | |
US1987743A (en) | Compounds of primula saponine | |
JPS5412369A (en) | Preparation of thienylacetic acid | |
IL24061A (en) | Process for the preparation of substituted gamma-lactones and products resulting from this process |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse | ||
AR | Application made for restoration | ||
BR | Restoration of rights | ||
CD | Change of name or company name | ||
TP | Transmission of property |