FR2276060A1 - Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility - Google Patents

Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility

Info

Publication number
FR2276060A1
FR2276060A1 FR7422371A FR7422371A FR2276060A1 FR 2276060 A1 FR2276060 A1 FR 2276060A1 FR 7422371 A FR7422371 A FR 7422371A FR 7422371 A FR7422371 A FR 7422371A FR 2276060 A1 FR2276060 A1 FR 2276060A1
Authority
FR
France
Prior art keywords
flavonoids
solvent
chrysnthellum
prepd
chrysanthellum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7422371A
Other languages
French (fr)
Other versions
FR2276060B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cortial SA
Original Assignee
Cortial SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortial SA filed Critical Cortial SA
Priority to FR7422371A priority Critical patent/FR2276060A1/en
Publication of FR2276060A1 publication Critical patent/FR2276060A1/en
Application granted granted Critical
Publication of FR2276060B1 publication Critical patent/FR2276060B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/40—Separation, e.g. from natural material; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

New flavonoid compsns. are obtd. from varieties of Chrysanthellum, esp. Chrysanthellum procumbens Rich and are capillary protectors, useful in the treatment of fragility of the vascular wall, and such conditions as haemorrhoids, oedema, purpura, arterial hypertension, hepatic insufficiency, diabetes, etc. The compsn. are extracted from the plant by boiling water and extracted into ethyl acetate. The organic phase is evaporated and the residue taken up into water. After filtering the aqs. phase is concentrated and a solvent such as methanol is added. The flavonoids are then pptd. by addition of a solvent in which they are insoluble such as chloroform, petroleum ether, or methylene chloride. In toxicity tests the compsns. had LD50 =>9600 mg/kg p.o. (mouse); and >400 mg/kg i.v. (mouse). Oral and intraperitoneal administration of 200 mg/kg and 500 mg/kg per day for 6 weeks to rats caused no mortality or adverse effects.
FR7422371A 1974-06-27 1974-06-27 Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility Granted FR2276060A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7422371A FR2276060A1 (en) 1974-06-27 1974-06-27 Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7422371A FR2276060A1 (en) 1974-06-27 1974-06-27 Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility

Publications (2)

Publication Number Publication Date
FR2276060A1 true FR2276060A1 (en) 1976-01-23
FR2276060B1 FR2276060B1 (en) 1978-07-21

Family

ID=9140576

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7422371A Granted FR2276060A1 (en) 1974-06-27 1974-06-27 Flavonoids from chrysnthellum - prepd by aqueous extraction and solvent precipitation- for treating capillary fragility

Country Status (1)

Country Link
FR (1) FR2276060A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2801186A1 (en) * 1977-01-20 1978-07-27 Sarget Lab VEGETABLE EXTRACT OF CHRYSANTELLUM SPECIES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE EXTRACT
FR2579907A1 (en) * 1985-04-09 1986-10-10 Couderc Pierre Method for enriching chrysantellum with active ingredients by physical processes
FR2618071A1 (en) * 1987-07-17 1989-01-20 Guillot Bernard Cosmetic and dermatological compositions based on chrysanthellum extracts
EP0317453A1 (en) * 1987-11-19 1989-05-24 IPHYM SA Société Anonyme dite : Medicinal compositions based on flavonoids and saponins extracted from chrysanthellum, process for their manufacture and therapeutical uses
FR2643073A1 (en) * 1989-02-15 1990-08-17 Expansion Rech Phytochimie PROCESS FOR THE PREPARATION OF PURIFIED FLAVAN-3-OL POLYPHENOLIC EXTRACTS AND EXTRACTS OBTAINED
FR2842109A1 (en) * 2002-07-11 2004-01-16 Sicobel Lab USE OF A CHRYSANTHELLUM EXTRACT
EP0907353B1 (en) * 1997-01-09 2004-02-11 Lanatech Laboratoire Nature Et Technique Slimming cosmetic composition containing a chrysanthellum indicum extract

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2801186A1 (en) * 1977-01-20 1978-07-27 Sarget Lab VEGETABLE EXTRACT OF CHRYSANTELLUM SPECIES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE EXTRACT
FR2579907A1 (en) * 1985-04-09 1986-10-10 Couderc Pierre Method for enriching chrysantellum with active ingredients by physical processes
FR2618071A1 (en) * 1987-07-17 1989-01-20 Guillot Bernard Cosmetic and dermatological compositions based on chrysanthellum extracts
EP0317453A1 (en) * 1987-11-19 1989-05-24 IPHYM SA Société Anonyme dite : Medicinal compositions based on flavonoids and saponins extracted from chrysanthellum, process for their manufacture and therapeutical uses
FR2623398A1 (en) * 1987-11-19 1989-05-26 Iphym Sa MEDICINAL COMPOSITIONS BASED ON FLAVONOIDS AND SAPONINS EXTRACTED FROM CHRYSANTHELLUM. PROCESS FOR PREPARATION AND THERAPEUTIC APPLICATIONS
FR2643073A1 (en) * 1989-02-15 1990-08-17 Expansion Rech Phytochimie PROCESS FOR THE PREPARATION OF PURIFIED FLAVAN-3-OL POLYPHENOLIC EXTRACTS AND EXTRACTS OBTAINED
EP0384796A1 (en) * 1989-02-15 1990-08-29 Societe Civile Pour L' Expansion De La Recherche En Phytochimie Appliquee Method of preparing purified polyphenolic flavan-3-ol type extracts and extracts obtained thereby
EP0907353B1 (en) * 1997-01-09 2004-02-11 Lanatech Laboratoire Nature Et Technique Slimming cosmetic composition containing a chrysanthellum indicum extract
FR2842109A1 (en) * 2002-07-11 2004-01-16 Sicobel Lab USE OF A CHRYSANTHELLUM EXTRACT
WO2004006943A2 (en) * 2002-07-11 2004-01-22 Laboratoire Sicobel Use of a chrysanthellum extract
WO2004006943A3 (en) * 2002-07-11 2004-04-08 Sicobel Lab Use of a chrysanthellum extract

Also Published As

Publication number Publication date
FR2276060B1 (en) 1978-07-21

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse
AR Application made for restoration
BR Restoration of rights
CD Change of name or company name
TP Transmission of property