FR2273532A1 - Nouveaux derives du thienyl-2 acetonitrile, leurs sels, leur preparation et les medicaments qui en contiennent - Google Patents
Nouveaux derives du thienyl-2 acetonitrile, leurs sels, leur preparation et les medicaments qui en contiennentInfo
- Publication number
- FR2273532A1 FR2273532A1 FR7419476A FR7419476A FR2273532A1 FR 2273532 A1 FR2273532 A1 FR 2273532A1 FR 7419476 A FR7419476 A FR 7419476A FR 7419476 A FR7419476 A FR 7419476A FR 2273532 A1 FR2273532 A1 FR 2273532A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- opt
- esp
- halo
- thienylacetonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002048 spasmolytic effect Effects 0.000 title abstract 3
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 title 2
- 229930008281 A03AD01 - Papaverine Natural products 0.000 title 1
- 229960001789 papaverine Drugs 0.000 title 1
- 229940124549 vasodilator Drugs 0.000 title 1
- 239000003071 vasodilator agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- -1 alpha-hydroxybenzyl Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- UOTMYNBWXDUBNX-UHFFFAOYSA-N 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinolin-2-ium;chloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 UOTMYNBWXDUBNX-UHFFFAOYSA-N 0.000 abstract 1
- CLSHQIDDCJTHAJ-UHFFFAOYSA-N 2-thienylacetonitrile Chemical compound N#CCC1=CC=CS1 CLSHQIDDCJTHAJ-UHFFFAOYSA-N 0.000 abstract 1
- 241000700199 Cavia porcellus Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 210000003405 ileum Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229960003207 papaverine hydrochloride Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7419476A FR2273532A1 (fr) | 1974-06-06 | 1974-06-06 | Nouveaux derives du thienyl-2 acetonitrile, leurs sels, leur preparation et les medicaments qui en contiennent |
| BE157061A BE829913A (fr) | 1974-06-06 | 1975-06-05 | Nouveaux derives du thienyl-2-acetonitrile |
| JP6902275A JPS51125070A (en) | 1974-06-06 | 1975-06-06 | Production of 22 thienylacetonitrile derivatives |
| ES438290A ES438290A1 (es) | 1974-06-06 | 1975-06-06 | Procedimiento para preparar derivados de tienil-2 acetoni- trilo. |
| DE19752525319 DE2525319A1 (de) | 1974-06-06 | 1975-06-06 | Neue derivate von thienyl-2-acetonitril |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7419476A FR2273532A1 (fr) | 1974-06-06 | 1974-06-06 | Nouveaux derives du thienyl-2 acetonitrile, leurs sels, leur preparation et les medicaments qui en contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2273532A1 true FR2273532A1 (fr) | 1976-01-02 |
| FR2273532B1 FR2273532B1 (esLanguage) | 1978-06-30 |
Family
ID=9139682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7419476A Granted FR2273532A1 (fr) | 1974-06-06 | 1974-06-06 | Nouveaux derives du thienyl-2 acetonitrile, leurs sels, leur preparation et les medicaments qui en contiennent |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE829913A (esLanguage) |
| FR (1) | FR2273532A1 (esLanguage) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783537A (en) * | 1985-11-13 | 1988-11-08 | Pennwalt Corporation | α-(aminoalkyl)-arylacetic acid derivatives |
| US4847301A (en) * | 1985-11-13 | 1989-07-11 | Pennwalt Corporation | Methods of use of α-(aminoalkyl)-arylacetic acid derivatives |
| EP0330940A3 (de) * | 1988-02-27 | 1990-10-31 | Roche Diagnostics GmbH | Neue trisubstituierte Amine, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten |
-
1974
- 1974-06-06 FR FR7419476A patent/FR2273532A1/fr active Granted
-
1975
- 1975-06-05 BE BE157061A patent/BE829913A/xx unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783537A (en) * | 1985-11-13 | 1988-11-08 | Pennwalt Corporation | α-(aminoalkyl)-arylacetic acid derivatives |
| US4847301A (en) * | 1985-11-13 | 1989-07-11 | Pennwalt Corporation | Methods of use of α-(aminoalkyl)-arylacetic acid derivatives |
| EP0330940A3 (de) * | 1988-02-27 | 1990-10-31 | Roche Diagnostics GmbH | Neue trisubstituierte Amine, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2273532B1 (esLanguage) | 1978-06-30 |
| BE829913A (fr) | 1975-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |