FR2268016A1 - Racemic or opt. active eburnamonines - by reaction of racemic or opt. active vincamines, in an organic solven, with a base - Google Patents

Racemic or opt. active eburnamonines - by reaction of racemic or opt. active vincamines, in an organic solven, with a base

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Publication number
FR2268016A1
FR2268016A1 FR7413351A FR7413351A FR2268016A1 FR 2268016 A1 FR2268016 A1 FR 2268016A1 FR 7413351 A FR7413351 A FR 7413351A FR 7413351 A FR7413351 A FR 7413351A FR 2268016 A1 FR2268016 A1 FR 2268016A1
Authority
FR
France
Prior art keywords
racemic
opt
active
eburnamonines
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7413351A
Other languages
French (fr)
Other versions
FR2268016B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnium Chimique SA
Original Assignee
Omnium Chimique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnium Chimique SA filed Critical Omnium Chimique SA
Priority to FR7413351A priority Critical patent/FR2268016A1/en
Publication of FR2268016A1 publication Critical patent/FR2268016A1/en
Application granted granted Critical
Publication of FR2268016B1 publication Critical patent/FR2268016B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A new prepn. of (I)-, (+) (-)-eburnamonines by reaction of (plus-or-minus)-, (+)- or (-)- vincamines, dissolved in an organic solvent, with a base. Increased yields of optically active and racemic eburnamonines, used in treatment of cerebral vascular disorders. Synthesis of the (+)-isomer has not been described before. Suitable solvents are aliphatic or aromatic hydrocarbons, alkanols e.g. t-butanol, and their mixts. Pref. bases are sodium or potassium alkoxides. Optical isomers are not racemized by the conditions of the reaction.
FR7413351A 1974-04-17 1974-04-17 Racemic or opt. active eburnamonines - by reaction of racemic or opt. active vincamines, in an organic solven, with a base Granted FR2268016A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7413351A FR2268016A1 (en) 1974-04-17 1974-04-17 Racemic or opt. active eburnamonines - by reaction of racemic or opt. active vincamines, in an organic solven, with a base

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7413351A FR2268016A1 (en) 1974-04-17 1974-04-17 Racemic or opt. active eburnamonines - by reaction of racemic or opt. active vincamines, in an organic solven, with a base

Publications (2)

Publication Number Publication Date
FR2268016A1 true FR2268016A1 (en) 1975-11-14
FR2268016B1 FR2268016B1 (en) 1976-12-17

Family

ID=9137723

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7413351A Granted FR2268016A1 (en) 1974-04-17 1974-04-17 Racemic or opt. active eburnamonines - by reaction of racemic or opt. active vincamines, in an organic solven, with a base

Country Status (1)

Country Link
FR (1) FR2268016A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3322686A1 (en) * 1982-06-30 1984-02-16 Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest NEW EBURNE DERIVATIVES, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3409185A1 (en) * 1984-04-12 1985-09-26 Consiglio Nazionale Delle Ricerche, Rom/Roma Process for the preparation of eburnamonines by electrochemical means

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3322686A1 (en) * 1982-06-30 1984-02-16 Richter Gedeon Vegyészeti Gyár R.T., 1475 Budapest NEW EBURNE DERIVATIVES, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3409185A1 (en) * 1984-04-12 1985-09-26 Consiglio Nazionale Delle Ricerche, Rom/Roma Process for the preparation of eburnamonines by electrochemical means
FR2562894A1 (en) * 1984-04-12 1985-10-18 Consiglio Nazionale Ricerche Eburnamonine prepn. by electrolysis of vincaminic acid

Also Published As

Publication number Publication date
FR2268016B1 (en) 1976-12-17

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