FR2262512A1 - 2,4,6-Tri-substd. -1,3,5-triazines - with analgesic and psychotropic activity - Google Patents

2,4,6-Tri-substd. -1,3,5-triazines - with analgesic and psychotropic activity

Info

Publication number
FR2262512A1
FR2262512A1 FR7406964A FR7406964A FR2262512A1 FR 2262512 A1 FR2262512 A1 FR 2262512A1 FR 7406964 A FR7406964 A FR 7406964A FR 7406964 A FR7406964 A FR 7406964A FR 2262512 A1 FR2262512 A1 FR 2262512A1
Authority
FR
France
Prior art keywords
opt
alkyl
substd
unsatd
mono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7406964A
Other languages
French (fr)
Other versions
FR2262512B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7406964A priority Critical patent/FR2262512A1/en
Publication of FR2262512A1 publication Critical patent/FR2262512A1/en
Application granted granted Critical
Publication of FR2262512B1 publication Critical patent/FR2262512B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1, 3, 5-Triazines of formula (I) and their acid-addn. salts (where R' is 1-5C alkyl, opt. unsatd. and opt. substd. by one or more halogens; opt. substd. phenyl; Y is NH2, the gp. NHR2 R2 is 1-5C alkyl, opt. unsatd. or where n is 2 or 3; the chain (CH2)n is opt. substd. by 1-5C alkyl, opt. unsatd. R3 and R4 singly are 1-5C alkyl, opt. unsatd. or is a 5- to 7-membered heterocycle, opt. contg. another heteroatom e.g. N, O or S; or Y is where R is 1-5C alkyl, opt. unsatd. or where R5 is phenyl, pyridyl, benzyl or benzoyl, opt. substd. in the aromatic rings by one or two halogen, alkyl, mono- or poly-haloalkyl, alkoxy, mono- or poly-haloalkoxy, alkylthio, mono- or poly-haloalkylthio, alkylenedioxy (in any of which the alkyl groups have 1-5C and may be opt. unsaturated); Z is hydrazino, where R6 is R2, -CO,R2 or R5) are analgesic and psychotropic agents for human and veterinary use, the daily, adult dose being 5-3000 mg orally, 30 to 1500 mg as suppositories and 5 to 600 mg parenterally.
FR7406964A 1974-03-01 1974-03-01 2,4,6-Tri-substd. -1,3,5-triazines - with analgesic and psychotropic activity Granted FR2262512A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7406964A FR2262512A1 (en) 1974-03-01 1974-03-01 2,4,6-Tri-substd. -1,3,5-triazines - with analgesic and psychotropic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7406964A FR2262512A1 (en) 1974-03-01 1974-03-01 2,4,6-Tri-substd. -1,3,5-triazines - with analgesic and psychotropic activity

Publications (2)

Publication Number Publication Date
FR2262512A1 true FR2262512A1 (en) 1975-09-26
FR2262512B1 FR2262512B1 (en) 1977-11-10

Family

ID=9135631

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7406964A Granted FR2262512A1 (en) 1974-03-01 1974-03-01 2,4,6-Tri-substd. -1,3,5-triazines - with analgesic and psychotropic activity

Country Status (1)

Country Link
FR (1) FR2262512A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0065595A2 (en) * 1981-04-08 1982-12-01 Bayer Ag Water-soluble triazine compounds, their preparation and their use
EP0356413A1 (en) * 1988-08-16 1990-02-28 U C B, S.A. 2-Amino-4-morpholino-6-propyl-1,3,5-triazines
EP0356412A1 (en) * 1988-08-16 1990-02-28 U C B, S.A. Use of 2-amino-4-morpholino-6-propyl-1,3,5-triazines in the preparation of a medicament for the treatment of cognitive and mental disorders
WO1999011633A1 (en) * 1997-08-18 1999-03-11 Boehringer Ingelheim Pharma Kg Triazines with an adenosine antagonistic effect
WO2005007648A2 (en) * 2003-07-16 2005-01-27 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
US7662830B2 (en) 2004-08-13 2010-02-16 Neurogen Corporation Substituted biaryl piperazinyl-pyridine analogues

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0065595A2 (en) * 1981-04-08 1982-12-01 Bayer Ag Water-soluble triazine compounds, their preparation and their use
EP0065595A3 (en) * 1981-04-08 1983-04-20 Bayer Ag Water-soluble triazine compounds, their preparation and their use
US4544737A (en) * 1981-04-08 1985-10-01 Bayer Aktiengesellschaft Piperazinyl-triazinylnaphtholsulphonic acid azo dyes
EP0356413A1 (en) * 1988-08-16 1990-02-28 U C B, S.A. 2-Amino-4-morpholino-6-propyl-1,3,5-triazines
EP0356412A1 (en) * 1988-08-16 1990-02-28 U C B, S.A. Use of 2-amino-4-morpholino-6-propyl-1,3,5-triazines in the preparation of a medicament for the treatment of cognitive and mental disorders
US4956367A (en) * 1988-08-16 1990-09-11 U C B S.A. 2-amino-4-morpholino-6-propyl-1,3,5-triazines
WO1999011633A1 (en) * 1997-08-18 1999-03-11 Boehringer Ingelheim Pharma Kg Triazines with an adenosine antagonistic effect
WO2005007648A2 (en) * 2003-07-16 2005-01-27 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
WO2005007648A3 (en) * 2003-07-16 2005-03-24 Neurogen Corp Biaryl piperazinyl-pyridine analogues
JP2007534624A (en) * 2003-07-16 2007-11-29 ニューロジェン・コーポレーション Biaryl piperazinyl-pyridine analogues
US7566712B2 (en) 2003-07-16 2009-07-28 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
US7662830B2 (en) 2004-08-13 2010-02-16 Neurogen Corporation Substituted biaryl piperazinyl-pyridine analogues
US8334382B2 (en) 2004-08-13 2012-12-18 Neurogen Corporation Substituted biaryl piperazinyl-pyridine analogues

Also Published As

Publication number Publication date
FR2262512B1 (en) 1977-11-10

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Legal Events

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