FR2261756A1 - 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity - Google Patents
2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicityInfo
- Publication number
- FR2261756A1 FR2261756A1 FR7406643A FR7406643A FR2261756A1 FR 2261756 A1 FR2261756 A1 FR 2261756A1 FR 7406643 A FR7406643 A FR 7406643A FR 7406643 A FR7406643 A FR 7406643A FR 2261756 A1 FR2261756 A1 FR 2261756A1
- Authority
- FR
- France
- Prior art keywords
- thiazole
- low toxicity
- alkyl
- piperazino
- hypotensive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002220 antihypertensive agent Substances 0.000 title abstract 4
- 208000001953 Hypotension Diseases 0.000 title abstract 2
- 229940030600 antihypertensive agent Drugs 0.000 title abstract 2
- 208000021822 hypotensive Diseases 0.000 title abstract 2
- 230000001077 hypotensive effect Effects 0.000 title abstract 2
- 231100000053 low toxicity Toxicity 0.000 title abstract 2
- 125000005431 alkyl carboxamide group Chemical group 0.000 title 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- -1 propyl- Chemical group 0.000 abstract 2
- ZFIWKJHKLOTFNV-UHFFFAOYSA-N 4-butyl-1,3-thiazole-2-carboxylic acid Chemical class CCCCC1=CSC(C(O)=O)=N1 ZFIWKJHKLOTFNV-UHFFFAOYSA-N 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7406643A FR2261756A1 (en) | 1974-02-27 | 1974-02-27 | 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7406643A FR2261756A1 (en) | 1974-02-27 | 1974-02-27 | 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2261756A1 true FR2261756A1 (en) | 1975-09-19 |
| FR2261756B1 FR2261756B1 (enExample) | 1977-11-04 |
Family
ID=9135516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7406643A Granted FR2261756A1 (en) | 1974-02-27 | 1974-02-27 | 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2261756A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034391A (en) * | 1988-12-06 | 1991-07-23 | Cl Pharma Aktiengesellschaft | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure |
| EP0506194A1 (en) * | 1991-03-25 | 1992-09-30 | Akzo Nobel N.V. | 4-aryl-thiazole or imidazole derivatives |
| WO2003028728A1 (en) * | 2001-09-28 | 2003-04-10 | Richter Gedeon Vegyészeti Gyár Rt. | 4-(4-substituted piperazinyl-1yl)-butylcarboxamides as d3 dopamine subtype selective ligands |
| WO2005028456A1 (en) * | 2003-09-19 | 2005-03-31 | Solvay Pharmaceuticals B.V. | Thiazole derivatives as cannabinoid receptor modulators |
-
1974
- 1974-02-27 FR FR7406643A patent/FR2261756A1/fr active Granted
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034391A (en) * | 1988-12-06 | 1991-07-23 | Cl Pharma Aktiengesellschaft | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure |
| EP0506194A1 (en) * | 1991-03-25 | 1992-09-30 | Akzo Nobel N.V. | 4-aryl-thiazole or imidazole derivatives |
| US5254575A (en) * | 1991-03-25 | 1993-10-19 | Akzo N.V. | 4-aryl-thiazole derivatives |
| US5462959A (en) * | 1991-03-25 | 1995-10-31 | Akzo N.V. | 4-aryl-imidazole derivatives |
| WO2003028728A1 (en) * | 2001-09-28 | 2003-04-10 | Richter Gedeon Vegyészeti Gyár Rt. | 4-(4-substituted piperazinyl-1yl)-butylcarboxamides as d3 dopamine subtype selective ligands |
| WO2005028456A1 (en) * | 2003-09-19 | 2005-03-31 | Solvay Pharmaceuticals B.V. | Thiazole derivatives as cannabinoid receptor modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2261756B1 (enExample) | 1977-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |