FR2244466A1 - Salts of pyridoxine with aryloxy alkanoic acids - useful as antihyperlipemic agents for oral administration - Google Patents

Salts of pyridoxine with aryloxy alkanoic acids - useful as antihyperlipemic agents for oral administration

Info

Publication number
FR2244466A1
FR2244466A1 FR7324314A FR7324314A FR2244466A1 FR 2244466 A1 FR2244466 A1 FR 2244466A1 FR 7324314 A FR7324314 A FR 7324314A FR 7324314 A FR7324314 A FR 7324314A FR 2244466 A1 FR2244466 A1 FR 2244466A1
Authority
FR
France
Prior art keywords
salts
pyridoxine
useful
oral administration
alkanoic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7324314A
Other languages
French (fr)
Other versions
FR2244466B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DUFOUR CLAUDE FR
Original Assignee
DUFOUR CLAUDE FR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DUFOUR CLAUDE FR filed Critical DUFOUR CLAUDE FR
Priority to FR7324314A priority Critical patent/FR2244466A1/en
Publication of FR2244466A1 publication Critical patent/FR2244466A1/en
Application granted granted Critical
Publication of FR2244466B1 publication Critical patent/FR2244466B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pyridoxine-aryloxy alkanoic acid salts are prepd. by mixing cpds. of formula (I) or (II), or pref. by mixing cpds (III) and (II), (where R1 and R2 are H or 1-4C hydrocarbon, and Ar and Ar' are phenyl opt. substd. by >=1 Cl). The salts are used as anti-hyperlipemic agents. The cpds. are mixed in equimolar proportions in a suitable solvent such as acetone or methyl ethyl ketone. The salts may be given orally as tablets at 1000-2000 mg/day for an adult; lowering of blood cholesterol level being noticed after the 4th or 5th day.
FR7324314A 1973-06-29 1973-06-29 Salts of pyridoxine with aryloxy alkanoic acids - useful as antihyperlipemic agents for oral administration Granted FR2244466A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7324314A FR2244466A1 (en) 1973-06-29 1973-06-29 Salts of pyridoxine with aryloxy alkanoic acids - useful as antihyperlipemic agents for oral administration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7324314A FR2244466A1 (en) 1973-06-29 1973-06-29 Salts of pyridoxine with aryloxy alkanoic acids - useful as antihyperlipemic agents for oral administration

Publications (2)

Publication Number Publication Date
FR2244466A1 true FR2244466A1 (en) 1975-04-18
FR2244466B1 FR2244466B1 (en) 1977-07-08

Family

ID=9121949

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7324314A Granted FR2244466A1 (en) 1973-06-29 1973-06-29 Salts of pyridoxine with aryloxy alkanoic acids - useful as antihyperlipemic agents for oral administration

Country Status (1)

Country Link
FR (1) FR2244466A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019324A1 (en) * 1993-02-23 1994-09-01 Laboratori Baldacci Spa Process for the preparation of pyridoxine 5-oxo-2-pyrrolidone carboxylate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019324A1 (en) * 1993-02-23 1994-09-01 Laboratori Baldacci Spa Process for the preparation of pyridoxine 5-oxo-2-pyrrolidone carboxylate

Also Published As

Publication number Publication date
FR2244466B1 (en) 1977-07-08

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Legal Events

Date Code Title Description
ST Notification of lapse