FR2233067A1 - N-(thio)acyl carbamoyl-glycylamino-cephalosporin ic acids - as antibiotics esp. active against pseudomonas and gram neg. organisms producing cephalosporinase - Google Patents

N-(thio)acyl carbamoyl-glycylamino-cephalosporin ic acids - as antibiotics esp. active against pseudomonas and gram neg. organisms producing cephalosporinase

Info

Publication number
FR2233067A1
FR2233067A1 FR7420301A FR7420301A FR2233067A1 FR 2233067 A1 FR2233067 A1 FR 2233067A1 FR 7420301 A FR7420301 A FR 7420301A FR 7420301 A FR7420301 A FR 7420301A FR 2233067 A1 FR2233067 A1 FR 2233067A1
Authority
FR
France
Prior art keywords
cephalosporinase
glycylamino
cephalosporin
esp
thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7420301A
Other languages
French (fr)
Other versions
FR2233067B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB27970/73A external-priority patent/GB1479711A/en
Priority claimed from GB4869873A external-priority patent/GB1387950A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of FR2233067A1 publication Critical patent/FR2233067A1/en
Application granted granted Critical
Publication of FR2233067B1 publication Critical patent/FR2233067B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cpds. (I) (where Y is O or S; R1 is an organic radical contg. up to 20C; R2 is 1-3C alkyl or PhCH2 or R2+R3 together with N and C atoms forms a 5-, 6- or 7-membered ring; R3 is Ph opt. substd. by halogen, OH, NO2, 1-3C alkoxy, or amino, thienyl, 3-7C cycloalkyl or 1-4C alkyl and R4 is acetoxy or a nucleophilic radical linked via a C, N or S atom) are prepd. by acylating a 7-amino- or 7-glyclylamino-cephalosporinic acid or a delta 3 silyl-, ester or S-oxide deriv. there of or replacing a 3-acetoxy group by R4 and then removing blocking groups or S-oxides or isomerising the delta 3 isomers).
FR7420301A 1973-06-12 1974-06-12 N-(thio)acyl carbamoyl-glycylamino-cephalosporin ic acids - as antibiotics esp. active against pseudomonas and gram neg. organisms producing cephalosporinase Granted FR2233067A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB27970/73A GB1479711A (en) 1973-06-12 1973-06-12 Acylureido cephalosporins
GB4869873A GB1387950A (en) 1972-10-20 1973-10-18 Multi-way valve

Publications (2)

Publication Number Publication Date
FR2233067A1 true FR2233067A1 (en) 1975-01-10
FR2233067B1 FR2233067B1 (en) 1978-03-24

Family

ID=26259099

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7420301A Granted FR2233067A1 (en) 1973-06-12 1974-06-12 N-(thio)acyl carbamoyl-glycylamino-cephalosporin ic acids - as antibiotics esp. active against pseudomonas and gram neg. organisms producing cephalosporinase

Country Status (1)

Country Link
FR (1) FR2233067A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2317302A1 (en) * 1975-06-24 1977-02-04 Bayer Ag PROCESS FOR PREPARING ANTIBIOTICS OF THE B-LACTAME TYPE
FR2355848A1 (en) * 1976-06-21 1978-01-20 Lilly Co Eli 7- (A- (2,3-DIHYDRO-2-OXOBENZIMIDAZOL-1-YL-CARBONYLAMINO) ARYLACETAMIDO) CEPHALOSPORINS
FR2358410A1 (en) * 1976-07-14 1978-02-10 Beecham Group Ltd Alpha-benzoyl-ureido-acetamido cephalosporin - useful as broad spectrum antibacterial for human or veterinary medicine
FR2375241A1 (en) * 1976-12-24 1978-07-21 Bayer Ag NEW B-LACTAM TYPE ANTIBIOTICS, THEIR PREPARATION PROCESS AND MEDICINAL PRODUCTS CONTAINING THEM

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687949A (en) * 1969-01-21 1972-08-29 Bristol Myers Co Synthetic cephalosporins
FR2182905A1 (en) * 1972-03-29 1973-12-14 Ciba Geigy Ag

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687949A (en) * 1969-01-21 1972-08-29 Bristol Myers Co Synthetic cephalosporins
FR2182905A1 (en) * 1972-03-29 1973-12-14 Ciba Geigy Ag

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2317302A1 (en) * 1975-06-24 1977-02-04 Bayer Ag PROCESS FOR PREPARING ANTIBIOTICS OF THE B-LACTAME TYPE
FR2355848A1 (en) * 1976-06-21 1978-01-20 Lilly Co Eli 7- (A- (2,3-DIHYDRO-2-OXOBENZIMIDAZOL-1-YL-CARBONYLAMINO) ARYLACETAMIDO) CEPHALOSPORINS
FR2358410A1 (en) * 1976-07-14 1978-02-10 Beecham Group Ltd Alpha-benzoyl-ureido-acetamido cephalosporin - useful as broad spectrum antibacterial for human or veterinary medicine
FR2375241A1 (en) * 1976-12-24 1978-07-21 Bayer Ag NEW B-LACTAM TYPE ANTIBIOTICS, THEIR PREPARATION PROCESS AND MEDICINAL PRODUCTS CONTAINING THEM

Also Published As

Publication number Publication date
FR2233067B1 (en) 1978-03-24

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