FR2229692A1 - 2-Aminomethyl-pyrrolidines obtd. from 3-hydroxy piperidines - by halogenation, reaction with potassium phthalimide and liberation with a strong base - Google Patents

2-Aminomethyl-pyrrolidines obtd. from 3-hydroxy piperidines - by halogenation, reaction with potassium phthalimide and liberation with a strong base

Info

Publication number
FR2229692A1
FR2229692A1 FR7318037A FR7318037A FR2229692A1 FR 2229692 A1 FR2229692 A1 FR 2229692A1 FR 7318037 A FR7318037 A FR 7318037A FR 7318037 A FR7318037 A FR 7318037A FR 2229692 A1 FR2229692 A1 FR 2229692A1
Authority
FR
France
Prior art keywords
cpd
strong base
pyrrolidines
aminomethyl
halogenation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7318037A
Other languages
French (fr)
Other versions
FR2229692B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STEP STE CIVILE MONEGASQUE
Original Assignee
STEP STE CIVILE MONEGASQUE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by STEP STE CIVILE MONEGASQUE filed Critical STEP STE CIVILE MONEGASQUE
Priority to FR7318037A priority Critical patent/FR2229692A1/en
Publication of FR2229692A1 publication Critical patent/FR2229692A1/en
Application granted granted Critical
Publication of FR2229692B1 publication Critical patent/FR2229692B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Novel process for 2-aminomethyl-pyrrolidines of formula (I): (where R is H, alkyl or alkyl gp.), are prepd. by halogenating a 3-hydroxypiperidine cpd. of formula (II): to give a 3-halo-piperidine cpd. and reacting it with K phthalimide to give a cpd. of formula (III): and treating cpd. (III) with a strong base to liberate cpd. (I). The halogen X is pref. Cl, Br or I and the halogenation agent is esp. thionyl chloride or PBr3. The strong base is pref. NaOH. Cpd. (I) is useful as an inter. in org. syntheses.
FR7318037A 1973-05-18 1973-05-18 2-Aminomethyl-pyrrolidines obtd. from 3-hydroxy piperidines - by halogenation, reaction with potassium phthalimide and liberation with a strong base Granted FR2229692A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7318037A FR2229692A1 (en) 1973-05-18 1973-05-18 2-Aminomethyl-pyrrolidines obtd. from 3-hydroxy piperidines - by halogenation, reaction with potassium phthalimide and liberation with a strong base

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7318037A FR2229692A1 (en) 1973-05-18 1973-05-18 2-Aminomethyl-pyrrolidines obtd. from 3-hydroxy piperidines - by halogenation, reaction with potassium phthalimide and liberation with a strong base

Publications (2)

Publication Number Publication Date
FR2229692A1 true FR2229692A1 (en) 1974-12-13
FR2229692B1 FR2229692B1 (en) 1978-09-08

Family

ID=9119528

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7318037A Granted FR2229692A1 (en) 1973-05-18 1973-05-18 2-Aminomethyl-pyrrolidines obtd. from 3-hydroxy piperidines - by halogenation, reaction with potassium phthalimide and liberation with a strong base

Country Status (1)

Country Link
FR (1) FR2229692A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1580165A (en) * 1968-02-16 1969-09-05
FR1602744A (en) * 1968-02-16 1971-01-18

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1580165A (en) * 1968-02-16 1969-09-05
FR1602744A (en) * 1968-02-16 1971-01-18

Also Published As

Publication number Publication date
FR2229692B1 (en) 1978-09-08

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Legal Events

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