FR2208650A2 - 4'-aminomethyl-spiro(dibenzo(a,d)cycloheptadi(or tri) - ene-5,2' -(1,3)dioxolan)- antidepressants,analgesics,antiinflammatory - Google Patents

4'-aminomethyl-spiro(dibenzo(a,d)cycloheptadi(or tri) - ene-5,2' -(1,3)dioxolan)- antidepressants,analgesics,antiinflammatory

Info

Publication number
FR2208650A2
FR2208650A2 FR7242867A FR7242867A FR2208650A2 FR 2208650 A2 FR2208650 A2 FR 2208650A2 FR 7242867 A FR7242867 A FR 7242867A FR 7242867 A FR7242867 A FR 7242867A FR 2208650 A2 FR2208650 A2 FR 2208650A2
Authority
FR
France
Prior art keywords
cycloheptadi
dioxolan
dibenzo
antidepressants
antiinflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7242867A
Other languages
French (fr)
Other versions
FR2208650B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE793611D priority Critical patent/BE793611A/en
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7242867A priority patent/FR2208650A2/en
Priority to ZA730009A priority patent/ZA739B/en
Priority to GB31173A priority patent/GB1346163A/en
Priority to CH2173A priority patent/CH549012A/en
Priority to SE7300133A priority patent/SE395003B/en
Priority to DE19732300519 priority patent/DE2300519C3/en
Priority to LU66795A priority patent/LU66795A1/xx
Priority to AU50889/73A priority patent/AU466588B2/en
Priority to ES410470A priority patent/ES410470A2/en
Priority to NL7300432A priority patent/NL163513C/en
Priority to JP713173A priority patent/JPS4986369A/ja
Priority to IT6723573A priority patent/IT1055524B/en
Priority to CA164,402*7A priority patent/CA945158A/en
Priority to SU1886669A priority patent/SU504488A3/en
Publication of FR2208650A2 publication Critical patent/FR2208650A2/en
Priority to JP14689574A priority patent/JPS50140446A/ja
Application granted granted Critical
Publication of FR2208650B2 publication Critical patent/FR2208650B2/fr
Priority to JP8156480A priority patent/JPS5618977A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Title cpds. are of the formula: (where Z = -CH2-CH2- or -CH=CH-; R = (1-4C) alkyl). They are also useful as duretics, vasodilators, anti-arrythmics, spasmolytics, antieholinergics, antihistaminics, antiulcer agents, serotonin antagonists and positive intropics.
FR7242867A 1972-12-01 1972-12-01 4'-aminomethyl-spiro(dibenzo(a,d)cycloheptadi(or tri) - ene-5,2' -(1,3)dioxolan)- antidepressants,analgesics,antiinflammatory Granted FR2208650A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
BE793611D BE793611A (en) 1972-12-01 NEW DERIVATIVES OF AMINOMETHYL-4'SPIRO (DIBENZO (A-D) CYCLOHEPTADI- (OR TRI-) ENE-5: 2'-DIOXOLANE (1 ', 3')), THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR7242867A FR2208650A2 (en) 1972-12-01 1972-12-01 4'-aminomethyl-spiro(dibenzo(a,d)cycloheptadi(or tri) - ene-5,2' -(1,3)dioxolan)- antidepressants,analgesics,antiinflammatory
ZA730009A ZA739B (en) 1972-12-01 1973-01-02 New derivatives of 4'-aminomethyl spiro(dibenzo(a-d)cycloheptadi-(or tri-)ene-5:2'-dioxolane (1',3') their method of preparation and their therapeutic application
GB31173A GB1346163A (en) 1972-12-01 1973-01-03 Alkyl derivatives of 3-aminomethyl spiro -dibenzo-a-d- cycloheptadi-or tri-ene 5-2- dioxolane 1,3- their method of preparation and their therapeutic application
CH2173A CH549012A (en) 1972-12-01 1973-01-03 PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF AMINOMETHYL-4 'SPIRO (DIBENZO (A-D) CYCLOHEPTADI- (OR TRI-) ENE5: 2' -DIOXOLANE (1 ', 3')).
SE7300133A SE395003B (en) 1972-12-01 1973-01-04 METHOD OF MAKING DERIVATIVES OF 4 '- AMINOMETHYL - SPIRO (DIBENSO (A, D) - CYCLOHEPTA -DI- (OR-TRI) A 5: 2'-DIOXOLANE (1', 3)) WITH PHARMACOLOGICAL PROPERTIES
LU66795A LU66795A1 (en) 1972-12-01 1973-01-05
DE19732300519 DE2300519C3 (en) 1972-12-01 1973-01-05 4'-aminomethyl-spiro- [dibenzo (a, d) cycloheptadi- (or-tri) en-5,2'-dioxolane d'3 ')] derivatives, processes for their preparation and pharmaceuticals containing these compounds
AU50889/73A AU466588B2 (en) 1972-12-01 1973-01-09 Alkyl derivatives of 4'-aminomethyl spiro [dibenzo (a-d) cycloheptadi-(or tri-) ene-5: 2' - dioxolane (1'-3'], their method of preparation and their therapeutic application
ES410470A ES410470A2 (en) 1972-12-01 1973-01-09 Alkyl derivatives of 3-aminomethyl spiro -dibenzo-a-d- cycloheptadi-or tri-ene 5-2- dioxolane 1,3- their method of preparation and their therapeutic application
NL7300432A NL163513C (en) 1972-12-01 1973-01-11 PROCESS FOR PREPARING A MEDICINAL PRODUCT BASED ON 4'-AMINOMETHYL-SPIROĊ¸5,2'-DIBENZO (A, D) CYCLOHEPTADI (OR TRI) -EN-1'3'-DIOXOLANĊ¸ COMPOUNDS, THE FORMS OF THE PREVENTED PRODUCT PREPARATION OF THE SUITABLE 4'-AMINOMETHYL-SPIRO'5,2'-DIBENZO (A, D) CYCLOHEPTADI (OR TRI) ONE-1'3'-DIOXOLAN COMPOUNDS.
JP713173A JPS4986369A (en) 1972-12-01 1973-01-17
IT6723573A IT1055524B (en) 1972-12-01 1973-02-05 ORIGINAL DERIVATIVES OF AMINOMETHY 4 SPIRO DIBENZO A CICLOEPTADIO TRI ENE 5.2 DIOXIDE 1,3, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION IN THERAPY
CA164,402*7A CA945158A (en) 1972-12-01 1973-02-21 Derives de l'aminomethyl-4' spiro (dibenzo (a-d) cycloheptadi- (ou tri-) ene-5 : 2'-dioxolane (1',3')), leur procede de preparation et leur application en therapeutique
SU1886669A SU504488A3 (en) 1972-12-01 1973-02-27 The method of obtaining derivatives of spiro (dibenzo (a-d) cycloheptadi (or three) -en-5: 2 "- (4" -aminomethyldioxolane-1 ", 3"))
JP14689574A JPS50140446A (en) 1972-12-01 1974-12-23
JP8156480A JPS5618977A (en) 1972-12-01 1980-06-18 Manufacture of 4**aminomethylspiro*dibenzo*aa d*cycloheptadi*or tri*enee5 2**dioxolanee *1**3** derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7242867A FR2208650A2 (en) 1972-12-01 1972-12-01 4'-aminomethyl-spiro(dibenzo(a,d)cycloheptadi(or tri) - ene-5,2' -(1,3)dioxolan)- antidepressants,analgesics,antiinflammatory

Publications (2)

Publication Number Publication Date
FR2208650A2 true FR2208650A2 (en) 1974-06-28
FR2208650B2 FR2208650B2 (en) 1975-11-28

Family

ID=9108086

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7242867A Granted FR2208650A2 (en) 1972-12-01 1972-12-01 4'-aminomethyl-spiro(dibenzo(a,d)cycloheptadi(or tri) - ene-5,2' -(1,3)dioxolan)- antidepressants,analgesics,antiinflammatory

Country Status (4)

Country Link
JP (1) JPS5618977A (en)
AU (1) AU466588B2 (en)
FR (1) FR2208650A2 (en)
ZA (1) ZA739B (en)

Also Published As

Publication number Publication date
FR2208650B2 (en) 1975-11-28
AU5088973A (en) 1974-07-11
ZA739B (en) 1973-09-26
AU466588B2 (en) 1975-10-30
JPS5618977A (en) 1981-02-23

Similar Documents

Publication Publication Date Title
AU507427B2 (en) Subsea drilling'production station
IT8821100A0 (en) IMPROVED MACHINE FOR THE PRODUCTION OF SLUSH.
JPS5382792A (en) Novel antibiotics mazethramycins and process their preparation
AU2950177A (en) Track maintenance machine
DE3878340D1 (en) CRYSTALLINE L-CARNOSINE-ZINC COMPLEX AND THEIR PRODUCTION.
KR900700420A (en) Method for producing 2,3-difluorobenzene
BE857493A (en) PROCESS FOR OBTAINING BACTERIAL STRAINS
IL51213A0 (en) The production of 4,4'-isopropylidene-bis-(2,6-dibromophenol)
ZA793739B (en) New piperidine compounds,the process for their preparation and their use as stabilisers for synthetic polymers
DE69107351D1 (en) Mass for the production of coating films.
AU506408B2 (en) 1, 4-Benzodioxane derivatives
ES456243A1 (en) 3-Substituted-4-aminoalkoxy-5,6-condensed ring-2-pyranones
AU2232177A (en) Track tamping machine
IT8048978A0 (en) PROCEDURE FOR THE PRODUCTION OF THE ANTIBIOTIC CEFAMICIN C
ZA774887B (en) New process for the manufacture of 5-amino-1,2,3,-thiadiazole
FR2208652A2 (en) 4'-aminomethyl-spiro(dibenzo(a,d)cycloheptadi(or tri) - ene-5,2' -(1,3)dioxolan)- antidepressants,analgesics,antiinflammatory
FR2208650A2 (en) 4'-aminomethyl-spiro(dibenzo(a,d)cycloheptadi(or tri) - ene-5,2' -(1,3)dioxolan)- antidepressants,analgesics,antiinflammatory
IE45901L (en) Pyridine derivatives
IT8919879A0 (en) BRICK BY INSUFFLATION.
IE790950L (en) Pyridopyrimidones plastics web with a three-dimension microstructure
IE43717L (en) Alkylsulphonylamino phenyl cephalosporins.
PL196355A1 (en) METHOD OF MICROBIOLOGICAL PRODUCTION OF THE MIXTURE OF ANDROSTADIENE-1,4-DIONE-3.17 AND ANDROSTENO-4-DIONE-3.17
EP0038003A3 (en) Antidepressant pyrrolylpiperidines
IE38320L (en) Nor-morphines and nor-codeines
JPS51151968A (en) Suspended type vehicle