FR2189049A1 - 6-Spiro-cyclopropyl-steroids - with aldosterone antagonist activity - Google Patents
6-Spiro-cyclopropyl-steroids - with aldosterone antagonist activityInfo
- Publication number
- FR2189049A1 FR2189049A1 FR7322139A FR7322139A FR2189049A1 FR 2189049 A1 FR2189049 A1 FR 2189049A1 FR 7322139 A FR7322139 A FR 7322139A FR 7322139 A FR7322139 A FR 7322139A FR 2189049 A1 FR2189049 A1 FR 2189049A1
- Authority
- FR
- France
- Prior art keywords
- steroids
- spiro
- cyclopropyl
- antagonist activity
- aldosterone antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
Steriods of formula (I): (where the dotted line indicates the opt. presence of DELTA 1-unsatn.; R is CH3 or, when there is a single bond in the 1,2-posn., H or CH3; R1 is H or 1-7C alkyl; and M is H, alkali metal, alkaline earth metal/2, or an ammonium residue), which have diuretic activity which is higher than that of the corresponding lactones and also have various hormonal (e.g., anabolic, androgenic, progestational, anti-oestrogenic) props., are prepd. by treating a lactone of formula (II): to give (I: M = alkali metal or alkaline earth metal/2) and opt. converting this into the free acid or into a different salt.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26413772A | 1972-06-19 | 1972-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2189049A1 true FR2189049A1 (en) | 1974-01-25 |
Family
ID=23004752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7322139A Withdrawn FR2189049A1 (en) | 1972-06-19 | 1973-06-18 | 6-Spiro-cyclopropyl-steroids - with aldosterone antagonist activity |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPS4961149A (en) |
DE (1) | DE2330993A1 (en) |
FR (1) | FR2189049A1 (en) |
-
1973
- 1973-06-18 FR FR7322139A patent/FR2189049A1/en not_active Withdrawn
- 1973-06-18 JP JP6861073A patent/JPS4961149A/ja active Pending
- 1973-06-18 DE DE19732330993 patent/DE2330993A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS4961149A (en) | 1974-06-13 |
DE2330993A1 (en) | 1974-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |