FR2187312A1 - Rapidly-soluble paracetamol - prepd by recrystallization from aqueous dioxan - Google Patents
Rapidly-soluble paracetamol - prepd by recrystallization from aqueous dioxanInfo
- Publication number
- FR2187312A1 FR2187312A1 FR7220126A FR7220126A FR2187312A1 FR 2187312 A1 FR2187312 A1 FR 2187312A1 FR 7220126 A FR7220126 A FR 7220126A FR 7220126 A FR7220126 A FR 7220126A FR 2187312 A1 FR2187312 A1 FR 2187312A1
- Authority
- FR
- France
- Prior art keywords
- prepd
- rapidly
- recrystallization
- paracetamol
- aqueous dioxan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title abstract 3
- 229960005489 paracetamol Drugs 0.000 title abstract 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 title abstract 2
- 238000001953 recrystallisation Methods 0.000 title 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 229940046978 chlorpheniramine maleate Drugs 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Detergent Compositions (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7220126A FR2187312A1 (en) | 1972-06-05 | 1972-06-05 | Rapidly-soluble paracetamol - prepd by recrystallization from aqueous dioxan |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7220126A FR2187312A1 (en) | 1972-06-05 | 1972-06-05 | Rapidly-soluble paracetamol - prepd by recrystallization from aqueous dioxan |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2187312A1 true FR2187312A1 (en) | 1974-01-18 |
FR2187312B1 FR2187312B1 (enrdf_load_stackoverflow) | 1976-03-05 |
Family
ID=9099681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7220126A Granted FR2187312A1 (en) | 1972-06-05 | 1972-06-05 | Rapidly-soluble paracetamol - prepd by recrystallization from aqueous dioxan |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2187312A1 (enrdf_load_stackoverflow) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0011489A1 (en) * | 1978-11-16 | 1980-05-28 | Beecham Group Plc | An analgesic effervescent powder and process for its preparation |
FR2586561A1 (fr) * | 1985-09-05 | 1987-03-06 | Rhone Poulenc Sante | Procede de preparation d'agglomerats spheriques de paracetamol et produits obtenus |
FR2672212A1 (fr) * | 1991-02-04 | 1992-08-07 | Lille Ii Universite | Cristaux de paracetamol pour compression directe, procede de preparation de ces cristaux et comprime obtenu avec ces cristaux. |
WO2023219592A3 (en) * | 2022-05-09 | 2024-03-14 | Atabay Kimya Sanayi Ve Tic. A.S. | A tablet composition comprising paracetamol, chlorpheniramine and ascorbic acid |
-
1972
- 1972-06-05 FR FR7220126A patent/FR2187312A1/fr active Granted
Non-Patent Citations (1)
Title |
---|
NEANT * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0011489A1 (en) * | 1978-11-16 | 1980-05-28 | Beecham Group Plc | An analgesic effervescent powder and process for its preparation |
FR2586561A1 (fr) * | 1985-09-05 | 1987-03-06 | Rhone Poulenc Sante | Procede de preparation d'agglomerats spheriques de paracetamol et produits obtenus |
EP0219377A1 (fr) * | 1985-09-05 | 1987-04-22 | Rhone-Poulenc Sante | Procédé de préparation d'agglomerats sphériques de paracétamol et produits obtenus |
FR2672212A1 (fr) * | 1991-02-04 | 1992-08-07 | Lille Ii Universite | Cristaux de paracetamol pour compression directe, procede de preparation de ces cristaux et comprime obtenu avec ces cristaux. |
WO2023219592A3 (en) * | 2022-05-09 | 2024-03-14 | Atabay Kimya Sanayi Ve Tic. A.S. | A tablet composition comprising paracetamol, chlorpheniramine and ascorbic acid |
Also Published As
Publication number | Publication date |
---|---|
FR2187312B1 (enrdf_load_stackoverflow) | 1976-03-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |