FR2154336A1 - Diphenyl propargyl aminoethyl acetamides - analgesics and neurosedative potentiators - Google Patents

Diphenyl propargyl aminoethyl acetamides - analgesics and neurosedative potentiators

Info

Publication number
FR2154336A1
FR2154336A1 FR7135175A FR7135175A FR2154336A1 FR 2154336 A1 FR2154336 A1 FR 2154336A1 FR 7135175 A FR7135175 A FR 7135175A FR 7135175 A FR7135175 A FR 7135175A FR 2154336 A1 FR2154336 A1 FR 2154336A1
Authority
FR
France
Prior art keywords
neurosedative
potentiators
acetamides
analgesics
aminoethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7135175A
Other languages
French (fr)
Other versions
FR2154336B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7135175A priority Critical patent/FR2154336A1/en
Publication of FR2154336A1 publication Critical patent/FR2154336A1/en
Application granted granted Critical
Publication of FR2154336B1 publication Critical patent/FR2154336B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

Title cpds. are of formula (I): (where R1 = H or alkyl (1-4C); R2 = H; R3 = alkyl (1-4C); R4 = alkyl (1-4C), aryl or aralkyl, or R1 and R3 together with the atoms linking them form a 6-membered heterocycle or R3 and R4 together with the N atom form a 5- or 6-membered heterocycle). These cpds. are prepd. from a diphenylacetic ester by treatment with a propargyl halide followed by saponification, prepn. of an acid halide, and treatment with the appropriate diamine.
FR7135175A 1971-09-30 1971-09-30 Diphenyl propargyl aminoethyl acetamides - analgesics and neurosedative potentiators Granted FR2154336A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7135175A FR2154336A1 (en) 1971-09-30 1971-09-30 Diphenyl propargyl aminoethyl acetamides - analgesics and neurosedative potentiators

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7135175A FR2154336A1 (en) 1971-09-30 1971-09-30 Diphenyl propargyl aminoethyl acetamides - analgesics and neurosedative potentiators

Publications (2)

Publication Number Publication Date
FR2154336A1 true FR2154336A1 (en) 1973-05-11
FR2154336B1 FR2154336B1 (en) 1974-11-15

Family

ID=9083710

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7135175A Granted FR2154336A1 (en) 1971-09-30 1971-09-30 Diphenyl propargyl aminoethyl acetamides - analgesics and neurosedative potentiators

Country Status (1)

Country Link
FR (1) FR2154336A1 (en)

Also Published As

Publication number Publication date
FR2154336B1 (en) 1974-11-15

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Legal Events

Date Code Title Description
ST Notification of lapse