FR2150722A1 - Substd pyrimidines - hypotensives and analgesics - Google Patents

Substd pyrimidines - hypotensives and analgesics

Info

Publication number
FR2150722A1
FR2150722A1 FR7227858A FR7227858A FR2150722A1 FR 2150722 A1 FR2150722 A1 FR 2150722A1 FR 7227858 A FR7227858 A FR 7227858A FR 7227858 A FR7227858 A FR 7227858A FR 2150722 A1 FR2150722 A1 FR 2150722A1
Authority
FR
France
Prior art keywords
alkyl
substd
hypotensives
pyrimidines
analgesics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7227858A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of FR2150722A1 publication Critical patent/FR2150722A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds have formula (I): where R1, R2 and R3 = H,OH,SH, (1-4C) alkyl, (1-4C)O-alkyl, (1-4C) S-alkyl, (3-6C) cycloalkyl or cycloalkenyl, aryl, hal, NH2, NH(1-4C) alkyl, N/(1-4C) alkyl/2, CN, CO2H, (1-5C) CO2 alkyl, opt. substd. CONH2, or CHO, >=1 being other than H, O alkyl or a hydrocarbon residue; A = (2-6C) alkylene, X = O or S, and Z = H, hal, CF3, (1-4C) alkyl, (1-4C) O-alkyl, or (1-4C) S alkyl. (I) are prepd. (a) by condensing a 4-halo-pyrimidine with apiperazinyl alkanol or alkane thil, (b) similarly from a substd. piperazine and 4-O- or S-(omega-haloalkane), or (c) by in situ synthesis of the piperazinyl residue e.g. from an amine and an N (bis-bromo ethane) deriv.
FR7227858A 1971-08-04 1972-08-02 Substd pyrimidines - hypotensives and analgesics Withdrawn FR2150722A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712139082 DE2139082A1 (en) 1971-08-04 1971-08-04 SUBSTITUTED PYRIMIDINS, METHOD OF MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM

Publications (1)

Publication Number Publication Date
FR2150722A1 true FR2150722A1 (en) 1973-04-13

Family

ID=5815787

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7227858A Withdrawn FR2150722A1 (en) 1971-08-04 1972-08-02 Substd pyrimidines - hypotensives and analgesics

Country Status (6)

Country Link
JP (1) JPS4826777A (en)
BE (1) BE787125A (en)
DE (1) DE2139082A1 (en)
FR (1) FR2150722A1 (en)
LU (1) LU65836A1 (en)
NL (1) NL7210636A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425143A1 (en) * 1994-07-15 1996-01-18 Basf Ag Substituted pyrimidine compounds and their use

Also Published As

Publication number Publication date
BE787125A (en) 1973-02-05
DE2139082A1 (en) 1973-02-15
LU65836A1 (en) 1973-08-17
JPS4826777A (en) 1973-04-09
NL7210636A (en) 1973-02-06

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Legal Events

Date Code Title Description
RE Withdrawal of published application