FR2124104A1 - Tri-tetracylline-methyl derivs of polypeptides - - broad-spectrum antibiotics - Google Patents

Info

Publication number

FR2124104A1

FR2124104A1 FR7103957A FR7103957A FR2124104A1 FR 2124104 A1 FR2124104 A1 FR 2124104A1 FR 7103957 A FR7103957 A FR 7103957A FR 7103957 A FR7103957 A FR 7103957A FR 2124104 A1 FR2124104 A1 FR 2124104A1

Authority

FR

France

Prior art keywords

tetracylline

polypeptides

tri

broad

spectrum antibiotics

Prior art date

1971-02-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• Global Dossier
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• 229920001184 polypeptide Polymers 0.000 title abstract 2
• 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
• 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
• 239000003242 anti bacterial agent Substances 0.000 title 1
• 229940088710 antibiotic agent Drugs 0.000 title 1
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
• 108010078777 Colistin Proteins 0.000 abstract 1
• 238000006683 Mannich reaction Methods 0.000 abstract 1
• AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 abstract 1
• 239000004098 Tetracycline Substances 0.000 abstract 1
• 229960003346 colistin Drugs 0.000 abstract 1
• 238000002347 injection Methods 0.000 abstract 1
• 239000007924 injection Substances 0.000 abstract 1
• SXQFCVDSOLSHOQ-UHFFFAOYSA-N lactamide Chemical compound CC(O)C(N)=O SXQFCVDSOLSHOQ-UHFFFAOYSA-N 0.000 abstract 1
• JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 abstract 1
• 239000008194 pharmaceutical composition Substances 0.000 abstract 1
• -1 poly(hydroxy methyl) Polymers 0.000 abstract 1
• XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 abstract 1
• KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 abstract 1
• 239000003910 polypeptide antibiotic agent Substances 0.000 abstract 1
• 239000003755 preservative agent Substances 0.000 abstract 1
• 230000002335 preservative effect Effects 0.000 abstract 1
• 229960002180 tetracycline Drugs 0.000 abstract 1
• 229930101283 tetracycline Natural products 0.000 abstract 1
• 235000019364 tetracycline Nutrition 0.000 abstract 1
• 229940072172 tetracycline antibiotic Drugs 0.000 abstract 1
• 150000003522 tetracyclines Chemical class 0.000 abstract 1