FR2114254A5 - Alpha-trisubstd acetonitriles prepn - esp 2,2-dimethyl valeronitrile, from disubstd acetonitriles sodamide and alkyl halide - Google Patents

Alpha-trisubstd acetonitriles prepn - esp 2,2-dimethyl valeronitrile, from disubstd acetonitriles sodamide and alkyl halide

Info

Publication number
FR2114254A5
FR2114254A5 FR7041780A FR7041780A FR2114254A5 FR 2114254 A5 FR2114254 A5 FR 2114254A5 FR 7041780 A FR7041780 A FR 7041780A FR 7041780 A FR7041780 A FR 7041780A FR 2114254 A5 FR2114254 A5 FR 2114254A5
Authority
FR
France
Prior art keywords
acetonitriles
trisubstd
prepn
esp
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7041780A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boyer and Cie
Original Assignee
Boyer and Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boyer and Cie filed Critical Boyer and Cie
Priority to FR7041780A priority Critical patent/FR2114254A5/en
Priority to CH1679171A priority patent/CH546744A/en
Priority to DE19712157545 priority patent/DE2157545A1/en
Application granted granted Critical
Publication of FR2114254A5 publication Critical patent/FR2114254A5/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

alpha-Trisubstd. acetonitriles of formula: R1R2R3C-C triple bond N (where R1 and R3 are opt. same and are Me or Et and Re is 2-4C opt. unsatd. alkyl or aryl), pref. 2,2-dimethylvaleronitrile, are useful starting materials for prepn. of amides and carboxylic acids, their salts and esters, which have therapeutic, esp. transquilising activity. They are prepd. by reacting R1R3CH-C triple bond N with NaNH2 and R2Hal, where NaNH2 is prepd. in situ by reacting metallic Na with anhydrous liquid NH3 in excess under completely anhydrous condns. and in presence of traces of Fe (III)-salt as catalyst. Residual liquid NH3 is displaced with completely anhydrous benzene or toluene, NaNH2 is reacted with R1R3CH-C triple bond N and R2Hal under completely anhydrous condns. and boiling and prod. formed is sepd. from reaction mixt.
FR7041780A 1970-11-20 1970-11-20 Alpha-trisubstd acetonitriles prepn - esp 2,2-dimethyl valeronitrile, from disubstd acetonitriles sodamide and alkyl halide Expired FR2114254A5 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR7041780A FR2114254A5 (en) 1970-11-20 1970-11-20 Alpha-trisubstd acetonitriles prepn - esp 2,2-dimethyl valeronitrile, from disubstd acetonitriles sodamide and alkyl halide
CH1679171A CH546744A (en) 1970-11-20 1971-11-18 PROCESS FOR PREPARING AN ACETIC NITRILE (ALPHA) -TRISUBSTITUTE.
DE19712157545 DE2157545A1 (en) 1970-11-20 1971-11-19 Alpha-Trisubstituted Acetonitriles and Process for Their Preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7041780A FR2114254A5 (en) 1970-11-20 1970-11-20 Alpha-trisubstd acetonitriles prepn - esp 2,2-dimethyl valeronitrile, from disubstd acetonitriles sodamide and alkyl halide

Publications (1)

Publication Number Publication Date
FR2114254A5 true FR2114254A5 (en) 1972-06-30

Family

ID=9064491

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7041780A Expired FR2114254A5 (en) 1970-11-20 1970-11-20 Alpha-trisubstd acetonitriles prepn - esp 2,2-dimethyl valeronitrile, from disubstd acetonitriles sodamide and alkyl halide

Country Status (3)

Country Link
CH (1) CH546744A (en)
DE (1) DE2157545A1 (en)
FR (1) FR2114254A5 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4776810B2 (en) * 2001-05-30 2011-09-21 日本曹達株式会社 Method for producing α-position trisubstituted acetic acid

Also Published As

Publication number Publication date
DE2157545A1 (en) 1972-06-29
CH546744A (en) 1974-03-15

Similar Documents

Publication Publication Date Title
NL6912790A (en) 2,2-Di-methyl-omega-aryloxyalkane acids, salts and esters
GB1042631A (en) New fused polycyclic hydrocarbon derivatives and processes for the preparation thereof
FR2114254A5 (en) Alpha-trisubstd acetonitriles prepn - esp 2,2-dimethyl valeronitrile, from disubstd acetonitriles sodamide and alkyl halide
GB1367957A (en) Process for preparing cephalosporins
GB1155018A (en) Acyloxy Thiazolidine Compounds and process for their Manufacture
GB1304925A (en)
GB1424186A (en) Penicillins
GB1323183A (en) Cyclopropane esters and acids thereof
GB1423495A (en) Oligocarboxyalkane-phosphonic acids and process for makiing them
SE321485B (en)
GB1338023A (en) Pyridylamino-methylenemalonates
GB1433818A (en) Process for producing indan derivatives
GB977074A (en) Improvements in and relating to amines
ES345289A1 (en) Process for the preparation of intermediates for the synthesis of steroids
GB1069337A (en) Basically substituted bis-naphthalimides and their production
ES394894A1 (en) Phenylacetohydroxamic acids process for their manufacture and preparations containing them
SU537069A1 (en) The method of obtaining-acyl-arylhydrazide disubstituted glycolic acids
GB1291687A (en) A method for the production of formylnitrile derivatives
GB1206099A (en) New alkoxyalkyl esters of octahydro-1,2,4-methenopentalene-5-carboxylic acid, and process for their production
GB935610A (en) 3ªá-amino-pregnane compounds
DE3160295D1 (en) Process for the preparation of n-acyl amides of alpha-ketocarboxylic acids
GB752692A (en) Improvements in aminoacetic acid derivatives
GB1396810A (en) Process for the preparation of 2,3,4,5,6,7-hexahydrocyclopenta-e -1,3-oxazine-2,4-diones
GB1451594A (en) Process for the preparation of unsaturated cyanocarbonyl com pounds
ES395559A1 (en) Procedure for the obtaining of tetracycline alkylsulphamates. (Machine-translation by Google Translate, not legally binding)

Legal Events

Date Code Title Description
ST Notification of lapse