FR2113947A1 - Oral raubasine compositions - also contg polyethylene glycol to improve resorption - Google Patents

Oral raubasine compositions - also contg polyethylene glycol to improve resorption

Info

Publication number
FR2113947A1
FR2113947A1 FR7140569A FR7140569A FR2113947A1 FR 2113947 A1 FR2113947 A1 FR 2113947A1 FR 7140569 A FR7140569 A FR 7140569A FR 7140569 A FR7140569 A FR 7140569A FR 2113947 A1 FR2113947 A1 FR 2113947A1
Authority
FR
France
Prior art keywords
raubasine
polyethylene glycol
contg
oral
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7140569A
Other languages
French (fr)
Other versions
FR2113947B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of FR2113947A1 publication Critical patent/FR2113947A1/en
Application granted granted Critical
Publication of FR2113947B1 publication Critical patent/FR2113947B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compsns. produced by homogeneously mixing raubasine with polyethylene glycol of mean mol. wt. 4000-25000 and compressing to tablets or granules are useful in the treatment of arterial hypertension and arterial and venous circulatory disorders and give better GI-absorption of raubasine than previously used oral preparations. Further additives may be incorporated into the compsns., particularly wetting agents, whic shorten the disintegration time of the compsn. and further improve resorption, as well as additional active substances, esp. methyldigoxin or digoxin.
FR7140569A 1970-11-13 1971-11-12 Oral raubasine compositions - also contg polyethylene glycol to improve resorption Granted FR2113947A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19702055930 DE2055930A1 (en) 1970-11-13 1970-11-13 Improved oral application form of Raubasin

Publications (2)

Publication Number Publication Date
FR2113947A1 true FR2113947A1 (en) 1972-06-30
FR2113947B1 FR2113947B1 (en) 1975-10-31

Family

ID=5788038

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7140569A Granted FR2113947A1 (en) 1970-11-13 1971-11-12 Oral raubasine compositions - also contg polyethylene glycol to improve resorption

Country Status (5)

Country Link
JP (1) JPS5511645B1 (en)
AT (1) AT309690B (en)
DE (1) DE2055930A1 (en)
FR (1) FR2113947A1 (en)
NL (1) NL7115494A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2204425A1 (en) * 1972-10-31 1974-05-24 Hoechst Ag
EP0381182A2 (en) * 1989-01-31 1990-08-08 Ipa Internationale Pharma Agentur Gmbh An erosion-controlled release system for active agents and a process for its preparation
FR2671727A1 (en) * 1991-01-18 1992-07-24 Nawrocki Thadee Use of raubasine for treating poor iron metabolism

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4311694A (en) 1979-12-31 1982-01-19 American Cyanamid Company Amorphous coprecipitates of 4-(monoalkylamino) benzoic acid and derivatives and certain water-soluble materials

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2204425A1 (en) * 1972-10-31 1974-05-24 Hoechst Ag
EP0381182A2 (en) * 1989-01-31 1990-08-08 Ipa Internationale Pharma Agentur Gmbh An erosion-controlled release system for active agents and a process for its preparation
EP0381182A3 (en) * 1989-01-31 1991-01-09 Ipa Internationale Pharma Agentur Gmbh An erosion-controlled release system for active agents and a process for its preparation
FR2671727A1 (en) * 1991-01-18 1992-07-24 Nawrocki Thadee Use of raubasine for treating poor iron metabolism

Also Published As

Publication number Publication date
AT309690B (en) 1973-08-27
DE2055930A1 (en) 1972-05-18
NL7115494A (en) 1972-05-16
FR2113947B1 (en) 1975-10-31
JPS5511645B1 (en) 1980-03-26

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