FR2100936A1 - Injectable narcotic antagonist - formulation with long duration of action - Google Patents
Injectable narcotic antagonist - formulation with long duration of actionInfo
- Publication number
- FR2100936A1 FR2100936A1 FR7126507A FR7126507A FR2100936A1 FR 2100936 A1 FR2100936 A1 FR 2100936A1 FR 7126507 A FR7126507 A FR 7126507A FR 7126507 A FR7126507 A FR 7126507A FR 2100936 A1 FR2100936 A1 FR 2100936A1
- Authority
- FR
- France
- Prior art keywords
- action
- pamoate
- long duration
- formulation
- hydroxynormorphinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000003887 narcotic antagonist Substances 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 3
- BFXHRYXMFBRRFN-SXYFAJAHSA-N (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid Chemical compound Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O.Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O.OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O BFXHRYXMFBRRFN-SXYFAJAHSA-N 0.000 abstract 1
- 244000105624 Arachis hypogaea Species 0.000 abstract 1
- 235000019483 Peanut oil Nutrition 0.000 abstract 1
- 244000000231 Sesamum indicum Species 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000002285 corn oil Substances 0.000 abstract 1
- 235000005687 corn oil Nutrition 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 239000002385 cottonseed oil Substances 0.000 abstract 1
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000010255 intramuscular injection Methods 0.000 abstract 1
- 239000004081 narcotic agent Substances 0.000 abstract 1
- 239000000312 peanut oil Substances 0.000 abstract 1
- 239000002574 poison Substances 0.000 abstract 1
- 231100000614 poison Toxicity 0.000 abstract 1
- 239000008159 sesame oil Substances 0.000 abstract 1
- 235000011803 sesame oil Nutrition 0.000 abstract 1
- 238000010254 subcutaneous injection Methods 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5697570A | 1970-07-21 | 1970-07-21 | |
| US12033671A | 1971-03-02 | 1971-03-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2100936A1 true FR2100936A1 (en) | 1972-03-24 |
| FR2100936B1 FR2100936B1 (enExample) | 1974-09-06 |
Family
ID=26735916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7126507A Granted FR2100936A1 (en) | 1970-07-21 | 1971-07-20 | Injectable narcotic antagonist - formulation with long duration of action |
Country Status (3)
| Country | Link |
|---|---|
| CA (1) | CA964192A (enExample) |
| DE (1) | DE2135856A1 (enExample) |
| FR (1) | FR2100936A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0472501A3 (en) * | 1990-08-23 | 1993-02-24 | Ciba-Geigy Ag | Codeinsalt of a substituted carbonacid, process of its preparation, its use and pharmaceutical preparations |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6614309A (enExample) * | 1962-06-29 | 1966-12-27 |
-
1971
- 1971-07-14 CA CA118,245A patent/CA964192A/en not_active Expired
- 1971-07-17 DE DE19712135856 patent/DE2135856A1/de active Pending
- 1971-07-20 FR FR7126507A patent/FR2100936A1/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6614309A (enExample) * | 1962-06-29 | 1966-12-27 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0472501A3 (en) * | 1990-08-23 | 1993-02-24 | Ciba-Geigy Ag | Codeinsalt of a substituted carbonacid, process of its preparation, its use and pharmaceutical preparations |
Also Published As
| Publication number | Publication date |
|---|---|
| CA964192A (en) | 1975-03-11 |
| DE2135856A1 (enExample) | 1972-01-27 |
| FR2100936B1 (enExample) | 1974-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |