FR20C1064I1 - - Google Patents

Info

Publication number
FR20C1064I1
FR20C1064I1 FR20C1064C FR20C1064I1 FR 20C1064 I1 FR20C1064 I1 FR 20C1064I1 FR 20C1064 C FR20C1064 C FR 20C1064C FR 20C1064 I1 FR20C1064 I1 FR 20C1064I1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39764856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR20C1064(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of FR20C1064I1 publication Critical patent/FR20C1064I1/fr
Application granted granted Critical
Publication of FR20C1064I2 publication Critical patent/FR20C1064I2/en
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
FR20C1064C 2007-07-20 2020-12-15 SUBSTITUTE INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS Active FR20C1064I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07112881 2007-07-20
EP08785975.7A EP2176231B1 (en) 2007-07-20 2008-07-08 Substituted indazole derivatives active as kinase inhibitors
PCT/EP2008/058861 WO2009013126A1 (en) 2007-07-20 2008-07-08 Substituted indazole derivatives active as kinase inhibitors

Publications (2)

Publication Number Publication Date
FR20C1064I1 true FR20C1064I1 (en) 2021-01-22
FR20C1064I2 FR20C1064I2 (en) 2022-12-02

Family

ID=39764856

Family Applications (1)

Application Number Title Priority Date Filing Date
FR20C1064C Active FR20C1064I2 (en) 2007-07-20 2020-12-15 SUBSTITUTE INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Country Status (28)

Country Link
US (11) US8299057B2 (en)
EP (1) EP2176231B1 (en)
JP (1) JP5506674B2 (en)
KR (2) KR101567763B1 (en)
CN (2) CN101754956B (en)
AR (1) AR067599A1 (en)
AU (1) AU2008280283B2 (en)
BR (1) BRPI0814628B1 (en)
CA (1) CA2693901C (en)
CL (1) CL2008002129A1 (en)
DK (1) DK2176231T3 (en)
EA (1) EA018503B1 (en)
ES (1) ES2605230T3 (en)
FR (1) FR20C1064I2 (en)
HK (2) HK1141278A1 (en)
HU (2) HUE030929T2 (en)
IL (1) IL203292A (en)
NL (1) NL301090I2 (en)
NO (1) NO2020042I1 (en)
NZ (1) NZ583450A (en)
PL (1) PL2176231T3 (en)
PT (1) PT2176231T (en)
SG (1) SG183049A1 (en)
SI (1) SI2176231T1 (en)
TW (1) TWI421073B (en)
UA (1) UA99141C2 (en)
WO (1) WO2009013126A1 (en)
ZA (1) ZA201001086B (en)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2176231T3 (en) 2007-07-20 2017-04-28 Nerviano Medical Sciences S.R.L. Substituted indazole derivatives active as kinase inhibitors
JP5544296B2 (en) * 2007-11-16 2014-07-09 ライジェル ファーマシューティカルズ, インコーポレイテッド Carboxamide, sulfonamide, and amine compounds for metabolic disorders
EP2350075B1 (en) 2008-09-22 2014-03-05 Array Biopharma, Inc. Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
PT2350071E (en) 2008-10-22 2014-04-11 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
US20120121515A1 (en) 2009-03-13 2012-05-17 Lenny Dang Methods and compositions for cell-proliferation-related disorders
AU2010234526B2 (en) 2009-04-06 2016-07-21 Agios Pharmaceuticals, Inc. Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use
KR101351120B1 (en) 2009-06-10 2014-01-15 추가이 세이야쿠 가부시키가이샤 Tetracyclic compound
EP2448581B1 (en) 2009-06-29 2016-12-07 Agios Pharmaceuticals, Inc. Therapeutic compositions and related methods of use
TWI691493B (en) 2009-06-29 2020-04-21 美商阿吉歐斯製藥公司 Therapeutic compounds and compositions
AR077468A1 (en) 2009-07-09 2011-08-31 Array Biopharma Inc PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
EP2491145B1 (en) 2009-10-21 2016-03-09 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
CA2793836C (en) 2009-10-21 2020-03-24 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
ES2642109T3 (en) * 2009-12-09 2017-11-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds for use in the treatment of cancer characterized by having an IDH mutation
WO2011113512A1 (en) * 2010-03-16 2011-09-22 Merck Patent Gmbh Morpholinylquinazolines
BR122019024201B1 (en) 2010-05-20 2021-08-03 Array Biopharma Inc MACROCYCLIC COMPOUND AS TRK KINASE INHIBITORS, ITS USE, AND PHARMACEUTICAL COMPOSITION
TWI476188B (en) 2010-05-27 2015-03-11 Ube Industries Novel indazole derivative or salt thereof and production intermediate thereof, and antioxidant using same
WO2012018668A1 (en) * 2010-08-05 2012-02-09 Amgen Inc. Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase
MX355836B (en) 2010-08-20 2018-05-02 Chugai Pharmaceutical Co Ltd Composition containing tetracyclic compound.
EP2651898B1 (en) 2010-12-17 2015-12-09 Agios Pharmaceuticals, Inc. Novel n-(4-(azetidine-1-carbonyl)phenyl)-(hetero-)arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators
EP2655350B1 (en) 2010-12-21 2016-03-09 Agios Pharmaceuticals, Inc. Bicyclic pkm2 activators
TWI549947B (en) 2010-12-29 2016-09-21 阿吉歐斯製藥公司 Therapeutic compounds and compositions
FR2970967B1 (en) 2011-01-27 2013-02-15 Pf Medicament AZAINDAZOLE OR DIAZAINDAZOLE DERIVATIVES AS A MEDICINAL PRODUCT
ME03074B (en) 2011-05-03 2019-01-20 Agios Pharmaceuticals Inc Pyruvate kinase activators for use in therapy
MX342509B (en) * 2011-05-12 2016-10-03 Nerviano Medical Sciences Srl Substituted indazole derivatives active as kinase inhibitors.
CN102827073A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Therapeutically active compositions and application methods thereof
CN102827170A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Active treatment compositions and use method thereof
US9056867B2 (en) 2011-09-16 2015-06-16 Novartis Ag N-substituted heterocyclyl carboxamides
CN104114543B (en) 2012-01-06 2019-03-15 安吉奥斯医药品有限公司 Therapeutical active compound and its application method
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
CN104395308B (en) 2012-05-23 2016-08-24 内尔维阿诺医学科学有限公司 The preparation method of N-[5-(3,5-diiluoro-benzyl)-1H-indazole-3-base]-4-(4-thyl-piperazin-1-base)-2-(ttetrahydro-pyran-4-base amino)-Benzoylamide
EP2689778A1 (en) 2012-07-27 2014-01-29 Pierre Fabre Medicament Derivatives of azaindoles or diazaindoles for treating pain
EP2689779A1 (en) 2012-07-27 2014-01-29 Pierre Fabre Medicament Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing trk
AU2013321235B2 (en) 2012-09-25 2017-07-20 Chugai Seiyaku Kabushiki Kaisha RET inhibitor
EP2906212A4 (en) 2012-10-15 2016-06-08 Agios Pharmaceuticals Inc Therapeutic compounds and compositions
US8969343B2 (en) * 2012-12-19 2015-03-03 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
CA2917671A1 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. 2,4-or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2015003355A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
JP6441323B2 (en) * 2013-09-25 2018-12-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung Compounds and mesogenic media
TWI672141B (en) * 2014-02-20 2019-09-21 美商醫科泰生技 Molecules for administration to ros1 mutant cancer cells
AU2015229214B2 (en) 2014-03-14 2019-07-11 Les Laboratoires Servier Pharmaceutical compositions of therapeutically active compounds
WO2015143652A1 (en) 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
KR102478887B1 (en) 2014-04-25 2022-12-16 추가이 세이야쿠 가부시키가이샤 Preparation containing tetracyclic compound at high dose
RU2016146119A (en) 2014-04-25 2018-05-29 Чугаи Сейяку Кабусики Кайся NEW CRYSTAL OF TETRACYCLIC COMPOUND
KR101731624B1 (en) * 2014-07-01 2017-05-04 광주과학기술원 Compositions for inducing a cell re-programming
TWI803187B (en) 2014-08-08 2023-05-21 日商中外製藥股份有限公司 Solid dispersion containing amorphous body of tetracyclic compound and preparation
NZ731909A (en) 2014-11-16 2023-11-24 Array Biopharma Inc Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
JP6744309B2 (en) 2014-12-02 2020-08-19 イグニタ,インコーポレイテッド Combination for the treatment of neuroblastoma
US20170356918A1 (en) * 2014-12-03 2017-12-14 Ignyta, Inc. Multiplexed immunohistochemistry assays for diagnosis and treatment of cancer
US10336707B2 (en) 2014-12-16 2019-07-02 Eudendron S.R.L. Heterocyclic derivatives modulating activity of certain protein kinases
JP6741596B2 (en) 2015-01-16 2020-08-19 中外製薬株式会社 Concomitant medication
EP3303382A4 (en) * 2015-05-29 2018-12-19 Ignyta, Inc. Compositions and methods for treating patients with rtk mutant cells
KR20180021745A (en) 2015-06-01 2018-03-05 록쏘 온콜로지, 인코포레이티드 How to diagnose and treat cancer
EP4344703A1 (en) 2015-06-11 2024-04-03 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators
AU2016291676B2 (en) 2015-07-16 2020-04-30 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
EP3362065B1 (en) 2015-10-15 2024-04-03 Les Laboratoires Servier Combination therapy comprising ivosidenib, cytarabine and daunorubicin or idarubicin for treating acute myelogenous leukemia
PT3362066T (en) 2015-10-15 2021-11-16 Celgene Corp Combination therapy for treating malignancies
CA3003153A1 (en) 2015-10-26 2017-05-04 Loxo Oncology, Inc. Point mutations in trk inhibitor-resistant cancer and methods relating to the same
MX2018007266A (en) 2015-12-18 2018-11-09 Ignyta Inc Combinations for the treatment of cancer.
CR20180501A (en) 2016-04-04 2019-04-05 Loxo Oncology Inc Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
SG11201808676RA (en) 2016-04-04 2018-11-29 Loxo Oncology Inc Methods of treating pediatric cancers
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
PT3458456T (en) 2016-05-18 2020-12-07 Array Biopharma Inc Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide
AU2017271458B2 (en) 2016-05-24 2020-11-26 Nerviano Medical Sciences S.R.L. New crystalline form of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
TWI704148B (en) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
JOP20190077A1 (en) 2016-10-10 2019-04-09 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
JOP20190092A1 (en) 2016-10-26 2019-04-25 Array Biopharma Inc PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
US11168090B2 (en) 2017-01-18 2021-11-09 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors
WO2019001379A1 (en) * 2017-06-26 2019-01-03 深圳市塔吉瑞生物医药有限公司 Indazole compound for use in inhibiting kinase activity, composition and application thereof
AU2018302170B2 (en) * 2017-07-19 2024-02-29 Ignyta, Inc. Pharmaceutical compositions comprising entrectinib
US10180422B1 (en) 2017-08-22 2019-01-15 Scripps Health Methods of treating a neuroendocrine tumor
TWI812649B (en) 2017-10-10 2023-08-21 美商絡速藥業公司 Formulations of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
TWI791053B (en) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 Crystalline forms of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile and pharmaceutical composition thereof
JP7311498B2 (en) * 2017-10-17 2023-07-19 イグナイタ インコーポレイテッド Pharmaceutical compositions and dosage forms
KR102179406B1 (en) 2017-10-17 2020-11-16 한국화학연구원 Novel indazole derivatives, and use thereof
CA3080157A1 (en) 2017-10-26 2019-05-02 Array Biopharma Inc. Formulations of a macrocyclic trk kinase inhibitor
KR20200090771A (en) 2017-11-17 2020-07-29 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 Cancer treatment through double MEK signal transduction
CN111630054B (en) 2018-01-18 2023-05-09 奥瑞生物药品公司 Substituted pyrazolo [3,4-d ] pyrimidine compounds as RET kinase inhibitors
US11603374B2 (en) 2018-01-18 2023-03-14 Array Biopharma Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CA3087972C (en) 2018-01-18 2023-01-10 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
WO2019191659A1 (en) 2018-03-29 2019-10-03 Loxo Oncology, Inc. Treatment of trk-associated cancers
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
KR102545594B1 (en) 2018-07-31 2023-06-21 록쏘 온콜로지, 인코포레이티드 (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl Spray-dried dispersions and formulations of )-1H-pyrazole-4-carboxamide
WO2020050241A1 (en) 2018-09-04 2020-03-12 中外製薬株式会社 Method of producing tetracyclic compound
JP2022500383A (en) 2018-09-10 2022-01-04 アレイ バイオファーマ インコーポレイテッド Condensed heterocyclic compound as a RET kinase inhibitor
CN111205227A (en) * 2018-11-22 2020-05-29 四川大学 3-vinyl indazole derivative and preparation method and application thereof
WO2020131674A1 (en) 2018-12-19 2020-06-25 Array Biopharma Inc. 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer
CN113490666A (en) 2018-12-19 2021-10-08 奥瑞生物药品公司 Substituted pyrazolo [1,5-A ] pyridine compounds as inhibitors of FGFR tyrosine kinases
JPWO2020130125A1 (en) 2018-12-21 2021-11-04 第一三共株式会社 Combination of antibody-drug conjugate and kinase inhibitor
EP3725777A1 (en) * 2019-04-17 2020-10-21 Rottapharm Biotech S.r.l. Benzo- and pyrido-pyrazoles as protein kinase inhibitors
EP4003309A1 (en) 2019-07-31 2022-06-01 F. Hoffmann-La Roche AG New pharmaceutical formulation
TW202114676A (en) 2019-08-14 2021-04-16 瑞士商F 賀夫曼 賀許公司 Methods of treating cancer
WO2021084260A1 (en) 2019-11-01 2021-05-06 Johnson Matthey Public Limited Company Crystalline entrectinib anhydrate and monohydrate forms; crystalline entrectinib thf, nitromethane, isopropyl acetate and methanol solvate forms; processes for preparing a crystalline entrectinib anhydrate form
CN111171009B (en) * 2020-01-10 2022-07-12 安礼特(上海)医药科技有限公司 Entrictinib crystal form and preparation method thereof
WO2021197467A1 (en) * 2020-04-02 2021-10-07 上海华汇拓医药科技有限公司 Multi-target anti-tumor compound, preparation method therefor and use thereof
CN113801062B (en) * 2020-06-15 2023-05-26 沈阳药科大学 Preparation method of 3-amino-5- (3, 5-difluorobenzyl) -1H-indazole
EP4182310A1 (en) * 2020-07-15 2023-05-24 IFM Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN114230518A (en) * 2021-12-13 2022-03-25 海南梵圣生物科技有限公司 Preparation method of 5-benzyl-1H-indazole-3-amine compound
US20230250060A1 (en) * 2022-01-12 2023-08-10 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
WO2023205701A1 (en) 2022-04-20 2023-10-26 Kumquat Biosciences Inc. Macrocyclic heterocycles and uses thereof
CN115746023A (en) * 2022-10-27 2023-03-07 复旦大学 Indazole structure-containing heterocyclic macrocyclic compound as protein kinase inhibitor and preparation method thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002353186A1 (en) * 2001-12-19 2003-06-30 Smithkline Beecham P.L.C. (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors
FR2836915B1 (en) * 2002-03-11 2008-01-11 Aventis Pharma Sa AMINOINDAZOLE DERIVATIVES, PREPARATION METHOD AND INTERMEDIATES THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
FR2871158A1 (en) 2004-06-04 2005-12-09 Aventis Pharma Sa SUBSTITUTED INDAZOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE
AU2007336335B8 (en) * 2006-12-20 2014-07-24 Nerviano Medical Sciences S.R.L. Indazole derivatives as kinase inhibitors for the treatment of cancer
PL2176231T3 (en) 2007-07-20 2017-04-28 Nerviano Medical Sciences S.R.L. Substituted indazole derivatives active as kinase inhibitors
WO2010069966A1 (en) * 2008-12-18 2010-06-24 Nerviano Medical Sciences S.R.L. Substituted indazole derivatives active as kinase inhibitors
CN104395308B (en) * 2012-05-23 2016-08-24 内尔维阿诺医学科学有限公司 The preparation method of N-[5-(3,5-diiluoro-benzyl)-1H-indazole-3-base]-4-(4-thyl-piperazin-1-base)-2-(ttetrahydro-pyran-4-base amino)-Benzoylamide
WO2015059746A1 (en) * 2013-10-21 2015-04-30 トヨタ自動車株式会社 Cell system

Also Published As

Publication number Publication date
NL301090I2 (en) 2021-06-17
CN103923072B (en) 2017-05-31
KR101636312B1 (en) 2016-07-05
BRPI0814628B1 (en) 2022-04-05
CN101754956B (en) 2014-04-23
US20100292207A1 (en) 2010-11-18
US9255087B2 (en) 2016-02-09
US20160095856A1 (en) 2016-04-07
US20150057291A1 (en) 2015-02-26
US9029356B2 (en) 2015-05-12
JP5506674B2 (en) 2014-05-28
US9102662B2 (en) 2015-08-11
AU2008280283B2 (en) 2013-11-07
CL2008002129A1 (en) 2008-11-21
EA201070167A1 (en) 2013-07-30
US8299057B2 (en) 2012-10-30
CN103923072A (en) 2014-07-16
NO2020042I1 (en) 2020-11-24
EA018503B1 (en) 2013-08-30
US9616059B2 (en) 2017-04-11
ES2605230T3 (en) 2017-03-13
EP2176231B1 (en) 2016-10-19
US20150057292A1 (en) 2015-02-26
FR20C1064I2 (en) 2022-12-02
NL301090I1 (en) 2021-02-03
US9085558B2 (en) 2015-07-21
EP2176231A1 (en) 2010-04-21
SG183049A1 (en) 2012-08-30
HK1141278A1 (en) 2010-11-05
AR067599A1 (en) 2009-10-14
HUE030929T2 (en) 2017-06-28
US8673893B2 (en) 2014-03-18
US10081622B2 (en) 2018-09-25
DK2176231T3 (en) 2016-12-12
HK1200162A1 (en) 2015-07-31
WO2009013126A1 (en) 2009-01-29
US20130018036A1 (en) 2013-01-17
SI2176231T1 (en) 2017-01-31
ZA201001086B (en) 2011-04-28
PT2176231T (en) 2016-12-09
US20190241546A1 (en) 2019-08-08
NZ583450A (en) 2012-05-25
CA2693901A1 (en) 2009-01-29
BRPI0814628A2 (en) 2017-07-04
AU2008280283A1 (en) 2009-01-29
KR101567763B1 (en) 2015-11-12
TW200911233A (en) 2009-03-16
US20170158677A1 (en) 2017-06-08
US20200377487A1 (en) 2020-12-03
KR20100044859A (en) 2010-04-30
US20220144813A1 (en) 2022-05-12
UA99141C2 (en) 2012-07-25
IL203292A (en) 2016-06-30
KR20150058568A (en) 2015-05-28
CN101754956A (en) 2010-06-23
US20150065520A1 (en) 2015-03-05
AU2008280283A2 (en) 2010-03-18
CA2693901C (en) 2015-12-29
US20140228351A1 (en) 2014-08-14
JP2011502959A (en) 2011-01-27
PL2176231T3 (en) 2017-04-28
HUS2000049I1 (en) 2021-01-28
TWI421073B (en) 2014-01-01

Similar Documents

Publication Publication Date Title
FR20C1064I1 (en)
CN300830605S (zh) 后窗盖
CN300732228S (zh) 包装袋(膏药)
CN300727292S (zh) 摆件(唐·昭陵六骏)
CN300727317S (zh) 汽车(ga6463e3)
CN300727512S (zh) 移动插座(kl05-08)
CN300727580S (zh) 音箱
CN300755426S (zh) 领带(“一摁得”122)
CN300728916S (zh) 桌子(nb890)
CN300728861S (zh) 椅座(la-825)
CN300729279S (zh) 气动扳手(89700一英寸)
CN300729293S (zh) 保险箱手轮
CN300731595S (zh) 妆台(爱尔兰tw-809)
CN300915279S (zh) 剪刀(sh025.06)
CN300733447S (zh) 水龙头(ta34141)
CN300885923S (zh) 沙发(c232)
CN300734296S (zh) 拉杆箱(1)
CN300729878S (zh) 金属轮毂(462)
CN300730731S (zh) 手电筒(tf-b)
CN300730840S (zh) 蜡烛(117)
CN300852410S (zh) 手提袋(3)
CN300805870S (zh) 垫子(53)
CN300731279S (zh) 面料(艺术染整2007-16)
CN300840996S (zh) 包装袋(07010)
CN300728317S (zh) 扣板(07-07)