FR2086133A2 - N-bis (3-thienylpropyl) phenethylamines -with coronary vasodilator - activity - Google Patents

N-bis (3-thienylpropyl) phenethylamines -with coronary vasodilator - activity

Info

Publication number
FR2086133A2
FR2086133A2 FR7103246A FR7103246A FR2086133A2 FR 2086133 A2 FR2086133 A2 FR 2086133A2 FR 7103246 A FR7103246 A FR 7103246A FR 7103246 A FR7103246 A FR 7103246A FR 2086133 A2 FR2086133 A2 FR 2086133A2
Authority
FR
France
Prior art keywords
alkyl
thienylpropyl
phenethylamines
bis
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7103246A
Other languages
French (fr)
Other versions
FR2086133B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT5307270A external-priority patent/IT1051557B/en
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Publication of FR2086133A2 publication Critical patent/FR2086133A2/en
Application granted granted Critical
Publication of FR2086133B2 publication Critical patent/FR2086133B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. are of formula: their isomers and acid-addn. salts (X = thienyl opt. substd. with one or more alkyls; A . B = C(OH)CH2 or C=CH- in which one of the H atoms of B or the CH2 gp. between B and -NR1 may be replaced by alkyl; R1 = H, alkyl; R2 = H, alkyl; R3 = H, OH; R4, R5 = H, OH, halogen, alkyl, haloalkyl, alkoxy). The alkyl substition of the B and CH2 gps. are an addn. to the parent patent.
FR7103246A 1970-04-17 1971-02-01 N-bis (3-thienylpropyl) phenethylamines -with coronary vasodilator - activity Granted FR2086133A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2965670A 1970-04-17 1970-04-17
IT5307270A IT1051557B (en) 1970-08-27 1970-08-27 1,1-dithienyl (3)-propane derivs - for treatment of heart and circula diseases

Publications (2)

Publication Number Publication Date
FR2086133A2 true FR2086133A2 (en) 1971-12-31
FR2086133B2 FR2086133B2 (en) 1974-08-30

Family

ID=26329528

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7103246A Granted FR2086133A2 (en) 1970-04-17 1971-02-01 N-bis (3-thienylpropyl) phenethylamines -with coronary vasodilator - activity

Country Status (2)

Country Link
FR (1) FR2086133A2 (en)
SE (1) SE394280B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377396A1 (en) * 1977-01-12 1978-08-11 Degussa DITHIENYLALKYLAMINES, THEIR PREPARATION AND THEIR THERAPEUTIC USES

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7004410A (en) * 1969-04-26 1970-10-28

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7004410A (en) * 1969-04-26 1970-10-28

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377396A1 (en) * 1977-01-12 1978-08-11 Degussa DITHIENYLALKYLAMINES, THEIR PREPARATION AND THEIR THERAPEUTIC USES

Also Published As

Publication number Publication date
SE394280B (en) 1977-06-20
FR2086133B2 (en) 1974-08-30

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