FR2081559A1 - 1-(p-chlorophenyl)-4-(3-aroylamino-butyl)-piperazines - useful as anti-histamines and spasmolytics - Google Patents
1-(p-chlorophenyl)-4-(3-aroylamino-butyl)-piperazines - useful as anti-histamines and spasmolyticsInfo
- Publication number
- FR2081559A1 FR2081559A1 FR7007536A FR7007536A FR2081559A1 FR 2081559 A1 FR2081559 A1 FR 2081559A1 FR 7007536 A FR7007536 A FR 7007536A FR 7007536 A FR7007536 A FR 7007536A FR 2081559 A1 FR2081559 A1 FR 2081559A1
- Authority
- FR
- France
- Prior art keywords
- chlorophenyl
- spasmolytics
- histamines
- useful
- aroylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001387 anti-histamine Effects 0.000 title abstract 2
- 229940125715 antihistaminic agent Drugs 0.000 title abstract 2
- 239000000739 antihistaminic agent Substances 0.000 title abstract 2
- 230000002048 spasmolytic effect Effects 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- BGJSXRVXTHVRSN-UHFFFAOYSA-N 1,3,5-trioxane Chemical group C1OCOCO1 BGJSXRVXTHVRSN-UHFFFAOYSA-N 0.000 abstract 1
- -1 3-aminobutyl compound Chemical class 0.000 abstract 1
- ROKUZUIBUDMHLY-UHFFFAOYSA-N 4-[4-(4-chlorophenyl)piperazin-1-yl]butan-2-one Chemical compound C1CN(CCC(=O)C)CCN1C1=CC=C(Cl)C=C1 ROKUZUIBUDMHLY-UHFFFAOYSA-N 0.000 abstract 1
- 206010048768 Dermatosis Diseases 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 229910017912 NH2OH Inorganic materials 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 208000028004 allergic respiratory disease Diseases 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- UNEIHNMKASENIG-UHFFFAOYSA-N para-chlorophenylpiperazine Chemical compound C1=CC(Cl)=CC=C1N1CCNCC1 UNEIHNMKASENIG-UHFFFAOYSA-N 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7007536A FR2081559A1 (en) | 1970-03-03 | 1970-03-03 | 1-(p-chlorophenyl)-4-(3-aroylamino-butyl)-piperazines - useful as anti-histamines and spasmolytics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7007536A FR2081559A1 (en) | 1970-03-03 | 1970-03-03 | 1-(p-chlorophenyl)-4-(3-aroylamino-butyl)-piperazines - useful as anti-histamines and spasmolytics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2081559A1 true FR2081559A1 (en) | 1971-12-10 |
| FR2081559B1 FR2081559B1 (enExample) | 1973-04-06 |
Family
ID=9051566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7007536A Granted FR2081559A1 (en) | 1970-03-03 | 1970-03-03 | 1-(p-chlorophenyl)-4-(3-aroylamino-butyl)-piperazines - useful as anti-histamines and spasmolytics |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2081559A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997010229A1 (en) * | 1995-09-13 | 1997-03-20 | Neurogen Corporation | Novel n-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1193052B (de) * | 1958-08-01 | 1965-05-20 | Miles Lab | Verfahren zur Herstellung von 4-Phenyl-piperazino-alkylderivaten |
-
1970
- 1970-03-03 FR FR7007536A patent/FR2081559A1/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1193052B (de) * | 1958-08-01 | 1965-05-20 | Miles Lab | Verfahren zur Herstellung von 4-Phenyl-piperazino-alkylderivaten |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997010229A1 (en) * | 1995-09-13 | 1997-03-20 | Neurogen Corporation | Novel n-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands |
| US5932734A (en) * | 1995-09-13 | 1999-08-03 | Neurogen Corporation | N-aminoalkylfluorenecarboxamides |
| US6015900A (en) * | 1995-09-13 | 2000-01-18 | Neurogen Corporation | N-aminoalkylfluorenecarboxamides |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2081559B1 (enExample) | 1973-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |