FR2073277A1 - 1-phenoxy alkyl-4-hydroxy alkyl piperazine - anti-inflammatories and analgesics - Google Patents
1-phenoxy alkyl-4-hydroxy alkyl piperazine - anti-inflammatories and analgesicsInfo
- Publication number
- FR2073277A1 FR2073277A1 FR6943647A FR6943647A FR2073277A1 FR 2073277 A1 FR2073277 A1 FR 2073277A1 FR 6943647 A FR6943647 A FR 6943647A FR 6943647 A FR6943647 A FR 6943647A FR 2073277 A1 FR2073277 A1 FR 2073277A1
- Authority
- FR
- France
- Prior art keywords
- aryl
- alkyl
- piperazine
- inflammatories
- analgesics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
- 229940035676 analgesics Drugs 0.000 title abstract 2
- 239000000730 antalgic agent Substances 0.000 title abstract 2
- 230000001760 anti-analgesic effect Effects 0.000 title abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- -1 hydroxyalkyl piperazine Chemical compound 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- YYFLBDSMQRWARK-UHFFFAOYSA-N 1-(2-bromoethoxy)-4-chlorobenzene Chemical compound ClC1=CC=C(OCCBr)C=C1 YYFLBDSMQRWARK-UHFFFAOYSA-N 0.000 abstract 1
- WFCSWCVEJLETKA-UHFFFAOYSA-N 2-piperazin-1-ylethanol Chemical compound OCCN1CCNCC1 WFCSWCVEJLETKA-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 229940125716 antipyretic agent Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004617 chromonyl group Chemical group O1C(=CC(C2=CC=CC=C12)=O)* 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000003106 haloaryl group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 235000015320 potassium carbonate Nutrition 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR6943647A FR2073277A1 (en) | 1969-12-17 | 1969-12-17 | 1-phenoxy alkyl-4-hydroxy alkyl piperazine - anti-inflammatories and analgesics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR6943647A FR2073277A1 (en) | 1969-12-17 | 1969-12-17 | 1-phenoxy alkyl-4-hydroxy alkyl piperazine - anti-inflammatories and analgesics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2073277A1 true FR2073277A1 (en) | 1971-10-01 |
| FR2073277B1 FR2073277B1 (enExample) | 1973-01-12 |
Family
ID=9044698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR6943647A Granted FR2073277A1 (en) | 1969-12-17 | 1969-12-17 | 1-phenoxy alkyl-4-hydroxy alkyl piperazine - anti-inflammatories and analgesics |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2073277A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2621082A1 (de) * | 1975-05-13 | 1976-11-25 | Andre Buzas | Piperazinderivat, verfahren zu seiner herstellung und seine verwendung als arzneimittel |
| EP1988902A4 (en) * | 2006-02-15 | 2009-05-06 | Ms Science Corp | PIPERAZIN DERIVATIVES |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3342822A (en) * | 1966-06-09 | 1967-09-19 | Mcneilab Inc | 1, 4-bis(p-cyano(and nitro)-phenoxy-ethyl)-piperazines |
-
1969
- 1969-12-17 FR FR6943647A patent/FR2073277A1/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3342822A (en) * | 1966-06-09 | 1967-09-19 | Mcneilab Inc | 1, 4-bis(p-cyano(and nitro)-phenoxy-ethyl)-piperazines |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2621082A1 (de) * | 1975-05-13 | 1976-11-25 | Andre Buzas | Piperazinderivat, verfahren zu seiner herstellung und seine verwendung als arzneimittel |
| EP1988902A4 (en) * | 2006-02-15 | 2009-05-06 | Ms Science Corp | PIPERAZIN DERIVATIVES |
| JP2009526844A (ja) * | 2006-02-15 | 2009-07-23 | 株式会社エムズサイエンス | ピペラジン誘導体 |
| US20090221607A1 (en) * | 2006-02-15 | 2009-09-03 | M's Science Corporation | Piperazine Derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2073277B1 (enExample) | 1973-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |