FR2070102A1 - 1 subst phenyl 2 amino ethanols useful as beta - adrenergic agents peripheral vasodilators and hypo- - Google Patents

1 subst phenyl 2 amino ethanols useful as beta - adrenergic agents peripheral vasodilators and hypo-

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Publication number
FR2070102A1
FR2070102A1 FR7035552A FR7035552A FR2070102A1 FR 2070102 A1 FR2070102 A1 FR 2070102A1 FR 7035552 A FR7035552 A FR 7035552A FR 7035552 A FR7035552 A FR 7035552A FR 2070102 A1 FR2070102 A1 FR 2070102A1
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FR
France
Prior art keywords
alkyl
subst
phenyl
useful
straight
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Granted
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FR7035552A
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French (fr)
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FR2070102B1 (en
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Continental Pharma Inc
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Continental Pharma Inc
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Publication of FR2070102A1 publication Critical patent/FR2070102A1/en
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Granted legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

1-Subst-phenyl-2-amino-ethanols useful as beta adrenergic agents peripheral vasodilators and hypotensive agents M3A. Are new compounds of formula (I):- R7-CHOH.CHR4NR5R6 (I) where R7= and R1=RS, RSO, RSO2, RO, RSe or RSeO2, R=H, straight or branched chain alkyl (pref. 1-8C), alkenyl, alkynyl or acetyl; R2 and R3 are same or different alkyl, halogen, NH2, NO2, COOH, COO Alkyl, alkyl NH, acyl NH or CF3, one of R2 and R3 may be H and R2 and R3 may also be alkoxy or alkylthio in so far as this group is different from R1; R4=H or straight or branched chain alkyl (pref. 1-4C), R5 and R6 are same or different H, straight or branched chain opt. substd. alkyl, cycloalkyl, alkenyl, alkynyl, piperidino, pyridino, or pyrimidino or R5 and R6 together with the adjacent N atom may form an opt. substd. heterocyclic ring), including their salts. They are prepared by (a) reduction of R7COCHR7NR8R6; (b) REACTION OF R7-Z where Z is -CH -CH -R4 or CHOHCHR7x (where X is halogen) with R5R6NH; (c) by reductive amination of R7COCOR4; (d) by alkylin or reductive alkyln of R7CHOH-CHR4.NH2 and (e) by reductive alkyln. of R7COC(R4)=NOH.
FR7035552A 1969-10-01 1970-10-01 1 subst phenyl 2 amino ethanols useful as beta - adrenergic agents peripheral vasodilators and hypo- Granted FR2070102A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE79767 1969-10-01
BE93537 1970-09-03

Publications (2)

Publication Number Publication Date
FR2070102A1 true FR2070102A1 (en) 1971-09-10
FR2070102B1 FR2070102B1 (en) 1974-08-23

Family

ID=25647478

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7035552A Granted FR2070102A1 (en) 1969-10-01 1970-10-01 1 subst phenyl 2 amino ethanols useful as beta - adrenergic agents peripheral vasodilators and hypo-

Country Status (17)

Country Link
JP (1) JPS541693B1 (en)
AR (1) AR194457A1 (en)
AT (1) AT323135B (en)
CA (1) CA953723A (en)
CH (1) CH542177A (en)
CS (1) CS191158B2 (en)
DK (1) DK147853C (en)
FI (1) FI52714C (en)
FR (1) FR2070102A1 (en)
HU (1) HU167354B (en)
IE (1) IE34545B1 (en)
NL (1) NL156688B (en)
NO (1) NO132865C (en)
OA (1) OA03659A (en)
SE (1) SE384855B (en)
SU (1) SU578860A3 (en)
YU (1) YU35580B (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183681A1 (en) * 1972-03-20 1973-12-21 Smith Kline French Lab
FR2416012A1 (en) * 1978-02-01 1979-08-31 Wellcome Found DERIVATIVES OF IMIDAZOLE AND MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES
FR2471374A1 (en) * 1979-12-07 1981-06-19 Cosmos Enterprise NOVEL PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYPHENYL) -2- (4-BENZYLPIPERIDINO) -PROPANOL AND ITS ACID ADDITION SALTS
FR2503705A1 (en) * 1981-04-14 1982-10-15 Synthelabo PHENETHANOLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP0069012A1 (en) * 1981-06-29 1983-01-05 Societe De Recherches Industrielles S.O.R.I. Benzoyl-phenyl-piperidine derivatives, their preparation and medicinal use
FR2534580A1 (en) * 1982-10-13 1984-04-20 Synthelabo PHENYL-1 PIPERIDINO-2 PROPANOL DERIVATIVES, THEIR PREPARATION, AND MEDICINES THAT CONTAIN THEM
FR2537132A1 (en) * 1982-12-06 1984-06-08 Lafon Labor New sulphur-containing 2-amino-1-phenyl-1-ethanol derivatives, their therapeutic use and process for preparing them
WO1992013834A1 (en) * 1991-02-04 1992-08-20 Zeneca Limited Preparation of trisubstituted benzoic acids and intermediates
WO1997017324A1 (en) * 1995-11-10 1997-05-15 Rhodia Chimie Aromatic thioether acylation method
WO1998025903A1 (en) * 1996-12-13 1998-06-18 Sanofi 1-phenylalkyl-1,2,3,6-tetrahydropyridines for treating alzheimer's disease

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201714734D0 (en) * 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) * 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1503517A (en) * 1965-04-22 1967-12-01 Bayer Ag Manufacturing process of d - (-) - n-alkyl-1-phenyl-2-aminoethanols

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1503517A (en) * 1965-04-22 1967-12-01 Bayer Ag Manufacturing process of d - (-) - n-alkyl-1-phenyl-2-aminoethanols

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183681A1 (en) * 1972-03-20 1973-12-21 Smith Kline French Lab
FR2416012A1 (en) * 1978-02-01 1979-08-31 Wellcome Found DERIVATIVES OF IMIDAZOLE AND MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES
FR2471374A1 (en) * 1979-12-07 1981-06-19 Cosmos Enterprise NOVEL PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYPHENYL) -2- (4-BENZYLPIPERIDINO) -PROPANOL AND ITS ACID ADDITION SALTS
FR2503705A1 (en) * 1981-04-14 1982-10-15 Synthelabo PHENETHANOLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP0063084A1 (en) * 1981-04-14 1982-10-20 Synthelabo Phenethanol amine derivatives, their preparation and use in medicine
US4528294A (en) * 1981-06-29 1985-07-09 Societe De Recherches Industrielle S.O.R.I. Benzoyl-phenyl-piperidine derivatives
EP0069012A1 (en) * 1981-06-29 1983-01-05 Societe De Recherches Industrielles S.O.R.I. Benzoyl-phenyl-piperidine derivatives, their preparation and medicinal use
FR2534580A1 (en) * 1982-10-13 1984-04-20 Synthelabo PHENYL-1 PIPERIDINO-2 PROPANOL DERIVATIVES, THEIR PREPARATION, AND MEDICINES THAT CONTAIN THEM
EP0109317A3 (en) * 1982-10-13 1984-08-08 Synthelabo Phenyl-1-piperidino-2-propanol derivatives, their preparation and medicaments containing them
FR2537132A1 (en) * 1982-12-06 1984-06-08 Lafon Labor New sulphur-containing 2-amino-1-phenyl-1-ethanol derivatives, their therapeutic use and process for preparing them
WO1992013834A1 (en) * 1991-02-04 1992-08-20 Zeneca Limited Preparation of trisubstituted benzoic acids and intermediates
WO1997017324A1 (en) * 1995-11-10 1997-05-15 Rhodia Chimie Aromatic thioether acylation method
FR2741067A1 (en) * 1995-11-10 1997-05-16 Rhone Poulenc Chimie PROCESS FOR ACYLATION OF AN AROMATIC THIOETHER
WO1998025903A1 (en) * 1996-12-13 1998-06-18 Sanofi 1-phenylalkyl-1,2,3,6-tetrahydropyridines for treating alzheimer's disease
FR2757160A1 (en) * 1996-12-13 1998-06-19 Sanofi Sa 1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES

Also Published As

Publication number Publication date
YU35580B (en) 1981-04-30
NL156688B (en) 1978-05-16
SU578860A3 (en) 1977-10-30
CS191158B2 (en) 1979-06-29
CH542177A (en) 1973-09-30
IE34545B1 (en) 1975-06-11
NL7014444A (en) 1971-04-05
FR2070102B1 (en) 1974-08-23
DK147853C (en) 1986-05-20
SE384855B (en) 1976-05-24
DK147853B (en) 1984-12-24
AT323135B (en) 1975-06-25
OA03659A (en) 1971-12-24
IE34545L (en) 1971-04-01
NO132865C (en) 1976-01-21
AR194457A1 (en) 1973-07-23
CA953723A (en) 1974-08-27
HU167354B (en) 1975-09-27
FI52714C (en) 1977-11-10
NO132865B (en) 1975-10-13
JPS541693B1 (en) 1979-01-27
YU238570A (en) 1980-09-25
FI52714B (en) 1977-08-01

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