FR2068405A1 - Synergistic acetanilide type/benzoic ester type local anaesthetics - Google Patents
Synergistic acetanilide type/benzoic ester type local anaestheticsInfo
- Publication number
- FR2068405A1 FR2068405A1 FR6935364A FR6935364A FR2068405A1 FR 2068405 A1 FR2068405 A1 FR 2068405A1 FR 6935364 A FR6935364 A FR 6935364A FR 6935364 A FR6935364 A FR 6935364A FR 2068405 A1 FR2068405 A1 FR 2068405A1
- Authority
- FR
- France
- Prior art keywords
- soln
- type
- synergistic
- acetanilide
- local anaesthetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FZERHIULMFGESH-UHFFFAOYSA-N N-phenylacetamide Chemical compound CC(=O)NC1=CC=CC=C1 FZERHIULMFGESH-UHFFFAOYSA-N 0.000 title 2
- 229960001413 acetanilide Drugs 0.000 title 1
- -1 benzoic ester Chemical class 0.000 title 1
- 229960005015 local anesthetics Drugs 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 abstract 2
- 230000003444 anaesthetic effect Effects 0.000 abstract 2
- 229960004194 lidocaine Drugs 0.000 abstract 2
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 abstract 2
- GHSCYMOJHVOGDJ-UHFFFAOYSA-N 2-(diethylamino)ethyl 4-amino-2-hydroxybenzoate Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1O GHSCYMOJHVOGDJ-UHFFFAOYSA-N 0.000 abstract 1
- HQFWVSGBVLEQGA-UHFFFAOYSA-N 4-aminobenzoic acid 3-(dibutylamino)propyl ester Chemical compound CCCCN(CCCC)CCCOC(=O)C1=CC=C(N)C=C1 HQFWVSGBVLEQGA-UHFFFAOYSA-N 0.000 abstract 1
- LIWOWASNSWUKPF-UHFFFAOYSA-N Tolycaine hydrochloride Chemical compound Cl.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C(=O)OC LIWOWASNSWUKPF-UHFFFAOYSA-N 0.000 abstract 1
- 229940124326 anaesthetic agent Drugs 0.000 abstract 1
- 229960003369 butacaine Drugs 0.000 abstract 1
- 229960001290 butanilicaine Drugs 0.000 abstract 1
- VWYQKFLLGRBICZ-UHFFFAOYSA-N butanilicaine Chemical compound CCCCNCC(=O)NC1=C(C)C=CC=C1Cl VWYQKFLLGRBICZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940105270 carbocaine Drugs 0.000 abstract 1
- 210000003074 dental pulp Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 229960002372 tetracaine Drugs 0.000 abstract 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The anaesthetics mixture comprises equal parts of (i) an aqs. soln. of 13-17% of lignocaine, carbocaine, scandicaine, hostacaine, or baycaine; (ii) an aqs. soln. of 8-12% of tetracaine, butacaine, oxyprocaine, millicaine, urnacaine, or poimacaine; and (iii) an aqs. soln. contg. 1-4% of between 80. (RTM). The anaesthetic is instilled directly into dental pulp, and is also used in ear, nose and throat treatment. The prefd. composn. contains equal parts of a 15% soln. of lignocaine, a 12% soln. of tetraaine and a 1.5% soln. of Tween 80.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR6935364A FR2068405A1 (en) | 1969-10-15 | 1969-10-15 | Synergistic acetanilide type/benzoic ester type local anaesthetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR6935364A FR2068405A1 (en) | 1969-10-15 | 1969-10-15 | Synergistic acetanilide type/benzoic ester type local anaesthetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2068405A1 true FR2068405A1 (en) | 1971-08-27 |
| FR2068405B1 FR2068405B1 (en) | 1973-01-12 |
Family
ID=9041585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR6935364A Granted FR2068405A1 (en) | 1969-10-15 | 1969-10-15 | Synergistic acetanilide type/benzoic ester type local anaesthetics |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2068405A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0415413A1 (en) * | 1989-08-31 | 1991-03-06 | Warner-Lambert Company | Acat inhibitors |
| US5522726A (en) * | 1994-10-27 | 1996-06-04 | Hodosh; Milton | Method for anesthetizing teeth |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3172805A (en) * | 1962-07-12 | 1965-03-09 | Colgate Palmolive Co | Anesthetic preparations containing potentiated 4[3-(p-butoxyphenoxy)-propyl morpholine; 3-butyl-1-(2-dimetylamino ethoxy) isoquinoline; 2-dimethylamino-2' 6'-acetoxylidide |
-
1969
- 1969-10-15 FR FR6935364A patent/FR2068405A1/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3172805A (en) * | 1962-07-12 | 1965-03-09 | Colgate Palmolive Co | Anesthetic preparations containing potentiated 4[3-(p-butoxyphenoxy)-propyl morpholine; 3-butyl-1-(2-dimetylamino ethoxy) isoquinoline; 2-dimethylamino-2' 6'-acetoxylidide |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0415413A1 (en) * | 1989-08-31 | 1991-03-06 | Warner-Lambert Company | Acat inhibitors |
| US5522726A (en) * | 1994-10-27 | 1996-06-04 | Hodosh; Milton | Method for anesthetizing teeth |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2068405B1 (en) | 1973-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |